Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Elena Mariotto"'
Autor:
Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Ilaria Zeni, Lorenzo Manfreda, Chiara Marchioro, Martina Canton, Alice Cani, Ruben Magni, Alessandra Luchini, Silvia Bresolin, Giampietro Viola, Luca Persano
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Chemotherapy resistance is considered one of the main causes of tumor relapse, still challenging researchers for the identification of the molecular mechanisms sustaining its emergence. Here, we setup and characterized chemotherapy-resistant
Externí odkaz:
https://doaj.org/article/72f58709d4e748608303fe94f6b17b4c
Autor:
Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, Romeo Romagnoli
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7519 (2024)
Because of synergism between tubulin and HDAC inhibitors, we used the pharmacophore fusion strategy to generate potential tubulin–HDAC dual inhibitors. Drug design was based on the introduction of a N-hydroxyacrylamide or a N-hydroxypropiolamide at
Externí odkaz:
https://doaj.org/article/1e5ac161f11043a0953566f7f8829ff5
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
Autor:
Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini, Sanja Aveic
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract Background Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have notable long-term ef
Externí odkaz:
https://doaj.org/article/3544c2c213fe41539b897649ac845d8c
Autor:
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Lorenzo Manfreda, Elena Mariotto, Roberta Bortolozzi, Giampietro Viola
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1031 (2022)
A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3′,4′,5′-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine pharmacophor
Externí odkaz:
https://doaj.org/article/cc07dc069850450cb83a094b4295b925
Autor:
Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Noemi Milan, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1191 (2022)
Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (7a–ad) and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-a]pyrimidine nucleus, had moderate to potent antip
Externí odkaz:
https://doaj.org/article/d51587f8f4754b5eb51cf08ab0edb9d3
Autor:
Elena Rampazzo, Lorenzo Manfreda, Silvia Bresolin, Alice Cani, Elena Mariotto, Roberta Bortolozzi, Alessandro Della Puppa, Giampietro Viola, Luca Persano
Publikováno v:
Cancers, Vol 14, Iss 8, p 1897 (2022)
Despite being subjected to high-dose chemo and radiotherapy, glioblastoma (GBM) patients still encounter almost inevitable relapse, due to the capability of tumor cells to disseminate and invade normal brain tissues. Moreover, the presence of a cance
Externí odkaz:
https://doaj.org/article/14cfd0b08aad45b7aaa9993d3afc00e7
Autor:
Pilar María Luque-Navarro, Elena Mariotto, Marco Ballarotto, Gianluca Rubbini, Francisco José Aguilar-Troyano, Alberto Fasiolo, Archimede Torretta, Emilio Parisini, Antonio Macchiarulo, Alejandro Laso, Carmen Marco, Giampietro Viola, María Paz Carrasco-Jimenez, Luisa Carlota López-Cara
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 715 (2022)
Due to its role in lipid biosynthesis, choline kinase α1 (CKα1) is an interesting target for the development of new antitumor agents. In this work, we present a series of 41 compounds designed based on the well-known and successful strategy of intr
Externí odkaz:
https://doaj.org/article/122063277df142bd9892a85aa125ed4d
Autor:
Santiago Schiaffino-Ortega, Elena Mariotto, Pilar María Luque-Navarro, María Kimatrai-Salvador, Pablo Rios-Marco, Ramon Hurtado-Guerrero, Carmen Marco, María Paz Carrasco-Jimenez, Giampietro Viola, Luisa Carlota López-Cara
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1360 (2021)
Choline kinase inhibitors are an outstanding class of cytotoxic compounds useful for the treatment of different forms of cancer since aberrant choline metabolism is a feature of neoplastic cells. Here, we present the most in-depth structure-activity
Externí odkaz:
https://doaj.org/article/bd84aa4beeae4625a0949687619ee237
Autor:
Muhammad Altaf, Naike Casagrande, Elena Mariotto, Nadeem Baig, Abdel-Nasser Kawde, Giuseppe Corona, Roberto Larcher, Cinzia Borghese, Claudia Pavan, Adam A. Seliman, Donatella Aldinucci, Anvarhusein A. Isab
Publikováno v:
Cancers, Vol 11, Iss 4, p 474 (2019)
We synthesized eight new bipyridine and bipyrimidine gold (III) dithiocarbamate-containing complexes (C1–C8) and tested them in a panel of human cancer cell lines. We used osteosarcoma (MG-63), lung (A549), prostate (PC3 and DU145), breast (MCF-7),
Externí odkaz:
https://doaj.org/article/47901cc90fda4dd59e7825faa6c65df1
Autor:
Elena Mariotto, Giampietro Viola, Roberto Ronca, Luca Persano, Sanja Aveic, Zaver M. Bhujwalla, Noriko Mori, Benedetta Accordi, Valentina Serafin, Luisa Carlota López-Cara, Roberta Bortolozzi
Publikováno v:
Cancers, Vol 10, Iss 10, p 391 (2018)
Choline kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes. EB-3D is a novel choline kinase α1 (ChoKα1) inhibitor with po
Externí odkaz:
https://doaj.org/article/44890f4011ce44298a1a863549149341