Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elena Tomaselli Muensterman"'
Autor:
Richard A Furie, Van Anh Nguyen, Feng Hong, Scott R P McDonnell, Noah M Walton, Carsten Merkwirth, Deborah Berg, Elena Tomaselli Muensterman
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 1 (2024)
Objective To evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic lupus erythematosus (SLE).Methods A phase 1b double-blind, placebo-controlled, multicentre s
Externí odkaz:
https://doaj.org/article/9545ba1275374259ad9a0a70853a795b
Autor:
Todd Walroth, Gabriela Williams, Erika N Titus-Lay, Paul Moe, Carol A Ott, James E. Tisdale, Elena Tomaselli Muensterman, Heather A. Jaynes, Michelle Wilbrandt
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:494-500
Study objective Methadone is associated with QT interval prolongation and torsades de pointes. Expert panel recommendations advocate a pre-methadone electrocardiogram (ECG) and another ECG at 30 days of therapy in patients with risk factors. Some gui
Autor:
Brian R. Overholser, James E. Tisdale, Heather A. Jaynes, Changyu Shen, Elena Tomaselli Muensterman, Kevin M. Sowinski, Richard J. Kovacs
Publikováno v:
Clin Pharmacol Ther
We have previously reported that transdermal testosterone attenuates drug-induced QT interval lengthening in older men. However, it is unknown whether this is due to modulation of early ventricular repolarization, late repolarization, or both. In a s
Autor:
James E. Tisdale, Todd Walroth, Gabriela Williams, Erika N Titus-Lay, Elena Tomaselli Muensterman, Carol A Ott, Paul Moe, Michelle Wilbrandt, Heather A. Jaynes
Publikováno v:
Circulation. 142
Introduction: Methadone, a racemic mixture of S - and R -enantiomers, prolongs the QT interval and causes torsades de pointes. Methadone has been shown to lengthen late ventricular repolarization, represented by the T peak-Tend interval, which is mod
Autor:
James E. Tisdale, Todd Walroth, Gabriela Williams, Zeruesenay Desta, Heather A. Jaynes, Carol A Ott, Erika N Titus-Lay, Michelle Wilbrandt, Paul Moe, Elena Tomaselli Muensterman
Publikováno v:
PharmacotherapyREFERENCES. 41(3)
STUDY OBJECTIVE Methadone is associated with QT interval prolongation and torsades de pointes. The objective of this study was to (a) determine the incidence of QT interval prolongation among patients on maintenance methadone therapy in an urban opio
Autor:
Nan Wang, Vijay U. Rao, Brian R. Overholser, Kevin M. Sowinski, Jo E. Rodgers, Ahmed Aldemerdash, James E. Tisdale, Mark D. Fisch, Richard J. Kovacs, Elena Tomaselli Muensterman, Chia Chi Hsu, Heather A. Jaynes
Publikováno v:
J Card Fail
Background Patients with heart failure (HF) with reduced ejection fraction demonstrate enhanced response to drug-induced QT interval lengthening and are at increased risk for torsades de pointes. The influence of HF with preserved ejection fraction (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297367958e8f94051d0417112cd0085a
https://europepmc.org/articles/PMC7529874/
https://europepmc.org/articles/PMC7529874/
Autor:
Kevin M. Sowinski, Elena Tomaselli Muensterman, Changyu Shen, Brian R. Overholser, Heather A. Jaynes, James E. Tisdale, Richard J. Kovacs
Publikováno v:
Circulation
Publikováno v:
Pharmacotherapy. 38(8)
Prolongation of the heart rate-corrected QT (QTc) interval increases the risk for torsade de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors that include female sex, older age, heart failur
Publikováno v:
Therapeutic Innovation & Regulatory Science. :216847901987406
Background: Because of the increasing demand for drugs addressing life-threatening and rare diseases, regulatory agencies have developed a variety of accelerated regulatory pathways. These programs are aimed at prioritizing the most promising drug ca