Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elena Tosoni"'
Autor:
Emanuela Ruggiero, Ilaria Frasson, Elena Tosoni, Matteo Scalabrin, Rosalba Perrone, Maja Marušič, Janez Plavec, Sara N. Richter
Publikováno v:
ACS Infectious Diseases. 8:958-968
HIV-1 integrated long terminal repeat (LTR) promoter activity is modulated by folding of its G-rich region into non-canonical nucleic acids structures, such as G-quadruplexes (G4s), and their interaction with cellular proteins. Here, by a combined pu
Autor:
Susanna Cogo, Franz Y. Ho, Elena Tosoni, James E. Tomkins, Isabella Tessari, Lucia Iannotta, Thomas J. Montine, Claudia Manzoni, Patrick A. Lewis, Luigi Bubacco, Marie-Christine Chartier Harlin, Jean-Marc Taymans, Arjan Kortholt, Jeremy Nichols, Laura Cendron, Laura Civiero, Elisa Greggio
Publikováno v:
Brain Research, 1778:147781. ELSEVIER SCIENCE BV
Leucine-rich repeat kinase 2 (LRRK2) has taken center stage in Parkinson's disease (PD) research as mutations cause familial PD and more common variants increase lifetime risk for disease. One unique feature in LRRK2 is the coexistence of GTPase/Roc
Publikováno v:
Genes, Chromosomes and Cancer. 52:832-844
Common fragile sites are hotspots for chromosome instability and co-localize to cancer genomic rearrangements. Whether these loci may be considered stable in human subjects under physiological conditions remains an open question. Here we show by mole
Autor:
Matteo Nadai, Elena Butovskaya, Matteo Scalabrin, Sara N. Richter, Dan Fabris, Elena Tosoni, Giorgio Palù, Rosalba Perrone, Ilaria Frasson
Publikováno v:
Nucleic Acids Research
Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that control the folding of this region of proviral genome by inducing/stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f496b77d1aad081b7044da565aa8e6b8
http://hdl.handle.net/11577/3168422
http://hdl.handle.net/11577/3168422
Publikováno v:
Genes, chromosomescancer. 52(9)
Common fragile sites are hotspots for chromosome instability and co-localize to cancer genomic rearrangements. Whether these loci may be considered stable in human subjects under physiological conditions remains an open question. Here we show by mole
Mammalian genomes are replicated under a flexible program, with random use of origins and variable fork rates, and many details of the process must be still unraveled. Molecular combing provides a set of direct data regarding the replication profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68d0849b1caa6940a66d0cbb0e09908
http://hdl.handle.net/11577/2684004
http://hdl.handle.net/11577/2684004
The replication dynamics at common fragile site FRA6E has been evaluated by molecular combing and interphase fluorescent in situ hybridisation (FISH) in primary human lymphocytes cultured under normal or aphidicolin-induced stress conditions. FRA6E i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7e6b6147b93d95a8c896017c2fae1d
http://hdl.handle.net/11577/2444188
http://hdl.handle.net/11577/2444188
Autor:
Matteo, Scalabrin, Ilaria, Frasson, Emanuela, Ruggiero, Rosalba, Perrone, Elena, Tosoni, Sara, Lago, Martina, Tassinari, Giorgio, Palù, Sara N, Richter
Publikováno v:
Scientific Reports
G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular epigenetic regulators. A dynamic G-quadruplex forming region in the HIV-1 LTR promoter represses HIV-1 transcription when in the folded conformation. This activity i