Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Elena S. Nikonova"'
Autor:
Mani Mahmoudian, Elena S. Nikonova, Aimee E. Willett, Puya Aravand, Manzar Ashtari, Jean Bennett, Gui-Shuang Ying, Wei Pan, Kathleen A. Marshall, Albert M. Maguire, Gloria J. Young
Publikováno v:
Ophthalmology. 124:873-883
Purpose Gene therapy (GT) has offered immense hope to individuals who are visually impaired because of RPE65 mutations. Although GT has shown great success in clinical trials enrolling these individuals, evidence for stability and durability of this
Autor:
Arkady Lyubarsky, Anuradha Dhingra, Robert G. Smith, Xi-Qin Ding, Noga Vardi, Elena S. Nikonova, Abhishek Sengupta, Chidambaram Chinniah, Edward N. Pugh, Sergei Nikonov, Marie E. Fina
Publikováno v:
The Journal of Neuroscience. 33:5182-5194
Mammalian cones respond to light by closing a cGMP-gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Gαt2, Gβ3 and Gγt2 subunits. The function of Gβγ in this cascade has not been examined. Here, we
Autor:
Philip A. Cook, David Leopold, James C. Gee, Gloria J. Young, Laura Cyckowski, Hui Zhang, Jean Bennett, Manzar Ashtari, Elena S. Nikonova, Kathleen A. Marshall, Chris I. Baker, Albert M. Maguire
Publikováno v:
Molecular Therapy. 24:S105
Leber's Congenital Amaurosis (LCA) is an incurable eye disease. Due to slow retinal degeneration, LCA patients with RPE65 gene mutations (LCA2) are good candidates for gene therapy (GT). LCA2 patients in a Phase 1 clinical trial showed improvement in