Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene

Autor: Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Denis A. Tarasevich, Sophia V. Pavlova, Kamila R. Valetdinova, Julia M. Minina, Suren M. Zakian, Anastasia A. Malakhova

Publikováno v: Biomedicines, Vol 12, Iss 4, p 744 (2024)

Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative diseases, in particular Parkinson’s disease (PD). Since there is curren

Externí odkaz: https://doaj.org/article/40ac1f132b0c46d1bfe312659914ee7f

Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease.

Autor: Kopytova, Alena E.^1,2 (AUTHOR) kopytovaalena@mail.ru, Rychkov, George N.^1,3 (AUTHOR), Cheblokov, Alexander A.¹ (AUTHOR), Grigor'eva, Elena V.^4,5 (AUTHOR), Nikolaev, Mikhail A.^1,2 (AUTHOR), Yarkova, Elena S.⁴ (AUTHOR), Sorogina, Diana A.⁴ (AUTHOR), Ibatullin, Farid M.¹ (AUTHOR), Baydakova, Galina V.⁶ (AUTHOR), Izyumchenko, Artem D.^1,2 (AUTHOR), Bogdanova, Daria A.¹ (AUTHOR), Boitsov, Vitali M.⁷ (AUTHOR), Rybakov, Akim V.⁸ (AUTHOR), Miliukhina, Irina V.^1,8 (AUTHOR), Bezrukikh, Vadim A.⁹ (AUTHOR), Salogub, Galina N.⁹ (AUTHOR), Zakharova, Ekaterina Y.⁶ (AUTHOR), Pchelina, Sofya N.^1,2 (AUTHOR), Emelyanov, Anton K.^1,2 (AUTHOR) e_anton_gen@mail.ru

Publikováno v: International Journal of Molecular Sciences. May2023, Vol. 24 Issue 10, p9105. 17p.

Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene.

Autor: Yarkova, Elena S., Grigor'eva, Elena V., Medvedev, Sergey P., Tarasevich, Denis A., Pavlova, Sophia V., Valetdinova, Kamila R., Minina, Julia M., Zakian, Suren M., Malakhova, Anastasia A.

Publikováno v: Biomedicines; Apr2024, Vol. 12 Issue 4, p744, 23p

Researchers at Novosibirsk State University Zero in on Parkinson's Disease (IPSC-Derived Astrocytes Contribute to In Vitro Modeling of Parkinson's Disease Caused by the GBA1 N370S Mutation).

Publikováno v: Blood Weekly; 1/25/2024, p323-323, 1p

Study Findings on Genetic Risk Published by a Researcher at Laboratory of Nanobiotechnology (Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant b-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in...).

Publikováno v: Drug Week; 6/16/2023, p2906-2906, 1p