Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Elena V. Kudryashova"'
Publikováno v:
Biophysica, Vol 4, Iss 3, Pp 340-356 (2024)
Herein, we propose an analytical approach based on intermolecular fluorescent resonant energy transfer (FRET) pairs for the visualization of specific enzyme activity in model biomembranes and in living cells. Cell visualizations with fluorescent conf
Externí odkaz:
https://doaj.org/article/98d09e16cee84d878a1f02b8ad59e50b
Publikováno v:
Polysaccharides, Vol 4, Iss 4, Pp 343-357 (2023)
The aim of this work was to investigate the physico-chemical and biological properties of cyclodextrin-based polymers by the example of interaction with human serum albumin, erythrocytes, and bacteria to understand the prospects of their application
Externí odkaz:
https://doaj.org/article/97b94d53b75041a2b4c0cd7f9b71fb68
Publikováno v:
Chemistry, Vol 5, Iss 3, Pp 1942-1960 (2023)
Here, we propose a drug delivery system for ciprofloxacin (CF) based on cyclodextrin (CD) polymer. We obtained a 3D matrix system with encapsulated drug molecules by crosslinking CF+CD non-covalent complexes with 1.6-hexamethylene isocyanate. The obt
Externí odkaz:
https://doaj.org/article/bf8815b220244b44a4b08d67b385fe36
Publikováno v:
Gels, Vol 10, Iss 9, p 567 (2024)
Rhodamine 6G (R6G) and 4-nitro-2,1,3-benzoxadiazole (NBD) linked through a spacer molecule spermidine (spd), R6G-spd-NBD, produces a fluorescent probe with pH-sensitive FRET (Förster (fluorescence) resonance energy transfer) effect that can be usefu
Externí odkaz:
https://doaj.org/article/f359d958e6354409a11d19b365db4410
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1007 (2024)
Cancer cells are known to create an acidic microenvironment (the Warburg effect). At the same time, fluorescent dyes can be sensitive to pH, showing a sharp increase or decrease in fluorescence depending on pH. However, modern applications, such as c
Externí odkaz:
https://doaj.org/article/be4e0af2a6764a35b46086111359d14a
Publikováno v:
Polymers, Vol 16, Iss 15, p 2132 (2024)
L-asparaginases (ASP) and Doxorubicin (Dox) are both used in the treatment of leukemia, including in combination. We have attempted to investigate if their combination within the same targeted delivery vehicle can make such therapy more efficacious.
Externí odkaz:
https://doaj.org/article/0136b1e8622e4219ab56440477dd3abd
Autor:
Natalia V. Dobryakova, Maria V. Dumina, Alexander A. Zhgun, Marina V. Pokrovskaya, Svetlana S. Aleksandrova, Dmitry D. Zhdanov, Elena V. Kudryashova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4174 (2024)
This study investigated the effect of polycationic and uncharged polymers (and oligomers) on the catalytic parameters and thermostability of L-asparaginase from Thermococcus sibiricus (TsA). This enzyme has potential applications in the food industry
Externí odkaz:
https://doaj.org/article/65b28ca77a0947c4856f2b5c26a3d8e2
Publikováno v:
Polymers, Vol 16, Iss 6, p 739 (2024)
Förster resonance energy transfer (FRET) probes are a promising tool for studying numerous biochemical processes. In this paper, we show the application of the FRET phenomenon to observe the micelle formation from surfactants, micelles self-assembli
Externí odkaz:
https://doaj.org/article/98fa2e87535e4db898f2d824dabebe3a
Autor:
Irina M. Le-Deygen, Anastasia S. Safronova, Polina V. Mamaeva, Ilya M. Kolmogorov, Anna A. Skuredina, Elena V. Kudryashova
Publikováno v:
Biophysica, Vol 2, Iss 4, Pp 353-365 (2022)
We have investigated the nature of the interaction of small organic drug molecules with lipid membranes of various compositions. Using infrared spectroscopy and differential scanning calorimetry methods, we studied the role of the structure of the ac
Externí odkaz:
https://doaj.org/article/92eabb9b2c9d48719868f085240bbd15
Autor:
Irina M. Le-Deygen, Viktoria V. Rokosovina, Anna A. Skuredina, Ivan D. Yakimov, Elena V. Kudryashova
Publikováno v:
Future Pharmacology, Vol 2, Iss 3, Pp 330-346 (2022)
Liposomal complexes with mucoadhesive polymers, e.g., mannosylated chitosan, are considered as prospective antituberculosis drug delivery systems. The properties of such complexes can be critically affected by the charge and phase state of liposomes.
Externí odkaz:
https://doaj.org/article/0f8e5c8f0ee04719aa0440655a3904b4