Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Elena Peeva"'
Autor:
Spencer I. Danto, Nikolaos Tsamandouras, Padma Reddy, Steven A. Gilbert, Jessica Y. Mancuso, Karen Page, Jean S. Beebe, Elena Peeva, Michael S. Vincent
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-8 (2024)
Abstract PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the pharmacodynamics and clinical effects of single and repeat doses of PF-06817024 was assessed in
Externí odkaz:
https://doaj.org/article/342daf6733c54dea9222dbbb5a9d74c3
Autor:
Stanley Cohen, Jean S. Beebe, Vishala Chindalore, Shunjie Guan, Mina Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig Hyde, Sarita Koride, Robert Levin, Shannon Lubaczewski, Mikhail Salganik, Abigail Sloan, Erin Stevens, Elena Peeva, Michael S. Vincent, David A. Martin, Myron Chu
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Background The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 (CXCR5
Externí odkaz:
https://doaj.org/article/de4e6e08230342d8a8ccd262c81c4143
Autor:
Anna Swenson, Jessica K. Paulus, Yoojin Jung, Stefan Weiss, Brian Berman, Elena Peeva, Yuji Yamaguchi, Prethibha George, Oladayo Jagun
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 1, Pp 131-149 (2023)
Abstract Introduction Keloids are lesions characterized by the growth of dense fibrous tissue extending beyond original wound boundaries. Research into the natural history of keloids and potential differences by sociodemographic factors in the USA is
Externí odkaz:
https://doaj.org/article/f8cf5803a2274137b6d9c94c2c7be3be
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4409 (2024)
Both alopecia areata (AA) and vitiligo are distinct, heterogenous, and complex disease entities, characterized by nonscarring scalp terminal hair loss and skin pigment loss, respectively. In AA, inflammatory cell infiltrates are in the deep reticular
Externí odkaz:
https://doaj.org/article/79d1ba6d397647ac99748f45fedfc0a0
Autor:
Li Xi, Sandra Garcet, Zhan Ye, Kenneth Hung, Mina Hassan-Zahraee, Elizabeth Kieras, James G. Krueger, Craig Hyde, Elena Peeva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Despite multiple efficacious therapies in common between psoriasis (PS) and Ulcerative Colitis (UC), mechanisms underlying their common pathophysiology remain largely unclear. Here we sought to establish a link by evaluating expression diffe
Externí odkaz:
https://doaj.org/article/f2776b8b8cd2456abd8d222a0dbf6c07
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12975 (2023)
Our understanding of allergic contact dermatitis mechanisms has progressed over the past decade. Innate immune cells that are involved in the pathogenesis of allergic contact dermatitis include Langerhans cells, dermal dendritic cells, macrophages, m
Externí odkaz:
https://doaj.org/article/ad95ffef060c490ab9d602b841a64c78
Autor:
Brett King, Emma Guttman-Yassky, Elena Peeva, Anindita Banerjee, Linda Zhu, Hua Zhu, Lori Ann Cox, Michael S. Vincent, Rodney Sinclair
Publikováno v:
JID Innovations, Vol 2, Iss 6, Pp 100156- (2022)
The 24-week, double-blind period of the ALLEGRO phase 2a trial (NCT02974868) evaluated the safety and efficacy of ritlecitinib (Jak3/tyrosine kinase expressed in the hepatocellular carcinoma inhibitor) and brepocitinib (tyrosine kinase 2/Jak1 inhibit
Externí odkaz:
https://doaj.org/article/0116e2d715b245428d9d62d101f6f5d4
Autor:
Ravi Shankar P. Singh, Vivek Pradhan, Erika S. Roberts, Matthew Scaramozza, Elizabeth Kieras, Jeremy D. Gale, Elena Peeva, Michael S. Vincent, Anindita Banerjee, Andrew Fensome, Martin E. Dowty, Peter Winkle, Christopher Tehlirian
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 671-682 (2021)
Selective inhibition of tyrosine kinase 2 (TYK2) may offer therapeutic promise in inflammatory conditions, with its role in downstream pro‐inflammatory cytokine signaling. In this first‐in‐human study, we evaluated the safety, tolerability, and
Externí odkaz:
https://doaj.org/article/b2ae82b7680a48168cc227d391573f2e
Autor:
Philip Mease, Philip Helliwell, Paula Silwinska‐Stanczyk, Malgorzata Miakisz, Andrew Ostor, Elena Peeva, Michael S. Vincent, Qiankun Sun, Vanja Sikirica, Randall Winnette, Ruolun Qiu, Gang Li, Gang Feng, Jean S. Beebe, David A. Martin
Publikováno v:
Arthritis & Rheumatology.