Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Elena Pini"'
Publikováno v:
Molbank, Vol 2024, Iss 2, p M1806 (2024)
In the context of our ongoing studies on chromane derivatives as inhibitors of the salicylate synthase from M. tuberculosis, we isolated a new, unexpected compound from the cyclization of 3-(propargyloxy)-5-benzyloxy-benzoic acid methyl ester. Its mo
Externí odkaz:
https://doaj.org/article/165072210f2f470db8aa40ba46e76957
Autor:
Luca Casula, Rosa Pireddu, Maria Cristina Cardia, Elena Pini, Donatella Valenti, Michele Schlich, Chiara Sinico, Salvatore Marceddu, Nina Dragićević, Anna Maria Fadda, Francesco Lai
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2308 (2023)
Applying a formulation on the skin represents a patient-acceptable and therapeutically effective way to administer drugs locally and systemically. However, the stratum corneum stands as an impermeable barrier that only allows a very limited number of
Externí odkaz:
https://doaj.org/article/2b2326eefe3d41fa8c845a2b030e602d
Autor:
Serena Delbue, Elena Pariani, Silvia Parapini, Cristina Galli, Nicoletta Basilico, Sarah D’Alessandro, Sara Pellegrino, Elena Pini, Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti
Publikováno v:
Molecules, Vol 28, Iss 6, p 2848 (2023)
Lysozyme (E.C. 3.2.1.17), an about 14 kDa protein and pI 11, widely spread in nature, is present in humans mainly in milk, saliva, and intestinal mucus as a part of innate defense mechanisms. It is endowed with antimicrobial activity due to its actio
Externí odkaz:
https://doaj.org/article/4f92bd36551a4faf955ec76a98c077f9
Autor:
Matteo Mori, Giovanni Stelitano, Anna Griego, Laurent R. Chiarelli, Giulia Cazzaniga, Arianna Gelain, Elena Pini, Marina Camera, Paola Canzano, Andrea Fumagalli, Edoardo Scarpa, Chiara Cordiglieri, Loris Rizzello, Stefania Villa, Fiorella Meneghetti
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 992 (2022)
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of M. tuberculosis (Mtb) have developed resistance against most of the established anti-TB
Externí odkaz:
https://doaj.org/article/a89679d5dd8a4796a26f8260240379b5
Autor:
Laurent R. Chiarelli, Matteo Mori, Giangiacomo Beretta, Arianna Gelain, Elena Pini, Josè Camilla Sammartino, Giovanni Stelitano, Daniela Barlocco, Luca Costantino, Margherita Lapillo, Giulio Poli, Isabella Caligiuri, Flavio Rizzolio, Marco Bellinzoni, Tiziano Tuccinardi, Stefania Villa, Fiorella Meneghetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 823-828 (2019)
Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro moiety, leading to the disclosure of a new lead exhibiting a strong activity against MbtI. Ou
Externí odkaz:
https://doaj.org/article/6ba177ad0ffa4fc28c89f33af7982d70
Autor:
Matteo Mori, Fiorella Meneghetti, Laurent R. Chiarelli, Alessia Diego, Donatella Nava, Arianna Gelain, Giulia Cazzaniga, Stefania Villa, Elena Pini
Publikováno v:
Molbank, Vol 2020, Iss 2, p M1143 (2020)
6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. I
Externí odkaz:
https://doaj.org/article/3964dd44d37c4695a270d3f73bae04a3
Autor:
Luca Casula, Francesco Lai, Elena Pini, Donatella Valenti, Chiara Sinico, Maria Cristina Cardia, Salvatore Marceddu, Giorgia Ailuno, Anna Maria Fadda
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1300 (2021)
Curcumin has shown a potential extraordinary activity as an add-on ingredient in asthma treatment, due to its immunomodulatory and anti-inflammatory mechanism of action. However, its low water solubility and bioavailability lead to a poor therapeutic
Externí odkaz:
https://doaj.org/article/5bd777547c0c49cf87fff4f6fcfb38e2
Autor:
Matteo Mori, Giovanni Stelitano, Laurent R. Chiarelli, Giulia Cazzaniga, Arianna Gelain, Daniela Barlocco, Elena Pini, Fiorella Meneghetti, Stefania Villa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 155 (2021)
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the establish
Externí odkaz:
https://doaj.org/article/9b85a7096bf347e7aa5d0a78f21d473e
Autor:
Rosa Pireddu, Michele Schlich, Salvatore Marceddu, Donatella Valenti, Elena Pini, Anna Maria Fadda, Francesco Lai, Chiara Sinico
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1140 (2020)
Topical application of the anti-inflammatory drug diclofenac (DCF) reduces the severity of systemic unwanted effects compared to its oral administration. A number of transdermal formulations are available on the market and routinely used in clinical
Externí odkaz:
https://doaj.org/article/71d35a53a4cb43dea63233bd7c974ab3
Autor:
Elena Pini, Giulio Poli, Tiziano Tuccinardi, Laurent Roberto Chiarelli, Matteo Mori, Arianna Gelain, Luca Costantino, Stefania Villa, Fiorella Meneghetti, Daniela Barlocco
Publikováno v:
Molecules, Vol 23, Iss 7, p 1506 (2018)
Tuberculosis is the leading cause of death from a single infectious agent worldwide; therefore, the need for new antitubercular drugs is desperate. The recently validated target salicylate synthase MbtI is the first enzyme involved in the biosynthesi
Externí odkaz:
https://doaj.org/article/9ae7d197351a4e6e8bd277cbc651bdc8