Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elena Mylonas"'
Autor:
Elena Mylonas, Kenichi Yoshida, Mareike Frick, Kaja Hoyer, Friederike Christen, Jaspal Kaeda, Matthias Obenaus, Daniel Noerenberg, Cornelius Hennch, Willy Chan, Yotaro Ochi, Yuichi Shiraishi, Yusuke Shiozawa, Thorsten Zenz, Christopher C. Oakes, Birgit Sawitzki, Michaela Schwarz, Lars Bullinger, Philipp le Coutre, Matthew J. J. Rose-Zerilli, Seishi Ogawa, Frederik Damm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.
Externí odkaz:
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37
Autor:
Laure Delestré, Hengxiang Cui, Michela Esposito, Cyril Quiveron, Elena Mylonas, Virginie Penard-Lacronique, Oliver Bischof, Christel Guillouf
Publikováno v:
Haematologica, Vol 102, Iss 11 (2017)
Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem
Externí odkaz:
https://doaj.org/article/1a68a84118264672aa964309f179e5bf
Autor:
Olivier A. Bernard, Florence Nguyen-Khac, Seishi Ogawa, Nathalie Droin, Thomas Mercher, William Vainchenker, Koichi Akashi, Eric Solary, Philippe Dessen, Laurent Sutton, Hélène Merle-Béral, Daniel Gautheret, Jérôme Lambert, Frederick Davi, Yoshikane Kikushige, Satoru Miyano, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Laurianne Scourzic, M'boyba Diop, Enguerran Mouly, Véronique Della Valle, Kenichi Yoshida, Adrien Cosson, Elena Mylonas, Frederik Damm
XLS file - 75KB, Details of signature and expression analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b97f1d81e45ec8af17f3b3b77670c0
https://doi.org/10.1158/2159-8290.22531780
https://doi.org/10.1158/2159-8290.22531780
Autor:
Olivier A. Bernard, Florence Nguyen-Khac, Seishi Ogawa, Nathalie Droin, Thomas Mercher, William Vainchenker, Koichi Akashi, Eric Solary, Philippe Dessen, Laurent Sutton, Hélène Merle-Béral, Daniel Gautheret, Jérôme Lambert, Frederick Davi, Yoshikane Kikushige, Satoru Miyano, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Laurianne Scourzic, M'boyba Diop, Enguerran Mouly, Véronique Della Valle, Kenichi Yoshida, Adrien Cosson, Elena Mylonas, Frederik Damm
PDF file - 126KB, Analyses of two patients with detectable SF3B1 mutations in CD19+, CD34+ and CD14+ fractions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb40303f3dc7723d7d789aa4274a583
https://doi.org/10.1158/2159-8290.22531801
https://doi.org/10.1158/2159-8290.22531801
Autor:
Christopher C. Oakes, Elena Mylonas, Yusuke Shiozawa, Lars Bullinger, Matthias Obenaus, Daniel Noerenberg, Mareike Frick, Michaela Schwarz, Matthew J. J. Rose-Zerilli, Kenichi Yoshida, Friederike Christen, Yotaro Ochi, Willy Chan, Frederik Damm, Jaspal Kaeda, Philipp le Coutre, Yuichi Shiraishi, Seishi Ogawa, Thorsten Zenz, Birgit Sawitzki, Kaja Hoyer, Cornelius Hennch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor
Autor:
Nathalie Droin, Philippe Rameau, Philippe Dessen, Florence Nguyen-Khac, Bilyana Stoilova, Elena Mylonas, Marine Armand, Damien Roos-Weil, Olivier Bernard, Els Verhoeyen, Paresh Vyas, Said Aoufouchi, Marlen Metzner, Françoise Pflumio, Frédéric Charlotte, Vincent Ribrag, Diane Lara, Olivier Elemento, Pierre Morel, Eric Durot, Cécile Hérate, Pascale Cornillet-Lefebvre, Véronique Della-Valle, Hussein Ghamlouch, Virginie Ropars, Frederik Damm, Nabih Azar, Christel Guillouf, François-Loïc Cosset, Camille Decaudin, Valérie Camara-Clayette, M'Boyba Diop, Veronique Leblond, Thomas Mercher, Jean-Baptiste Charbonnier, Rima Haddad
Publikováno v:
Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩
Cancer Discovery, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩
Cancer Discovery, American Association for Cancer Research, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩
Cancer Discovery, 2019, 9 (6), pp.796--811. ⟨10.1158/2159-8290.CD-18-0873⟩
The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA-binding sequences, and interaction with cofactors. They are regulated by extracellular clues and contribute to cellular processes, including proliferation
Autor:
Niki Stavroyianni, Helga D. Munch-Petersen, Kenichi Yoshida, Markus Schneider, Andreas Rosenwald, German Ott, Lucile Couronné, Michael Hummel, Marita Ziepert, Daniel Noerenberg, Emma Young, Richard Rosenquist, Seishi Ogawa, Thorsten Zenz, Jonathan C. Strefford, Larry Mansouri, Rose-Marie Amini, Hans G. Drexler, Viktor Ljungström, Martin-Leo Hansmann, Mareike Frick, Dido Lenze, Martin Erlanson, Ralf Küppers, Alfredo Rivas-Delgado, Armando López-Guillermo, Elisabeth Ralfkiaer, Christopher Maximilian Arends, Magnus Hultdin, Tatjana Pandzic, Bernd Dörken, Claudia D. Baldus, Maria K. Angelopoulou, Theodora Papadaki, Kirsten Grønbæk, Kostas Stamatopoulos, Anna Tasidou, Maysaa Abdulla, Nils Waldhueter, Frederik Damm, Theodoros P. Vassilakopoulos, Elias Campo, Damien Roos-Weil, Jude Fitzgibbon, Elena Mylonas, Blanca Gonzalez, Penelope Korkolopoulou, George Kanellis, Aron Skaftason, Gunilla Enblad, Olivier A. Bernard, Fazila Asmar, Jessica Okosun, Clemens A. Schmitt, Christian Bastard
Publikováno v:
Blood. 128:2666-2670
We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrati
Autor:
Oliver Bischof, Virginie Penard-Lacronique, Elena Mylonas, Cyril Quiveron, Michela Esposito, Laure Delestré, Christel Guillouf, Hengxiang Cui
Publikováno v:
Haematologica
Haematologica, 2017, 102 (11), pp.1850-1860. ⟨10.3324/haematol.2016.157636⟩
Haematologica, Ferrata Storti Foundation, 2017, 102 (11), pp.1850-1860. ⟨10.3324/haematol.2016.157636⟩
Haematologica, 2017, 102 (11), pp.1850-1860. ⟨10.3324/haematol.2016.157636⟩
Haematologica, Ferrata Storti Foundation, 2017, 102 (11), pp.1850-1860. ⟨10.3324/haematol.2016.157636⟩
International audience; Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679f36de03680a6acd05e0e5eeedd0ad
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234854
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234854
Autor:
Nils Waldhueter, Adrian Schreiber, Helga Fleischer-Notter, Tomasz Zemojtel, Sven Märdian, Mareike Frick, Kaja Hoyer, Marianne Sinn, Seishi Ogawa, Friederike Christen, Annegret Kunitz, Uwe Pelzer, Lars Bullinger, Frederik Damm, Ulrike Krüger, Kenichi Yoshida, Joel Galan-Sousa, Willy Chan, Daniel Noerenberg, Marten Jäger, Clemens A. Schmitt, Elena Mylonas, Bernd Dörken, Ricarda Seemann, Christopher Maximilian Arends
Publikováno v:
Leukemia. 32(9)
Clonal hematopoiesis of indeterminate potential (CHIP) occurs in an age-related manner and associates with an increased risk of hematologic cancer, atherosclerotic disease, and shorter overall survival. Little is known about the cell of origin, repar
Autor:
Shunqi Yan, Scott A. Biller, Fang Wang, David P. Schenkein, Marion Dorsch, Shinsan M. Su, Jeffrey O. Saunders, Jeremy Travins, Wentao Wei, Kimberly Straley, Wei Liu, Stefan Gross, Camelia Gliser, Lenny Dang, Elena Mylonas, Hua Yang, Sam Agresta, Erica Hansen, Véronique Saada, Stéphane de Botton, Byron DeLaBarre, Katharine E. Yen, Janeta Popovici-Muller, Stuart Murray, Erin Artin, Stefanie Schalm, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Yi Gao, Francesco G. Salituro
Publikováno v:
Science. 340:622-626
IDHology Among the most exciting drug targets to emerge from cancer genome sequencing projects are two related metabolic enzymes, isocitrate dehydrogenases 1 and 2 (IDH1, IDH2). Mutations in the IDH1 and IDH2 genes are common in certain types of huma