Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Elena Sugrue"'
Autor:
Spyros Lytras, Arthur Wickenhagen, Elena Sugrue, Douglas G Stewart, Simon Swingler, Anna Sims, Hollie Jackson Ireland, Emma L Davies, Eliza M Ludlam, Zhuonan Li, Joseph Hughes, Sam J Wilson
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002398 (2023)
The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 20
Externí odkaz:
https://doaj.org/article/044c4448a3ee4d4ab82590b54230a869
Autor:
Elena Sugrue, Arthur Wickenhagen, Nardus Mollentze, Muhamad Afiq Aziz, Vattipally B Sreenu, Sven Truxa, Lily Tong, Ana da Silva Filipe, David L Robertson, Joseph Hughes, Suzannah J Rihn, Sam J Wilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010973 (2022)
HIV-1 transmission via sexual exposure is an inefficient process. When transmission does occur, newly infected individuals are colonized by the descendants of either a single virion or a very small number of establishing virions. These transmitted fo
Externí odkaz:
https://doaj.org/article/312eb46f19e0404c960c54ff41b6efb3
Autor:
Andrew E Shaw, Suzannah J Rihn, Nardus Mollentze, Arthur Wickenhagen, Douglas G Stewart, Richard J Orton, Srikeerthana Kuchi, Siddharth Bakshi, Mila Rodriguez Collados, Matthew L Turnbull, Joseph Busby, Quan Gu, Katherine Smollett, Connor G G Bamford, Elena Sugrue, Paul C D Johnson, Ana Filipe Da Silva, Alfredo Castello, Daniel G Streicker, David L Robertson, Massimo Palmarini, Sam J Wilson
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Externí odkaz:
https://doaj.org/article/93c6a324bb0649b4bf2748908f349e90
Autor:
Suzannah J Rihn, Andres Merits, Siddharth Bakshi, Matthew L Turnbull, Arthur Wickenhagen, Akira J T Alexander, Carla Baillie, Benjamin Brennan, Fiona Brown, Kirstyn Brunker, Steven R Bryden, Kerry A Burness, Stephen Carmichael, Sarah J Cole, Vanessa M Cowton, Paul Davies, Chris Davis, Giuditta De Lorenzo, Claire L Donald, Mark Dorward, James I Dunlop, Matthew Elliott, Mazigh Fares, Ana da Silva Filipe, Joseph R Freitas, Wilhelm Furnon, Rommel J Gestuveo, Anna Geyer, Daniel Giesel, Daniel M Goldfarb, Nicola Goodman, Rory Gunson, C James Hastie, Vanessa Herder, Joseph Hughes, Clare Johnson, Natasha Johnson, Alain Kohl, Karen Kerr, Hannah Leech, Laura Sandra Lello, Kathy Li, Gauthier Lieber, Xiang Liu, Rajendra Lingala, Colin Loney, Daniel Mair, Marion J McElwee, Steven McFarlane, Jenna Nichols, Kyriaki Nomikou, Anne Orr, Richard J Orton, Massimo Palmarini, Yasmin A Parr, Rute Maria Pinto, Samantha Raggett, Elaine Reid, David L Robertson, Jamie Royle, Natalia Cameron-Ruiz, James G Shepherd, Katherine Smollett, Douglas G Stewart, Meredith Stewart, Elena Sugrue, Agnieszka M Szemiel, Aislynn Taggart, Emma C Thomson, Lily Tong, Leah S Torrie, Rachel Toth, Margus Varjak, Sainan Wang, Stuart G Wilkinson, Paul G Wyatt, Eva Zusinaite, Dario R Alessi, Arvind H Patel, Ali Zaid, Sam J Wilson, Suresh Mahalingam
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001091 (2021)
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In
Externí odkaz:
https://doaj.org/article/cc007f107e3a422ab1bfef32714d1945
Autor:
Stuart Ruddell, Elena Sugrue, Sarah Memarzadeh, Lorna Mae Hellam, Sam J. Wilson, David J. France
Publikováno v:
Molecules, Vol 26, Iss 13, p 3919 (2021)
PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack of information regarding the optical purity (enantiomeric excess) of the single stereogenic centre of PF74 has resu
Externí odkaz:
https://doaj.org/article/666eda4f3c904ec18c1d5317683ce75d
Autor:
Tatheer Naqvi, Andrew C Warden, Nigel French, Elena Sugrue, Paul D Carr, Colin J Jackson, Colin Scott
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94177 (2014)
Phosphotriesterases (PTEs) have been isolated from a range of bacterial species, including Agrobcaterium radiobacter (PTEAr), and are efficient enzymes with broad substrate ranges. The turnover rate of PTEAr for the common organophosphorous insectici
Externí odkaz:
https://doaj.org/article/9368485664c641d6bef0e4fa39e28c2d
Autor:
Tong Zhu, Renwick C. J. Dobson, David M Wood, David Coombes, Katherine A. Donovan, Elena Sugrue
Publikováno v:
European Biophysics Journal. 49:761-772
Pyruvate kinase catalyses the final step of the glycolytic pathway in central energy metabolism. The monomeric structure comprises three domains: a catalytic TIM-barrel, a regulatory domain involved in allosteric activation, and a lid domain that enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0980681f09707252368461a7b7215276
https://doi.org/10.1007/s00249-020-01466-5
https://doi.org/10.1007/s00249-020-01466-5
Autor:
Elena Sugrue, Arthur Wickenhagen, Nardus Mollentze, Muhamad Afiq Aziz, Vattipally B Sreenu, Sven Truxa, Lily Tong, Ana da Silva Filipe, David L Robertson, Joseph Hughes, Suzannah J Rihn, Sam J Wilson
HIV-1 transmission via sexual exposure is a relatively inefficient process. When successful transmission does occur, newly infected individuals are colonized by either a single or a very small number of establishing virion(s). These transmitted found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f85691cd3d21b9da4cf33bbc6dc964
https://doi.org/10.1101/2021.12.18.473292
https://doi.org/10.1101/2021.12.18.473292
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469a676bb0e1666248dc84b8e1cb1c58
http://europepmc.org/articles/PMC8423302
http://europepmc.org/articles/PMC8423302
Autor:
Fabio T. M. Costa, Paul J. Lehner, Sam J. Wilson, Suzannah J. Rihn, David Robertson, Srikeerthana Kuchi, Quan Gu, Thomas W M Crozier, Alfredo Castello-Palomares, Rute Maria Pinto, Elena Sugrue, Matthew L. Turnbull, Isaric C-Investigators, Colin Loney, Monique Freire Santana, Jay Allan, Luiz Carlos de Lima Ferreira, Spyros Lytras, Antonia Ho, Natalia Cameron-Ruiz, Richard J. Stanton, Ruth F. Jarrett, Vanessa Herder, Arthur Wickenhagen, Innes Jarmson, Bo Wang, Sara Clohisey, Edward Chung Yern Wang, Matthias Marti, Massimo Palmarini, Kenneth Baillie, Marko Noerenberg, Joao Luiz Da Silva Filho, Douglas G. Stewart, Margus Varjak, Edward J. D. Greenwood, Simon Swingler
Cell autonomous antiviral defenses can inhibit the replication of viruses and reduce transmission and disease severity. To better understand the antiviral response to SARS-CoV-2, we used interferon-stimulated gene (ISG) expression screening to reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd517e51ccb503d025f6bea1c5a2cbb
https://doi.org/10.1101/2021.05.05.21256681
https://doi.org/10.1101/2021.05.05.21256681