Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elena S. Stavridi"'
Autor:
Soheila Emamzadah, Thanos D. Halazonetis, Jeffery G. Saven, Tom J. Petty, Lorenzo Costantino, Irina Petkova, Elena S. Stavridi, Eric Vauthey
Publikováno v:
The EMBO Journal. 30:2167-2176
The p53 tumour suppressor gene, the most frequently mutated gene in human cancer, encodes a transcription factor that contains sequence-specific DNA binding and homo-tetramerization domains. Interestingly, the affinities of p53 for specific and non-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a44c5626d5eaed4f2fada5b6ce363c
https://doi.org/10.1038/emboj.2011.127
https://doi.org/10.1038/emboj.2011.127
Autor:
Richard A. DiTullio, Emily A. Sheston, Yentram Huyen, Hestia S. Mellert, Thanos D. Halazonetis, Elena S. Stavridi, Omar Zgheib, Panayotis Zacharatos, Vassilis G. Gorgoulis, Tom J. Petty
Publikováno v:
Nature. 432:406-411
The mechanisms by which eukaryotic cells sense DNA double-strand breaks (DSBs) in order to initiate checkpoint responses are poorly understood. 53BP1 is a conserved checkpoint protein with properties of a DNA DSB sensor. Here, we solved the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4be40d26653500435b836021f004a25
https://doi.org/10.1038/nature03114
https://doi.org/10.1038/nature03114
Autor:
Thanos D. Halazonetis, W. Brent Derry, Joel H. Rothman, Elena S. Stavridi, Nikola P. Pavletich, Yentram Huyen, Philip D. Jeffrey
Publikováno v:
Structure. 12:1237-1243
The DNA binding domains of human p53 and Cep-1, its C. elegans ortholog, recognize essentially identical DNA sequences despite poor sequence similarity. We solved the three-dimensional structure of the Cep-1 DNA binding domain in the absence of DNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39056653559e682800931c5ccc7d67b8
https://doi.org/10.1016/j.str.2004.05.007
https://doi.org/10.1016/j.str.2004.05.007
Publikováno v:
Genes & Development. 18:241-244
The p53 tumor suppressor is one of the central players in the response of cells to various forms of stress. Clearly, the main form of stress that activates p53 is genotoxic stress in the form of DNA double-strand breaks (DSBs) or stalled DNA replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccddee2a8c25d854d52c3d6ef5e837c7
https://doi.org/10.1101/gad.1181704
https://doi.org/10.1101/gad.1181704
Autor:
Nikola P. Pavletich, John Bothos, Steve E Stayrook, Philip D. Jeffrey, Yentram Huyen, Kimberly G. Harris, Peter-Mark Verwoerd, Francis C. Luca, Elena S. Stavridi
Publikováno v:
Structure. 11(9):1163-1170
The Mob protein family comprises a group of highly conserved eukaryotic proteins whose founding member functions in the mitotic exit network. At the molecular level, Mob proteins act as kinase-activating subunits. We cloned a human Mob1 family member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ae705664daabb4b808e3a2a263fe82
Autor:
Nikola P. Pavletich, Philip D. Jeffrey, Thanos D. Halazonetis, Yentram Huyen, Daniel M. Scolnick, Ivy R. Loreto, Elena S. Stavridi
Publikováno v:
Structure. 10:891-899
The Chfr mitotic checkpoint protein is frequently inactivated in human cancer. We determined the three-dimensional structure of its FHA domain in its native form and in complex with tungstate, an analog of phosphate. The structures revealed a β sand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737ea27fd84096dc3e4bf5df54f6304
https://doi.org/10.1016/s0969-2126(02)00776-1
https://doi.org/10.1016/s0969-2126(02)00776-1
Publikováno v:
Journal of Cellular Physiology. 190:365-374
Although p53 responses after DNA damage have been investigated extensively, p53 responses after heat shock, which exerts cytotoxic action by mechanisms other than direct induction of DNA damage, are less well characterized. We investigated, therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48c27a88681cb8eafb871cdebe0cd00
https://doi.org/10.1002/jcp.10069
https://doi.org/10.1002/jcp.10069
Autor:
Asra Malikzay, Richard A. DiTullio, Nabil H. Chehab, L.B. Schultz, Thanos D. Halazonetis, Elena S. Stavridi
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 65:489-498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa64d8403e078d08e45c963d729cad1b
https://doi.org/10.1101/sqb.2000.65.489
https://doi.org/10.1101/sqb.2000.65.489
Publikováno v:
Protein Science. 8:1773-1779
The tumor suppressor function of the wild-type p53 protein is transdominantly inhibited by tumor-derived mutant p53 proteins. Such transdominant inhibition limits the prospects for gene therapy approaches that aim to introduce wild-type p53 into canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346752df43305f81809e4af78da2a374
https://doi.org/10.1110/ps.8.9.1773
https://doi.org/10.1110/ps.8.9.1773
Publikováno v:
Nature Cell Biology. 7:648-650
The Nbs1 protein participates in the cell-cycle checkpoint response to DNA double-strand breaks (DSBs), but its precise mode of action — especially in relation to the checkpoint kinase Atm — has been debated. New mouse models suggest that Nbs1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::101bc3a9c1ea18780c1962f9e34bd388
https://doi.org/10.1038/ncb0705-648
https://doi.org/10.1038/ncb0705-648