Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Elena V. Rudakova"'
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Yu Astakhova, Elena N. Timokhina, Olga G. Serebryakova, Alexander V. Shchepochkin, Maxim A. Averkov, Irina A. Utepova, Nadezhda S. Demina, Eugene V. Radchenko, Vladimir A. Palyulin, Vladimir P. Fisenko, Sergey O. Bachurin, Oleg N. Chupakhin, Valery N. Charushin, Rudy J. Richardson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES). We also studied the abilities of the new co
Externí odkaz:
https://doaj.org/article/19995bc7cc79494d8334518aebc4070e
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Y. Astakhova, Elena N. Timokhina, Igor V. Serkov, Alexey N. Proshin, Yuliya V. Soldatova, Darya A. Poletaeva, Irina I. Faingold, Viktoriya A. Mumyatova, Alexey A. Terentiev, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 29, Iss 2, p 321 (2024)
Effective therapeutics for Alzheimer’s disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hyd
Externí odkaz:
https://doaj.org/article/9dc8029bd61a4fcb9dc34956137feaf5
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Maria V. Grishchenko, Sofya V. Lushchekina, Tatiana Y. Astakhova, Olga G. Serebryakova, Elena N. Timokhina, Ekaterina F. Zhilina, Evgeny V. Shchegolkov, Mariya V. Ulitko, Eugene V. Radchenko, Vladimir A. Palyulin, Yanina V. Burgart, Victor I. Saloutin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2285 (2023)
A series of previously synthesized conjugates of tacrine and salicylamide was extended by varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize salicylimine derivatives. The hybrids exhibited broad-spectrum bio
Externí odkaz:
https://doaj.org/article/7e0b27a3aeb244eeb22116b3b545edc1
Autor:
Yanina V. Burgart, Natalia A. Elkina, Evgeny V. Shchegolkov, Olga P. Krasnykh, Galina F. Makhaeva, Galina A. Triandafilova, Sergey Yu. Solodnikov, Natalia P. Boltneva, Elena V. Rudakova, Nadezhda V. Kovaleva, Olga G. Serebryakova, Mariya V. Ulitko, Sophia S. Borisevich, Natalia A. Gerasimova, Natalia P. Evstigneeva, Sergey A. Kozlov, Yuliya V. Korolkova, Artem S. Minin, Anna V. Belousova, Evgenii S. Mozhaitsev, Artem M. Klabukov, Victor I. Saloutin
Publikováno v:
Molecules, Vol 28, Iss 1, p 59 (2022)
4-Arylhydrazinylidene-5-(polyfluoroalkyl)pyrazol-3-ones (4-AHPs) were found to be obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3-oxoesters with hydrazines, by the azo coupling of 4-nonsubstituted pyrazol-5-ol
Externí odkaz:
https://doaj.org/article/e03f60e649344091824c96142959378b
Autor:
Sergey O. Bachurin, Elena F. Shevtsova, Galina F. Makhaeva, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Elena V. Rudakova, Darya V. Vinogradova, Pavel N. Shevtsov, Elena A. Pushkareva, Ludmila G. Dubova, Tatiana P. Serkova, Ivan M. Veselov, Vladimir P. Fisenko, Rudy J. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13925 (2022)
The development of multi-target-directed ligands (MTDLs) would provide effective therapy of neurodegenerative diseases (ND) with complex and nonclear pathogenesis. A promising method to create such potential drugs is combining neuroactive pharmacopho
Externí odkaz:
https://doaj.org/article/bed9b9696c514d1caf241d2b10e8865d
Autor:
Yanina V. Burgart, Galina F. Makhaeva, Olga P. Krasnykh, Sophia S. Borisevich, Natalia A. Agafonova, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Evgeny V. Shchegolkov, Galina A. Triandafilova, Denis A. Gazizov, Olga G. Serebryakova, Maria V. Ulitko, Sergey L. Khursan, Victor I. Saloutin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 22, p 7722 (2022)
One of the powerful antioxidants used clinically is Edaravone (EDA). We synthesized a series of new EDA analogs, 4-aminopyrazol-5-ol hydrochlorides, including polyfluoroalkyl derivatives, via the reduction of 4-hydroxyiminopyrazol-5-ones. The primary
Externí odkaz:
https://doaj.org/article/3cd9c6dde8a64d83a9b45ad8db1476b6
Autor:
Natalia A. Elkina, Maria V. Grishchenko, Evgeny V. Shchegolkov, Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Y. Astakhova, Eugene V. Radchenko, Vladimir A. Palyulin, Ekaterina F. Zhilina, Anastasiya N. Perminova, Luka S. Lapshin, Yanina V. Burgart, Victor I. Saloutin, Rudy J. Richardson
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1551 (2022)
Alzheimer’s disease (AD) is considered a modern epidemic because of its increasing prevalence worldwide and serious medico-social consequences, including the economic burden of treatment and patient care. The development of new effective therapeuti
Externí odkaz:
https://doaj.org/article/407988391fe84cfd910efe4df0c33cf1
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 3, p 1060 (2022)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-
Externí odkaz:
https://doaj.org/article/90ae90fd4e9f4057a738309e4978db2b
Autor:
Sergey O. Bachurin, Galina F. Makhaeva, Elena F. Shevtsova, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Pavel N. Shevtsov, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Elena A. Pushkareva, Natalia P. Boltneva, Sofya V. Lushchekina, Alexey V. Gabrelyan, Vladimir L. Zamoyski, Lyudmila G. Dubova, Elena V. Rudakova, Vladimir P. Fisenko, Elena V. Bovina, Rudy J. Richardson
Publikováno v:
Molecules, Vol 26, Iss 18, p 5527 (2021)
A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized. Conjugates act simultaneously on several biological str
Externí odkaz:
https://doaj.org/article/b4963a08afd643abb60d9c73f498c6f7
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 25, Iss 24, p 5891 (2020)
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s
Externí odkaz:
https://doaj.org/article/6ea0a7ce84b54558a5b89fe5c4b00ea2