Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elena R. Bovolenta"'
Autor:
Marta Iborra-Pernichi, Jonathan Ruiz García, María Velasco de la Esperanza, Belén S. Estrada, Elena R. Bovolenta, Claudia Cifuentes, Cristina Prieto Carro, Tamara González Martínez, José García-Consuegra, María Fernanda Rey-Stolle, Francisco Javier Rupérez, Milagros Guerra Rodriguez, Rafael J. Argüello, Sara Cogliati, Fernando Martín-Belmonte, Nuria Martínez-Martín
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly underst
Externí odkaz:
https://doaj.org/article/d47fc4e2cc244f8d8109bd4b0197ce3c
Autor:
Elena R. Bovolenta, Eva M. García-Cuesta, Lydia Horndler, Julia Ponomarenko, Wolfgang W. Schamel, Mario Mellado, Mario Castro, David Abia, Hisse M. van Santen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage choice, and ability to re
Autor:
Julia Ponomarenko, Hisse M. van Santen, Mario Castro, Elena R. Bovolenta, Eva M. García-Cuesta, Mario Mellado, David Abia
Signaling via pre-TCR is essential for initial T cell differentiation. How the signal is triggered and whether its alteration impacts on lymphocyte repertoires is nevertheless debated. We show that a mutation in the transmembrane domain of the CD3ζ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514e051c6e4ffd2ffcd734fd0853daa6
Autor:
Clara L. Oeste, Cristina Prieto, Viola L. Boccasavia, Diego Alonso-López, Facundo D. Batista, Manuel D. Díaz-Muñoz, Elena R. Bovolenta, Aldo Borroto, Balbino Alarcon
Publikováno v:
SSRN Electronic Journal.
T cells form immunological synapses with professional antigen presenting cells (APCs) resulting not only in T cell activation but also in the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC becoming APCs themse
Autor:
Elena R. Bovolenta, Julia Ponomarenko, Viola L. Boccasavia, Balbino Alarcón, David Abia, Clara L. Oeste, Hisse M. van Santen, Ana Martínez-Riaño, Manuel Fresno
Publikováno v:
The Journal of Experimental Medicine
RRAS2 is involved in setting the threshold for negative selection of T cells in the thymus. In its absence, most autoreactive T cells are eliminated, and, consequently, mice become resistant to development of autoimmune diseases in experimental model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a142ca4729ab6b2e14ad4edaf4bcab12
http://hdl.handle.net/10230/53093
http://hdl.handle.net/10230/53093
Autor:
Ana Martínez-Riaño, Nuria Martínez-Martín, María Jesús Martín-Bermejo, Balbino Alarcón, Elena R. Bovolenta, Paola Bovolenta, Clara L. Oeste, Martin R Turner, Pilar Mendoza
Publikováno v:
EMBO Reports
Successful vaccines rely on activating a functional humoral response that results from promoting a proper germinal center (GC) reaction. Key in this process is the activation of follicular B cells that need to acquire antigens and to present them to
Autor:
Clara L. Oeste, Nuria Martínez-Martín, Pilar Delgado, Pilar Mendoza, Elena R. Bovolenta, Balbino Alarcón, Tomohiro Kurosaki, Pablo Hernansanz-Agustín, Xosé R. Bustelo, Manuel D. Díaz-Muñoz, Antonio Martínez-Ruiz, Isabel Fernández-Pisonero, Eugenio Santos, Ester Castellano, Diego Alonso-López, Diana Reyes-Garau
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Upon antigen recognition within peripheral lymphoid organs, B cells interact with T cells and other immune cells to transiently form morphological structures called germinal centers (GCs), which are required for B cell clonal expansion, immunoglobuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cfc400395b57c24659958da85f59ce
http://hdl.handle.net/10261/169371
http://hdl.handle.net/10261/169371
Autor:
Celia Alda-Catalinas, Clara L. Oeste, Nadia Martin-Blanco, Wolfgang W. A. Schamel, Ed Palmer, Grant Lythe, Mario Castro, Raquel Blanco, Elena R. Bovolenta, Balbino Alarcón, Carmen Molina-París
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
instname
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The T-cell antigen receptor (TCR) is pre-organised in oligomers, known as nanoclusters. Nanoclusters could provide a framework for inter-TCR cooperativity upon peptide antigen-major histocompatibility complex (pMHC) binding. Here we have used soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8b1e0e75ced09a660d770733a62e61
http://hdl.handle.net/10261/178673
http://hdl.handle.net/10261/178673
Autor:
Sandra Lasarte, Adela Matesanz-Marín, Jose R. Cortes, Raquel Sánchez-Díaz, María L. Toribio, Pilar Martín, Elena R. Bovolenta, Francisco Sánchez-Madrid, Olga Barreiro
Publikováno v:
Journal of Autoimmunity
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Although FoxP3+ regulatory T cells are key players in the maintenance of immune tolerance and autoimmunity, the lack of specific markers constitute an obstacle to their use for immunotherapy protocols. In this study, we have investigated the role of