Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elena V. Grigor'eva"'
Autor:
Elena V. Grigor’eva, Lana V. Karapetyan, Anastasia A. Malakhova, Sergey P. Medvedev, Julia M. Minina, Varduhi H. Hayrapetyan, Valentina S. Vardanyan, Suren M. Zakian, Arsen Arakelyan, Roksana Zakharyan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6102 (2024)
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein. Despite the existing data on MEFV muta
Externí odkaz:
https://doaj.org/article/eb271f669bc4489d83c6cf63cf08053d
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Denis A. Tarasevich, Sophia V. Pavlova, Kamila R. Valetdinova, Julia M. Minina, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 744 (2024)
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative diseases, in particular Parkinson’s disease (PD). Since there is curren
Externí odkaz:
https://doaj.org/article/40ac1f132b0c46d1bfe312659914ee7f
Autor:
Elena V. Grigor’eva, Anastasia A. Malakhova, Lilit Ghukasyan, Varduhi Hayrapetyan, Sofi Atshemyan, Valentina Vardanyan, Suren M. Zakian, Roksana Zakharyan, Arsen Arakelyan
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103147- (2023)
The study of pathological processes in cells carrying mutations should be carried out in comparison with a healthy control group. Familial Mediterranean fever (FMF), which is caused by a mutation in the MEFV gene, is predominantly found in people of
Externí odkaz:
https://doaj.org/article/caca0b4698b54c53bf36c3d4e0f1fe3b
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Sophia V. Pavlova, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 327 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder that ranks second in prevalence after Alzheimer’s disease. The number of PD diagnoses increases annually. Nevertheless, modern PD treatments merely mitigate symptoms rather than preventing
Externí odkaz:
https://doaj.org/article/4e47ad45cc044c648b1e5408ea4481b5
Autor:
Tatiana A. Shnaider, Anna A. Khabarova, Ksenia N. Morozova, Anastasia M. Yunusova, Sophia A. Yakovleva, Anastasia S. Chvileva, Ekaterina R. Wolf, Elena V. Kiseleva, Elena V. Grigor’eva, Viktori Y. Voinova, Maria A. Lagarkova, Ekaterina A. Pomerantseva, Elizaveta V. Musatova, Alexander V. Smirnov, Anna V. Smirnova, Diana S. Stoklitskaya, Tatiana I. Arefieva, Daria A. Larina, Tatiana V. Nikitina, Inna E. Pristyazhnyuk
Publikováno v:
Cells, Vol 12, Iss 23, p 2702 (2023)
Cohen syndrome is an autosomal recessive disorder caused by VPS13B (COH1) gene mutations. This syndrome is significantly underdiagnosed and is characterized by intellectual disability, microcephaly, autistic symptoms, hypotension, myopia, retinal dys
Externí odkaz:
https://doaj.org/article/46fae80a53d840f5ae947d70a2822115
Autor:
Elena V. Grigor'eva, Anastasia A. Malakhova, Diana A. Sorogina, Sofia V. Pavlova, Tuyana B. Malankhanova, Natalia Yu. Abramycheva, Sergey A. Klyushnikov, Sergey N. Illarioshkin, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102868- (2022)
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (HTT) protein. In HD, dysregulation of multiple cellular processes occurs, resulting in the death o
Externí odkaz:
https://doaj.org/article/9857262fec844cbd82b18c42cd467eba
Autor:
Alena E. Kopytova, George N. Rychkov, Alexander A. Cheblokov, Elena V. Grigor’eva, Mikhail A. Nikolaev, Elena S. Yarkova, Diana A. Sorogina, Farid M. Ibatullin, Galina V. Baydakova, Artem D. Izyumchenko, Daria A. Bogdanova, Vitali M. Boitsov, Akim V. Rybakov, Irina V. Miliukhina, Vadim A. Bezrukikh, Galina N. Salogub, Ekaterina Y. Zakharova, Sofya N. Pchelina, Anton K. Emelyanov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9105 (2023)
Mutations in the GBA1 gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), cause Gaucher disease (GD) and are the most common genetic risk factor for Parkinson’s disease (PD). Pharmacological chaperones (PCs) are being developed as an al
Externí odkaz:
https://doaj.org/article/a540faae94864a4a873d0bc05f379f47
Autor:
Elena V. Grigor’eva, Alena E. Kopytova, Elena S. Yarkova, Sophia V. Pavlova, Diana A. Sorogina, Anastasia A. Malakhova, Tuyana B. Malankhanova, Galina V. Baydakova, Ekaterina Y. Zakharova, Sergey P. Medvedev, Sofia N. Pchelina, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4437 (2023)
GBA variants increase the risk of Parkinson’s disease (PD) by 10 times. The GBA gene encodes the lysosomal enzyme glucocerebrosidase (GCase). The p.N370S substitution causes a violation of the enzyme conformation, which affects its stability in the
Externí odkaz:
https://doaj.org/article/365091594fc848809889675d20533582
Autor:
Elena V. Grigor'eva, Elena S. Drozdova, Diana A. Sorogina, Anastasia A. Malakhova, Sofia V. Pavlova, Yuri V. Vyatkin, Elena A. Khabarova, Jamil A. Rzaev, Sergey P. Medvedev, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102651- (2022)
Mutation in the glucocerebrosidase encoding gene (GBA) is one of the most frequent genetic cause of Parkinson's disease. ICGi034-A induced pluripotent stem cell (iPSC) line obtained by reprogramming peripheral blood mononuclear cells (PBMCs) of a pat
Externí odkaz:
https://doaj.org/article/6e4280cca5bb42a1b8c025ab96ee1e67
Autor:
Ksenia N Morozova, Lyubov A Suldina, Tuyana B Malankhanova, Elena V Grigor'eva, Suren M Zakian, Elena Kiseleva, Anastasia A Malakhova
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204735 (2018)
Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern geno
Externí odkaz:
https://doaj.org/article/17ccde2e1369434f962ba49b85febfec