Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elena Meuser"'
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Pre- and Post-validation protein altering somatic variants identified by whole exome sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ce25dbcea6cfd110b3ebffd6c078d0
https://doi.org/10.1158/1078-0432.22468877.v1
https://doi.org/10.1158/1078-0432.22468877.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Purpose: Duodenal polyposis and cancer are important causes of morbidity and mortality in familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). This study aimed to comprehensively characterize somatic genetic changes in FAP and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bec1c9bec923fc598eec7d4581a8e81
https://doi.org/10.1158/1078-0432.c.6527084
https://doi.org/10.1158/1078-0432.c.6527084
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Summary of the 62 recurrently mutated genes in the exome dataset (supplementary table 2) and the number of mutations identified in each gene. Total numbers of variants in each gene take into account any mutations identified in duplicate adenomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62adb6221b5f63491470fe65c602c8d7
https://doi.org/10.1158/1078-0432.22468871.v1
https://doi.org/10.1158/1078-0432.22468871.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Database of somatic APC mutations reported in FAP and MAP duodenal and colorectal adenomas. NA, Not available. NI, Not identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020dd3dbf75d9991dcb718a7f0d1ca06
https://doi.org/10.1158/1078-0432.22468868.v1
https://doi.org/10.1158/1078-0432.22468868.v1
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Histogram showing number of validated protein changing somatic variants identified per adenoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1040802bee6a1a1ae545d716a6306af0
https://doi.org/10.1158/1078-0432.22468883
https://doi.org/10.1158/1078-0432.22468883
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64c8ab835872b933d4b632635faf610
https://doi.org/10.1158/1078-0432.22468880
https://doi.org/10.1158/1078-0432.22468880
Autor:
Julian R. Sampson, Susan K. Clark, Morgan Moorghen, Meleri Morgan, Geraint T. Williams, Sunil Dolwani, Sarah-Jane Walton, Meera Raja, Angharad Walters, Manon Harry, Helena Leon Brito, Julie Maynard, Shelley Idziaszczyk, Matthew Mort, Kevin E. Ashelford, Sian Jose, Elena Meuser, Joanna J. Hurley, Laura E. Thomas
Summary of all validated variants identified by exome sequencing. Patterned shading indicates duplicate adenomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc8eacbdb5e64c3d6861dab9e7d9f6
https://doi.org/10.1158/1078-0432.22468874
https://doi.org/10.1158/1078-0432.22468874
Autor:
Andrzej J. Rutkowski, J. Carl Barrett, Elizabeth A. Harrington, Elena Meuser, Vicky Rowlands, T. Hedley Carr
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Liquid biopsies offer the potential to monitor cancer response and resistance to therapeutics in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the fraction of circulating tumour DNA (ctDNA) bearing a mutation – lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc05b2bc4ddda9c7820f71f7c08574
http://link.springer.com/article/10.1038/s41598-019-49043-x
http://link.springer.com/article/10.1038/s41598-019-49043-x
Autor:
Laura E, Thomas, Joanna J, Hurley, Elena, Meuser, Sian, Jose, Kevin E, Ashelford, Matthew, Mort, Shelley, Idziaszczyk, Julie, Maynard, Helena Leon, Brito, Manon, Harry, Angharad, Walters, Meera, Raja, Sarah-Jane, Walton, Sunil, Dolwani, Geraint T, Williams, Meleri, Morgan, Morgan, Moorghen, Susan K, Clark, Julian R, Sampson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92e0485efbcf34e7db66e31f5a33faa0
https://pubmed.ncbi.nlm.nih.gov/28790112
https://pubmed.ncbi.nlm.nih.gov/28790112
Autor:
Jens Waak, Katharina Ross, Elena Meuser, Jörg Vollmer, Verena Arndt, Annette Friebe, Hanjo Hennemann, Carmen Schulten-Schulz, Daniel Friedrich, Franziska Agerer
Publikováno v:
Cancer Research. 75:2646-2646
Direct targeting of several important cancer pathways has so far proved challenging, owing to the lack of pathway-specific targets that can be accessed by conventional small molecule drugs or therapeutic antibodies. Nexigen develops and advances pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e04f751176fcbd96890383f18b45ca1
https://doi.org/10.1158/1538-7445.am2015-2646
https://doi.org/10.1158/1538-7445.am2015-2646