Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Elena Simoni"'
Autor:
Melania Maria Serafini, Michele Catanzaro, Francesca Fagiani, Elena Simoni, Roberta Caporaso, Marco Dacrema, Irene Romanoni, Stefano Govoni, Marco Racchi, Maria Daglia, Michela Rosini, Cristina Lanni
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Nrf2 is a basic leucine zipper transcription factor that binds to the promoter region of the antioxidant response element (ARE), inducing the coordinated up-regulation of antioxidant and detoxification genes. We recently synthesized a set of new mole
Externí odkaz:
https://doaj.org/article/c4b3a8f75e1d4a279497276bebd66ecc
Autor:
Marcella Pighi, Giancarlo Pontoni, Arianna Sinisi, Silvia Ferrari, Giorgio Mattei, Luca Pingani, Elena Simoni, Gian Maria Galeazzi
Publikováno v:
Brain Sciences, Vol 8, Iss 11, p 197 (2018)
International media has paid attention to the use of substances by healthy subjects to enhance cognitive performance. Medical students are liable to use cognitive enhancers (CE) with the aim of improving academic performance. The study explored use a
Externí odkaz:
https://doaj.org/article/c4964d9a79ea4d75bf09d2d12fab2b80
Publikováno v:
Bulletin of Earthquake Engineering. 21:3321-3356
UnReinforced Masonry (URM) buildings constitute the majority of the Italian building stock and represent one of the most vulnerable construction typologies, as emerged during the seismic events occurred in the last decades. The objective of the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27eedda8cd7d193551f8552dde9c08b9
https://doi.org/10.1007/s10518-023-01636-8
https://doi.org/10.1007/s10518-023-01636-8
Estimates of the earthquake ground motion intensity over a geographical area have multiple uses, that is, emergency management, civil protection and seismic fragility assessment. In particular, with reference to fragility assessment, it is of interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dba2eb0357bf1cbdf8a37926ee2f84
https://hdl.handle.net/11585/904928
https://hdl.handle.net/11585/904928
Seismic fragility models are important elements for risk prediction, loss-estimation and emergency planning, because they define the relationship between different damage levels and the intensity of ground-shaking. These models can be obtained using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::e4c774ea686f4183de70ad71e950f6df
http://hdl.handle.net/11585/798808
http://hdl.handle.net/11585/798808
Autor:
M. Pighi, Gian Maria Galeazzi, Isotta Landi, Elena Simoni, Giulia Landi, Maria Moscara, Rosaria Di Lorenzo, Paola Ferri
Several studies support group therapy effectiveness due to the activation in patients of unique psychological mechanisms defined as non-specific therapeutic factors (Therapeutic Factors-TFs), which shape the setting and, at the same time, enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e1fb25d2f949e23b1c142c6728361
https://hdl.handle.net/11380/1208224
https://hdl.handle.net/11380/1208224
Publikováno v:
Proceedings of the 8th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering (COMPDYN 2015).
In the immediate aftermath of an earthquake, it is essential that emergency plans and damage scenarios are available so that civil protection agencies and risk-management organizations can detect and contain critical situations. These tools rely on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5981c99510513caff4e66f4379df552d
https://doi.org/10.7712/120121.8713.18672
https://doi.org/10.7712/120121.8713.18672
Autor:
Michela Rosini, Elena Simoni, Marco Racchi, Melania Maria Serafini, Cristina Lanni, Manuela Bartolini, Chiara Marchetti, Anna Minarini, Roberta Caporaso
Publikováno v:
ACS Chemical Neuroscience. 8:1618-1627
Amyloid is a prominent feature of Alzheimer's disease (AD). Yet, a linear linkage between amyloid-β peptide (Aβ) and the disease onset and progression has recently been questioned. In this context, the crucial partnership between Aβ and Nrf2 pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420e7f97d0a11c57ef165613c1557171
https://doi.org/10.1021/acschemneuro.7b00100
https://doi.org/10.1021/acschemneuro.7b00100
Autor:
Anna Minarini, Sara Masuzzo, Cristina Lanni, Filippo Basagni, Elena Simoni, Michela Rosini, Federica Fusco, Roberta Caporaso, Francesca Fagiani, Ian R. Mellor, Diego Albani, Izuddin Fahmy Abu, Michele Catanzaro
Publikováno v:
European journal of medicinal chemistry. 180
N-methyl- d -aspartate receptors (NMDAR) are critically involved in the pathogenesis of Alzheimer's disease (AD). Acting as an open-channel blocker, the anti-AD drug memantine preferentially targets NMDAR overactivation, which has been proposed to tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b6541e9370f8ab76ae43168000880
https://pubmed.ncbi.nlm.nih.gov/31301562
https://pubmed.ncbi.nlm.nih.gov/31301562
Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate
Autor:
Benedetta Nicolini, Alessio Lodola, Marco Mor, Nicole Ticchi, Andrea Milelli, Anna Minarini, Chiara Marchetti, Vincenzo Tumiatti, Elena Simoni, Andrea Tarozzi, Letizia Pruccoli, Massimo D’Amico
Publikováno v:
European Journal of Medicinal Chemistry. 117:283-291
Epidermal growth factor receptor inhibitors (EGFR-TKIs) represent a class of compounds widely used in anticancer therapy. An increasing number of studies reports on combination therapies in which the block of the EGFR-TK activity is associated with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f39690dd8eb8543a163871d2150b9a
https://doi.org/10.1016/j.ejmech.2016.04.002
https://doi.org/10.1016/j.ejmech.2016.04.002