Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elena Martínez-Balsalobre"'
Autor:
Elena Martínez-Balsalobre, Jesús García-Castillo, Diana García-Moreno, Elena Naranjo-Sánchez, Miriam Fernández-Lajarín, María A. Blasco, Francisca Alcaraz-Pérez, Victoriano Mulero, María L. Cayuela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating myeloid gene expression. The CR4/CR5 domain of TERC is known to pl
Externí odkaz:
https://doaj.org/article/b9be5c1113344b78b8c5918c5e096611
Autor:
Lola Rodríguez‐Ruiz, Juan M Lozano‐Gil, Elena Naranjo‐Sánchez, Elena Martínez‐Balsalobre, Alicia Martínez‐López, Christophe Lachaud, Miguel Blanquer, Toan K Phung, Diana García‐Moreno, María L Cayuela, Sylwia D Tyrkalska, Ana B Pérez‐Oliva, Victoriano Mulero
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract Chronic inflammatory diseases are associated with hematopoietic lineage bias, including neutrophilia and anemia. We have recently identified that the canonical inflammasome mediates the cleavage of the master erythroid transcription factor G
Externí odkaz:
https://doaj.org/article/b205befa4d104117853060fc54fa807b
Autor:
Manuel Bernabé‐García, Elena Martínez‐Balsalobre, Diana García‐Moreno, Jesús García‐Castillo, Beatriz Revilla‐Nuin, Elena Blanco‐Alcaina, Victoriano Mulero, Francisca Alcaraz‐Pérez, María L. Cayuela
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described. In this study, we report that
Externí odkaz:
https://doaj.org/article/310687909ba642c2bc2405940c482ed2
Autor:
Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C. Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Fresquet, Jose A. Martínez-Climent, Maria C. Mateos, Maria L. Cayuela, Goutham Narla, Maria D. Odero, Carmen Vicente
Publikováno v:
Blood. 141:1047-1059
Venetoclax combination therapies are becoming the standard of care in acute myeloid leukemia (AML). However, the therapeutic benefit of these drugs in older/unfit patients is limited to only a few months, highlighting the need for more effective ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bad8f40671cd9ecfae213074da16a6
https://doi.org/10.1182/blood.2022016466
https://doi.org/10.1182/blood.2022016466
Autor:
Elena Martínez-Balsalobre, Jean-Hugues Guervilly, Jenny van Asbeck-van der Wijst, Ana Belén Pérez-Oliva, Christophe Lachaud
Publikováno v:
Blood Reviews. :101094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e2f4d73adc05daae0e6598a388b62e0
https://doi.org/10.1016/j.blre.2023.101094
https://doi.org/10.1016/j.blre.2023.101094
Autor:
Nerea Marcotegui, Patricia García-Ramírez, María C. Mateos, Elena Martínez-Balsalobre, María D. Odero, Irene Peris, Elizabeth Guruceaga, María L. Cayuela, Obdulia Rabal, Julen Oyarzabal, Carmen Vicente, Felipe Prosper, Raffaella Pippa, Elena Arriazu
Publikováno v:
Cancer Letters. 468:1-13
Acute myeloid leukemia (AML) is an aggressive disease associated with very poor prognosis. Most patients are older than 60 years, and in this group only 5–15% of cases survive over 5 years. Therefore, it is urgent to develop more effective targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156028d944698f71baf66b6b950c95a
https://doi.org/10.1016/j.canlet.2019.10.007
https://doi.org/10.1016/j.canlet.2019.10.007
Autor:
Irene Peris, Raffaella Pippa, Patricia García-Ramírez, María C. Mateos, Nerea Marcotegui, Ana Igea, Diego Alignani, María D. Odero, Elena Martínez-Balsalobre, Elena Arriazu, Angel R. Nebreda, María L. Cayuela, José Rifón, Carmen Vicente
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 1, Pp 1-15 (2020)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Blood Cancer Journal
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Blood Cancer Journal
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy. Although novel emerging drugs are available, the overall prognosis remains poor and new therapeutic approaches are required. PP2A phosphatase is a key regulator of cell homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da6c284b7d02db41d143782403d1a6
http://link.springer.com/article/10.1038/s41408-019-0270-0
http://link.springer.com/article/10.1038/s41408-019-0270-0
Autor:
Jesús García-Castillo, Victoriano Mulero, Francisca Alcaraz-Pérez, Elena Martínez-Balsalobre, David Hernández-Silva, Monique Anchelin-Flageul, Maria Caterina Mione, María L. Cayuela
Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical to organ homeostasis. Zebrafish has become a useful vertebrate model for understanding the cellular and molecular mechanisms of regeneration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df202dc6c7dc85ad390764347f4feeae
https://doi.org/10.1101/2021.11.15.468592
https://doi.org/10.1101/2021.11.15.468592
Autor:
Virginia C Rodriguez-Cortez, Francisca Alcaraz-Pérez, Leonard I. Zon, Isaac Adatto, Miriam Fernandez-Lajarín, Diana García-Moreno, Victoriano Mulero, María L. Cayuela, Suneet Agarwal, Clara Bueno, Manuel Bernabé-García, Elena Martínez-Balsalobre, Marlies P. Rossmann, Ana B. Pérez-Oliva, Pablo Menendez, Jesús García-Castillo
Publikováno v:
Proc Natl Acad Sci U S A
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that zebrafish telomerase RNA (terc) binds to specific DNA sequences of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a1cfeed783a66cdec2bd5950a55f25
https://doi.org/10.1073/pnas.2015528118
https://doi.org/10.1073/pnas.2015528118
Autor:
Francisca Alcaraz-Pérez, Victoriano Mulero, Elena Blanco-Alcaina, Jesús García-Castillo, Manuel Bernabé-García, Elena Martínez-Balsalobre, Beatriz Revilla-Nuin, Diana García-Moreno, María L. Cayuela
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Molecular Oncology, Vol 15, Iss 7, Pp 1818-1834 (2021)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described. In this study, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb69f40644c2c6c170f6fd286a61eb1
https://doi.org/10.1002/1878-0261.12943
https://doi.org/10.1002/1878-0261.12943