Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Elena Martinez-Terroba"'
Autor:
Kyle Begovich, Angela Schoolmeesters, Navin Rajapakse, Maneesh Kumar, Elena Martinez-Terroba, Arvind Shakya, Brandon Whitefield, Nataraj Pagadala, Aparajita Chourasia, Leah Fung
Publikováno v:
Molecular Cancer Research. 21:B002-B002
Although oncogenic Kirsten rat sarcoma virus (KRAS) was once deemed undruggable, recent advances have revealed promising anti-tumor effects with pan-KRAS and KRAS-mutant specific inhibitors in both preclinical and clinical settings. Despite the succe
Autor:
Kyle Begovich, Angela Schoolmeesters, Navin Rajapakse, Maneesh Kumar, Arvind Shakya, Brandon Whitefield, Elena Martinez-Terroba, Nataraj Pagadala, Shenlin Huang, Aparajita H. Chourasia, Leah Fung
Publikováno v:
Cancer Research. 83:1578-1578
KRAS, a GTPase that regulates cellular growth, is the most frequently mutated oncogene with implications in non-small cell lung, pancreatic and colorectal cancers. Hyperactivation of KRAS in mutant alleles favors KRAS in its active GTP-bound state ov
Autor:
Ivana Grbesa, María J Pajares, Elena Martínez-Terroba, Jackeline Agorreta, Ana-Matea Mikecin, Marta Larráyoz, Miguel A Idoate, Koraljka Gall-Troselj, Ruben Pio, Luis M Montuenga
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124670 (2015)
BACKGROUND:Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology. MATERIAL AND
Externí odkaz:
https://doaj.org/article/4a5e947f31154ebf86d37dc3155d1bc8