Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Elena V Bichenkova"'
Autor:
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. mi
Externí odkaz:
https://doaj.org/article/f4b56814e4af47f7b059a8be3d18d8f9
Autor:
Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova
Publikováno v:
Nucleic Acids Research
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many copies of eme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7b808fe6bedc0a0aab05633989d108
https://pubmed.ncbi.nlm.nih.gov/34967410
https://pubmed.ncbi.nlm.nih.gov/34967410
Autor:
Valentin V. Vlassov, Elena V. Bichenkova, Marina A. Zenkova, Bahareh Amirloo, S. K. Miroshnichenko, O. A. Patutina
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:803-812
Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis. miRNases integrate in their structure an addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a4018b1ca54c61682c8b8bdcf4f71fc
https://doi.org/10.1134/s1068162019060281
https://doi.org/10.1134/s1068162019060281
Autor:
Marina A. Zenkova, David Clarke, Tom Brown, Bahareh Amirloo, Kepa K. Burusco, Alexander A. Lomzov, Aled Williams, Elena V. Bichenkova, Yaroslav Staroseletz
Publikováno v:
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco, K, Clarke, D J, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates ', Nucleic acids research, vol. 48, no. 19, pp. 10662-10679 . https://doi.org/10.1093/nar/gkaa780
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3370e00e689f01039fccc16fa1d0b0f
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
Autor:
Antonina A. Fedorova, M. B. Gebrezgiabher, Waleed Abdelhalim Yousef Zalloum, Elena V. Bichenkova, Steven M. Miles, Marina A. Zenkova, David Clarke
Publikováno v:
Gebrezgiabher, M, Zalloum, W A Y, Clarke, D, Miles, S, Fedorova, A A, Zenkova, M & Bichenkova, E 2020, ' RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases : behavior of recognition and cleavage elements under physiological conditions ', Journal of Biomolecular Structure and Dynamics . https://doi.org/10.1080/07391102.2020.1751711
Sequence-specific protein-based ribonucleases are not found in nature. Absolute sequence selectivity in RNA cleavage in vivo normally requires multi-component complexes that recruit a guide RNA or DNA for target recognition and a protein–RNA assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c667e5842de77ee011ed9120119186db
https://pubmed.ncbi.nlm.nih.gov/32248755
https://pubmed.ncbi.nlm.nih.gov/32248755
Autor:
Natalia G. Beloglazova, Martin M. Fabani, Nikolai N. Polushin, Vladimir V. Sil'nikov, Valentin V. Vlassov, Elena V. Bichenkova, Marina A. Zenkova
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Design of site-selective artificial ribonucleases (aRNases) is one of the most challenging tasks in RNA targeting. Here, we designed and studied oligonucleotide-based aRNases containing multiple imidazole residues in the catalytic part and systematic
Externí odkaz:
https://doaj.org/article/38411f498deb447aa2464d2998911c1f
Autor:
N. L. Mironova, Marina A. Zenkova, S. K. Miroshnichenko, Elena V. Bichenkova, Aleksandra V Sen'kova, O. A. Patutina, David Clarke, Valentin V. Vlassov
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Patutina, O A, Miroshnichenko, S K, Mironova, N L, Sen'kova, A V, Bichenkova, E, Clarke, D, Vlassov, V V & Zenkova, M 2019, ' Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model ', Frontiers in Pharmacology . https://doi.org/10.3389/fphar.2019.00879
Frontiers in Pharmacology
Patutina, O A, Miroshnichenko, S K, Mironova, N L, Sen'kova, A V, Bichenkova, E, Clarke, D, Vlassov, V V & Zenkova, M 2019, ' Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model ', Frontiers in Pharmacology . https://doi.org/10.3389/fphar.2019.00879
Frontiers in Pharmacology
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5825b2496cc22b031973d5318e333ff5
https://www.frontiersin.org/article/10.3389/fphar.2019.00879/full
https://www.frontiersin.org/article/10.3389/fphar.2019.00879/full
Autor:
Sameen, Yousaf, Patrick J S, King, Aline F, Miller, Alberto, Saiani, David J, Clarke, Linda T, Trivoluzzi, Harmesh S, Aojula, Elena V, Bichenkova
Publikováno v:
Analytical Chemistry
DNA and RNA biomarkers have not progressed beyond the automated specialized clinic due to failure in the reproducibility necessary to standardize robust and rapid nucleic acid detection at the point of care, where health outcomes can be most improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da58403a229c696185382757aafde6fc
https://pubmed.ncbi.nlm.nih.gov/31246004
https://pubmed.ncbi.nlm.nih.gov/31246004
Autor:
Svetlana Gaponova, O. A. Patutina, Daria Chiglintseva, Thomas Heyman, Yaroslav Staroseletz, Bahareh Amirloo, Elena V. Bichenkova, Marina A. Zenkova
Publikováno v:
Molecules
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded082a5998cbe2cfe9d63e630771df5
https://doi.org/10.3390/molecules26061732
https://doi.org/10.3390/molecules26061732
Autor:
Elena Goncharova, Elena I. Ryabchikova, Elena V. Bichenkova, Marina A. Zenkova, Valentin V. Vlassov, Antonina A. Fedorova, Ekatherina A. Burakova, Lyudmila S. Koroleva, Vladimir N. Silnikov
Publikováno v:
Antiviral Research. 133:73-84
Artificial ribonucleases (aRNases) are small compounds catalysing RNA cleavage. Recently we demonstrated that aRNases readily inactivate various viruses in vitro. Here, for three series of aRNases (1,4-diazabicyclo [2.2.2]octane-based and peptide-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7a1d6392cb8ad739469113a1a295f0
https://doi.org/10.1016/j.antiviral.2016.07.014
https://doi.org/10.1016/j.antiviral.2016.07.014