Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elena S. Haight"'
Autor:
Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha M. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113683- (2024)
Summary: Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. To clarify the specific contribution of microglia
Externí odkaz:
https://doaj.org/article/2e3aed2af006405d84986f37d5ad267b
Autor:
Nolan A. Huck, Lauren J. Donovan, Huaishuang Shen, Claire E. Jordan, Gabriella P.B. Muwanga, Caldwell M. Bridges, Thomas E. Forman, Stephanie A. Cordonnier, Elena S. Haight, Fiona Dale-Huang, Yoshinori Takemura, Vivianne L. Tawfik
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100106- (2022)
Chronic pain is a common and often debilitating problem that affects 100 million Americans. A better understanding of pain’s molecular mechanisms is necessary for developing safe and effective therapeutics. Microglial activation has been implicated
Externí odkaz:
https://doaj.org/article/3530f064f537414992f24a30d917900d
Publikováno v:
PAIN Reports, Vol 5, Iss 5, p e841 (2020)
Abstract. Introduction:. Complex regional pain syndrome (CRPS) is a condition that occurs after minor trauma characterized by sensory, trophic, and motor changes. Although preclinical studies have demonstrated that CRPS may be driven in part by autoi
Externí odkaz:
https://doaj.org/article/ed8454a3c3f045f58bf6a1e1ac2d8feb
Autor:
Vivianne L. Tawfik, Nolan A. Huck, Quentin J. Baca, Edward A. Ganio, Elena S. Haight, Anthony Culos, Sajjad Ghaemi, Thanaphong Phongpreecha, Martin S. Angst, J. David Clark, Nima Aghaeepour, Brice Gaudilliere
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Many diseases display unequal prevalence between sexes. The sex-specific immune response to both injury and persistent pain remains underexplored and would inform treatment paradigms. We utilized high-dimensional mass cytometry to perform a comprehen
Externí odkaz:
https://doaj.org/article/42e6d8e6c56645c2888e62a3a7e55c3c
Autor:
Lauren J. Donovan, Caldwell M. Bridges, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Sabrina F. Bond, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
SummaryMicroglia contribute to the initiation of pain, however, a translationally viable approach addressing how or when to modulate these cells remains elusive. We used a targeted, inducible, genetic microglial depletion strategy at both acute and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76778da93eaa96c2bf6298953294e7f
https://doi.org/10.1101/2022.12.20.521295
https://doi.org/10.1101/2022.12.20.521295
Autor:
Caldwell M. Bridges, Lauren J. Donovan, Amy R. Nippert, Meng Wang, Shaogen Wu, Thomas E. Forman, Elena S. Haight, Nolan A. Huck, Claire E. Jordan, Aysha S. Gardner, Ramesh V. Nair, Vivianne L. Tawfik
Publikováno v:
The Journal of Pain. 24:5-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb2aea23322ff33ffb2fa165eaf0e47
https://doi.org/10.1016/j.jpain.2023.02.020
https://doi.org/10.1016/j.jpain.2023.02.020
Autor:
Vivianne L. Tawfik, Elena S. Haight, Jasmine Kaslow, Angel Amadeus Ortiz, Janelle Siliezar-Doyle, Gabriella P. B. Muwanga
Publikováno v:
Journal of Visualized Experiments.
The tibial fracture-pin model is a mouse model of orthopedic trauma and surgery that recapitulates the complex muscle, bone, nerve, and connective tissue damage that manifests with this type of injury in humans. This model was developed because previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3fab30395074f545246f06c6a25094
https://doi.org/10.3791/63590
https://doi.org/10.3791/63590
Publikováno v:
Complex Regional Pain Syndrome ISBN: 9783030753726
Complex regional pain syndrome (CRPS) is a chronic pain condition that usually follows minor extremity trauma and is characterized by sensory, vasomotor, sudomotor, and motor/trophic changes. While epidemiological studies are limited, CRPS occurs wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fdd89bf7bb7fbd812f8f4fef0eaa792
https://doi.org/10.1007/978-3-030-75373-3_1
https://doi.org/10.1007/978-3-030-75373-3_1
Autor:
J. David Clark, Huaishuang Shen, Vivianne L. Tawfik, Ryosuke Ishida, Janelle Siliezar-Doyle, Elena S. Haight, Shaogen Wu, Yoshinori Takemura, Thomas E. Forman, Nolan A. Huck
Publikováno v:
J Neurosci
Complex regional pain syndrome (CRPS) is a chronic pain disorder with a clear acute-to-chronic transition. Preclinical studies demonstrate that toll-like receptor 4 (TLR4), expressed by myeloid-lineage cells, astrocytes, and neurons, mediates a sex-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f3121b9e292046aa789c0636418afb
https://pubmed.ncbi.nlm.nih.gov/33846230
https://pubmed.ncbi.nlm.nih.gov/33846230
Publikováno v:
Pain Reports
PAIN Reports, Vol 5, Iss 5, p e841 (2020)
PAIN Reports, Vol 5, Iss 5, p e841 (2020)
We present a case series of patients treated with hydroxychloroquine for complex regional pain syndrome and demonstrated analgesia and reduced spinal cord autoinflammation in a preclinical model of complex regional pain syndrome.
Introduction: C
Introduction: C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedbbe736fc6803324954a41b2632b19
https://pubmed.ncbi.nlm.nih.gov/33490839
https://pubmed.ncbi.nlm.nih.gov/33490839