Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elena Pedraz-Cuesta"'
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Autor:
Ruth Hendus-Altenburger, Xinru Wang, Lise M. Sjøgaard-Frich, Elena Pedraz-Cuesta, Sarah R. Sheftic, Anne H. Bendsøe, Rebecca Page, Birthe B. Kragelund, Stine F. Pedersen, Wolfgang Peti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The mechanism by which Ser/Thr protein phosphatases specifically recruit and dephosphorylate their substrates is largely unclear. Hear, the authors elucidate how the Ser/Thr protein phosphatase calcineurin is recruited to its substrate NHE1 and how s
Externí odkaz:
https://doaj.org/article/5e565aa376cd44bab46f43a617043caa
Autor:
Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen
Publikováno v:
Cells, Vol 9, Iss 2, p 465 (2020)
Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases) has been implicated in acid extrusion and invasivene
Externí odkaz:
https://doaj.org/article/3f069b3cd9134730a7e12715e3ff9504
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2475-2484 (2013)
Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver. Because previous studies have shown that human ADH1 enzymes may participate in bile acid metabolism, we investigated whe
Externí odkaz:
https://doaj.org/article/a0ada3cff88b43258fae9bebe97cacb3
Autor:
Maikel C. Rheinstädter, Stine F. Pedersen, Kimmie Gauger, Elena Pedraz-Cuesta, Morten E. Pedersen, Katrine Bugge, Birthe B. Kragelund, Adree Khondker, Ersoy Cholak, Annette Eva Langkilde, Bente Vestergaard, Saskia Bucciarelli
Publikováno v:
The FASEB Journal
Cholak, E, Bugge, K, Khondker, A, Gauger, K, Pedraz-Cuesta, E, Pedersen, M E, Bucciarelli, S, Vestergaard, B, Pedersen, S F, Rheinstädter, M C, Langkilde, A E & Kragelund, B B 2020, ' Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion ', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 34, no. 6, pp. 7462-7482 . https://doi.org/10.1096/fj.202000107R
Cholak, E, Bugge, K, Khondker, A, Gauger, K, Pedraz-Cuesta, E, Pedersen, M E, Bucciarelli, S, Vestergaard, B, Pedersen, S F, Rheinstädter, M C, Langkilde, A E & Kragelund, B B 2020, ' Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion ', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 34, no. 6, pp. 7462-7482 . https://doi.org/10.1096/fj.202000107R
In the brain, α-synuclein (aSN) partitions between free unbound cytosolic and membrane bound forms modulating both its physiological and pathological role and complicating its study due to structural heterogeneity. Here, we use an interdisciplinary,
Autor:
Nanditha Shyam Prasad, Jens Vogensen, Stine F. Pedersen, Marité Cárdenas, Ruth Hendus-Altenburger, Birthe B. Kragelund, Elena Pedraz-Cuesta, Emilie S Pedersen, Raul Araya-Secchi, Anne H. Bendsoe, Alessandra Luchini, Lise Arleth, Andreas Prestel
Publikováno v:
Hendus-Altenburger, R, Vogensen, J, Pedersen, E S, Luchini, A, Araya-Secchi, R, Bendsoe, A H, Prasad, N S, Prestel, A, Cardenas, M, Pedraz-Cuesta, E, Arleth, L, Pedersen, S H F & Kragelund, B B 2020, ' The intracellular lipid-binding domain of human Na + /H + exchanger 1 forms a lipid-protein co-structure essential for activity ', Communications Biology, vol. 3, no. 1, 731 . https://doi.org/10.1038/s42003-020-01455-6
Communications Biology
Communications Biology
Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly overlooked in membrane proteins. The ubiquitously expressed membrane protein Na+/H+-exchanger 1 (NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334005090442e757ab4e4672536ac7b8
http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-37152
http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-37152
Autor:
Marc Severin, Sofie Hagelund, Ivana Novak, Stine F. Pedersen, Christian Stock, Andrej Gorbatenko, Elena Pedraz-Cuesta, Mette Flinck
Publikováno v:
Cells
Volume 9
Issue 2
Flinck, M, Hagelund, S, Gorbatenko, A, Severin, M, Pedraz-Cuesta, E, Novak, I, Stock, C & Pedersen, S F 2020, ' The Vacuolar H + ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells ', Cells, vol. 9, no. 2, 465 . https://doi.org/10.3390/cells9020465
Cells, Vol 9, Iss 2, p 465 (2020)
Volume 9
Issue 2
Flinck, M, Hagelund, S, Gorbatenko, A, Severin, M, Pedraz-Cuesta, E, Novak, I, Stock, C & Pedersen, S F 2020, ' The Vacuolar H + ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells ', Cells, vol. 9, no. 2, 465 . https://doi.org/10.3390/cells9020465
Cells, Vol 9, Iss 2, p 465 (2020)
Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases) has been implicated in acid extrusion and invasivene
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2475-2484 (2013)
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver . Because previous studies have shown that human ADH1 enzymes may participate in bile acid metabolism, we investigated wh
Autor:
Stine F. Pedersen, Ruth Hendus-Altenburger, Birthe B. Kragelund, Elena Papaleo, Christina W. Olesen, Jeff A. Schnell, Elena Pedraz-Cuesta, Jonathan T. S. Hopper, Carol V. Robinson
Publikováno v:
BMC Biology
Hendus-Altenburger, R, Pedraz Cuesta, E, Olesen, C W, Papaleo, E, Schnell, J A, Hopper, J T S, Robinson, C V, Pedersen, S H F & Kragelund, B B 2016, ' The human Na + /H + exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 ', BMC Biology, vol. 14, 31 . https://doi.org/10.1186/s12915-016-0252-7
Hendus-Altenburger, R, Pedraz Cuesta, E, Olesen, C W, Papaleo, E, Schnell, J A, Hopper, J T S, Robinson, C V, Pedersen, S H F & Kragelund, B B 2016, ' The human Na + /H + exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 ', BMC Biology, vol. 14, 31 . https://doi.org/10.1186/s12915-016-0252-7
Background Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaff
Autor:
Jan Christiansen, Elena Pedraz-Cuesta, Christina W. Olesen, Stine F. Pedersen, Nathalie Loebl, Andrej Gorbatenko, Carolina Bianchi, Haraldur Heidar Sigurdsson
Publikováno v:
The Biochemical journal. 473(21)
The Na+–HCO3– cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768, in its 3′ untranslated region (3′UTR) correlates with increased breast cancer risk
Autor:
Nils Brünner, Stine F. Pedersen, Maria Unni Rømer, Sandra Christensen, Lennart Bunch, Elena Pedraz-Cuesta, Niels Frank Jensen, Jan Stenvang, Anders A. Jensen
Publikováno v:
Cuesta, E P, Christensen, S, Jensen, A A, Jensen, N F, Bunch, L, Rømer, M U K, Brünner, N, Stenvang, J & Pedersen, S H F 2015, ' The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38-and oxaliplatin-induced death of drug-resistant colorectal cancer cells ', B M C Cancer, vol. 15, no. 1, 411 . https://doi.org/10.1186/s12885-015-1405-8
BMC Cancer
BMC Cancer
Background Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed. Methods Here, we employed HCT116 and LoVo human CRC cells made resistant to either SN38 or oxaliplatin, to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f50a9331765b413b1438596dc002ab8
https://curis.ku.dk/ws/files/160998092/The_glutamate_transport_inhibitor.pdf
https://curis.ku.dk/ws/files/160998092/The_glutamate_transport_inhibitor.pdf