Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline

Autor: Sergei Boichuk, Firyuza Bikinieva, Elena Valeeva, Pavel Dunaev, Maria Vasileva, Pavel Kopnin, Ekaterina Mikheeva, Tatyana Ivoilova, Ilshat Mustafin, Aigul Galembikova

Publikováno v: Diagnostics, Vol 13, Iss 16, p 2646 (2023)

Aim: To establish a p53-negative osteosarcoma (OS) SaOS-2 cellular subline exhibiting resistance to specific chemotherapeutic agents, including topoisomerase II inhibitors, taxanes, and vinca alkaloids. Methods: The OS subline exhibiting resistance t

Externí odkaz: https://doaj.org/article/de40a3537f9c47499e69fb4ae8f2a9d0

Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo

Autor: Sergei Boichuk, Aigul Galembikova, Pavel Dunaev, Ekaterina Micheeva, Elena Valeeva, Maria Novikova, Natalya Khromova, Pavel Kopnin

Publikováno v: Molecules, Vol 23, Iss 10, p 2643 (2018)

Dysregulation of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling pathway is frequently observed in multiple human malignancies, and thus, therapeutic strategies targeting FGFs and FGFRs in human cancer are being

Externí odkaz: https://doaj.org/article/57fcc37f994348e583c28a8cad12385e

ASSOCIATIONS OF POLYMORPHISM OF THE VITAMIN D RECEPTOR (VDR) GENE AND GINGIVAL RECESSION IN MIXED DENTITION

Autor: Aigul Akisheva, Ildaria Valeeva, Elena Mamaeva, Alsu Akhtereeva, Elena Valeeva, Ildus Akhmetov

Publikováno v: Actual problems in dentistry. 18:90-96

Subject of study. The development of new approaches to early diagnosis and identification of predisposition to the formation of gingival recession in children is an urgent task of modern dentistry. It is known that vitamin D plays an important role,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a959d910989c0142f83339f0efc5ec6
https://doi.org/10.18481/2077-7566-2022-18-4-90-96

Dopamine receptors genes activity under chronic stress in rats

Autor: R.D. Mukhametshina, Elena Valeeva, A.D. Mukhametshina, A.G. Mukhamedzhanova, O.A. Kravtsova, D.O. Nikitin, I. I. Semina, I.Kh. Valeeva

Publikováno v: Biomics. 13:1-7

Stress response is a multifactorial condition which is formed under extreme environmental exposure due to various neuroendocrine systems interactions. Dopaminergic system plays a key role in stress response through the dopamine which effect is realiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f03bc4ef482d2023b0e30d90ba7dd73d
https://doi.org/10.31301/2221-6197.bmcs.2021-1

Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair

Autor: Ilmira Nurgatina, Pavel Dunaev, Firuza Bikinieva, Sergei Boichuk, Aida Aukhadieva, Elena Valeeva, A R Galembikova, Alexey Sabirov

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8842, p 8842 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 21; Issue 22; Pages: 8842

Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and progression. Accumulating evidence has also implicated AKT as a potent modulator of anti-can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e833d18928ee1f6c4477c6823b664b77
https://pubmed.ncbi.nlm.nih.gov/33266502