Výsledky vyhledávání - "Elena P. Moreno-Jiménez"

Akademický článek

An integration-free iPSC line, ICCSICi007-A, derived from a female Alzheimer's disease patient with the APOE-ε4/ε4 alleles

Autor: Eva Díaz-Guerra, Eva Rodríguez-Traver, Elena P. Moreno-Jiménez, Itziar de Rojas, César Rodríguez, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 41, Iss , Pp - (2019)

The epsilon4 (ε4) allele of the APOE gene, which encodes the apolipoprotein E4 (ApoE4), is the strongest genetic risk factor known for late-onset Alzheimer´s disease (LOAD). Here, we present the characterization of an iPSC line generated from derma

Externí odkaz: https://doaj.org/article/ab385c0261d1499db8825e7cd7e9ab7c

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Akademický článek

Generation of an integration-free iPSC line, ICCSICi006-A, derived from a male Alzheimer's disease patient carrying the PSEN1-G206D mutation

Autor: Eva Díaz-Guerra, Manuel A. Oria-Muriel, Elena P. Moreno-Jiménez, Itziar de Rojasb,, César Rodríguez, Eva Rodríguez-Traver, María Orera, Isabel Hernándezb,, Agustín Ruizb,, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 40, Iss , Pp - (2019)

The familial form of Alzheimer's disease (FAD), which is caused by mutations in PRESENILIN 1 (PSEN1) and amyloid precursor protein (APP) genes, represents less than 5% of all AD cases and has an early-onset. We report the generation and characterizat

Externí odkaz: https://doaj.org/article/dbb39638ed824d1c901ae2f5464bc1fd

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Akademický článek

A collection of four integration-free iPSC lines derived from diagnosed sporadic Alzheimer's disease patients with different APOE alleles

Autor: Eva Díaz-Guerra, Elena P. Moreno-Jiménez, Itziar de Rojas, César Rodríguez, Eva Rodríguez-Traver, Esther Arribas-González, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicario

Publikováno v: Stem Cell Research, Vol 39, Iss , Pp - (2019)

Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to late-onset Alzheimer's disease (LOAD). The ε3 allele of APOE, the most common isoform, does not represent a risk factor for LOAD. In contrast, the ε4 allele is t

Externí odkaz: https://doaj.org/article/8e2f1789e21148eebc02e9b45ee6d12f

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Akademický článek

The Social Component of Environmental Enrichment Is a Pro-neurogenic Stimulus in Adult c57BL6 Female Mice

Autor: Elena P. Moreno-Jiménez, Jerónimo Jurado-Arjona, Jesús Ávila, María Llorens-Martín

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

In rodents, the hippocampal dentate gyrus gives rise to newly generated dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), converges in the functional integration of mature DGCs into the trisynapti

Externí odkaz: https://doaj.org/article/d057576ab6cc4472999713005fb69abc

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Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

Autor: Fabio Cafini, C. B. Rodríguez-Moreno, Miguel Flor-García, Julia Terreros-Roncal, María Llorens-Martín, Mariela F. Trinchero, Elena P. Moreno-Jiménez, Alberto Rábano

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Science

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Hun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d327e8a097941d534883d775a01bba79
https://doi.org/10.1126/science.abl5163

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Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia

Autor: Alejandro F. Schinder, Miguel Flor-García, Damiana Giacomini, María Llorens-Martín, Alberto Rábano, Elena P. Moreno-Jiménez, Nirnath Sah, Jesús Avila, Henriette van Praag, Julia Terreros-Roncal, Noemí Pallas-Bazarra

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname

Frontotemporal dementia (FTD) is characterized by neuronal loss in the frontal and temporal lobes of the brain. Here, we provide the first evidence of striking morphological alterations in dentate granule cells (DGCs) of FTD patients and in a mouse m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4475166eb5ead5ee21bcf391a6662d
https://doi.org/10.1523/jneurosci.2724-18.2019

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Evidences for adult hippocampal neurogenesis in humans

Autor: Elena P. Moreno-Jiménez, Julia Terreros-Roncal, Miguel Flor-García, María Llorens-Martín, Alberto Rábano

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
J Neurosci

The rodent hippocampus generates new neurons throughout life. This process, named adult hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the brains of numerous mammalian species. Direct evidence of adult neurogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e48f8f513394af7f35eddcc3daf185c
http://hdl.handle.net/10261/264858

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