Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Elena V. Olshevskaya"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Retinal membrane guanylyl cyclase (RetGC), regulated by guanylyl cyclase activating proteins (GCAPs) via negative calcium-feedback, is one of the most critically important enzymes in vertebrate rod and cone physiology, enabling their sensitivity to l
Externí odkaz:
https://doaj.org/article/402a69cc8a804204891b27ece2fd3e17
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 5 (2012)
Guanylyl cyclase activating proteins (GCAP)1 are calcium/magnesium binding proteins within neuronal calcium sensor proteins group (NCS) of the EF-hand proteins superfamily. GCAPs activate retinal guanylyl cyclase (RetGC) in vertebrate photoreceptors
Externí odkaz:
https://doaj.org/article/403994875e3345669362809e02f6986d
Publikováno v:
The Journal of Biological Chemistry
Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging from rod dysfunction to rod and cone degeneration. We tested how the mutations causing recess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a49c69180482e40f35eb1c12fd181ff
https://doi.org/10.1074/jbc.ra120.015553
https://doi.org/10.1074/jbc.ra120.015553
Publikováno v:
The Journal of Biological Chemistry
Different forms of photoreceptor degeneration cause blindness. Retinal degeneration-3 protein (RD3) deficiency in photoreceptors leads to recessive congenital blindness. We proposed that aberrant activation of the retinal membrane guanylyl cyclase (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777ae28d6c427ff826d869780f9a510f
http://europepmc.org/articles/PMC8517212
http://europepmc.org/articles/PMC8517212
Publikováno v:
Journal of Biological Chemistry. 294:13729-13739
Deficiency of RD3 (retinal degeneration 3) protein causes recessive blindness and photoreceptor degeneration in humans and in the rd3 mouse strain, but the disease mechanism is unclear. Here, we present evidence that RD3 protects photoreceptors from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b79244757c1475a3e655301f86159ec
https://doi.org/10.1074/jbc.ra119.009948
https://doi.org/10.1074/jbc.ra119.009948
Publikováno v:
The Journal of Biological Chemistry
Retinal degeneration-3 protein (RD3) deficiency causes photoreceptor dysfunction and rapid degeneration in the rd3 mouse strain and in human Leber's congenital amaurosis, a congenital retinal dystrophy that results in early vision loss. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a12b46a5f551647f8fe3f46372d4e6
https://pubmed.ncbi.nlm.nih.gov/33539922
https://pubmed.ncbi.nlm.nih.gov/33539922
Autor:
Shinya Sato, Elena V. Olshevskaya, Alexander M. Dizhoor, Vladimir J. Kefalov, Igor V. Peshenko
Publikováno v:
The Journal of Neuroscience. 38:2990-3000
The Arg838Ser mutation in retinal membrane guanylyl cyclase 1 (RetGC1) has been linked to autosomal dominant cone–rod dystrophy type 6 (CORD6). It is believed that photoreceptor degeneration is caused by the altered sensitivity of RetGC1 to calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf9323958039ce4a8f171a387f0a10d
https://doi.org/10.1523/jneurosci.2985-17.2018
https://doi.org/10.1523/jneurosci.2985-17.2018
Autor:
Samuel G. Jacobson, Seher Abbas, Alexander M. Dizhoor, Elena V. Olshevskaya, Artur V. Cideciyan, Alexander Scholten, Alexander Sumaroka, Igor V. Peshenko, Karl-Wilhelm Koch
The guanylyl cyclase-activating protein, GCAP1, activates photoreceptor membrane guanylyl cyclase (RetGC) in the light, when free Ca(2+) concentrations decline, and decelerates the cyclase in the dark, when Ca(2+) concentrations rise. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bbb5106754ebf588b800018040ecdd
https://europepmc.org/articles/PMC6416442/
https://europepmc.org/articles/PMC6416442/
Publikováno v:
Journal of Biological Chemistry. 291:19713-19723
Retinal degeneration 3 (RD3) protein, essential for normal expression of retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC catalytic activity and stimulation by guanylyl cyclase-activating proteins (GCAPs). In a mouse ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d941a1353e5165afba568b964b311e1b
https://doi.org/10.1074/jbc.m116.742288
https://doi.org/10.1074/jbc.m116.742288
Autor:
Qing Ruan, K. Tyler McCullough, Elena V. Olshevskaya, Seok Hong Min, Shreyasi Choudhury, William W. Hauswirth, Jim Peterson, Xi-Qin Ding, Shannon E. Boye, Igor V. Peshenko, Zhonghong Zhang, Sanford L. Boye, Alexander M. Dizhoor
Publikováno v:
Human Gene Therapy. 26:575-592
Mutations in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). GUCY2D encodes retinal guanylate cyclase-1 (retGC1), a protein expressed exclusively in outer segments of photoreceptors and essential for timely recovery from photoexcita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e130f05208c300138eae60e5f727f5b7
https://doi.org/10.1089/hum.2015.053
https://doi.org/10.1089/hum.2015.053