Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

Autor: Giovanna Sociali, Davide Visigalli, Thomas Prukop, Ilaria Cervellini, Elena Mannino, Consuelo Venturi, Santina Bruzzone, Michael W. Sereda, Angelo Schenone

Publikováno v: Neurobiology of Disease, Vol 95, Iss , Pp 145-157 (2016)

Charcot-Marie-Tooth 1A (CMT1A) is a demyelinating hereditary neuropathy for which pharmacological treatments are not yet available. An abnormally high intracellular Ca2+ concentration was observed in Schwann cells (SC) from CMT1A rats, caused by the

Externí odkaz: https://doaj.org/article/e0b812583bae437a95e6d60c5edf1094

Impaired increase of plasma abscisic Acid in response to oral glucose load in type 2 diabetes and in gestational diabetes.

Autor: Pietro Ameri, Santina Bruzzone, Elena Mannino, Giovanna Sociali, Gabriella Andraghetti, Annalisa Salis, Monica Laura Ponta, Lucia Briatore, Giovanni F Adami, Antonella Ferraiolo, Pier Luigi Venturini, Davide Maggi, Renzo Cordera, Giovanni Murialdo, Elena Zocchi

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0115992 (2015)

The plant hormone abscisic acid (ABA) is present and active in humans, regulating glucose homeostasis. In normal glucose tolerant (NGT) human subjects, plasma ABA (ABAp) increases 5-fold after an oral glucose load. The aim of this study was to assess

Externí odkaz: https://doaj.org/article/99205e2a5d3a477fb749192e1ddc5ab4

Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

Autor: Laura Sturla 1, Elena Mannino 1, Sonia Scarfì 2, Santina Bruzzone 1, Mirko Magnone 1, Giovanna Sociali 1, Valeria Booz 2, Lucrezia Guida 1, Tiziana Vigliarolo 1, Chiara Fresia 1, Laura Emionite 3, Ambra Buschiazzo 4, Cecilia Marini 5, 6, Gianmario Sambuceti 4, Antonio De Flora 1, Elena Zocchi 2

Publikováno v: Biochimica and biophysica acta. Molecular and cell biology of lipids 1862 (2017): 131–144. doi:10.1016/j.bbalip.2016.11.005
info:cnr-pdr/source/autori:Laura Sturla 1, Elena Mannino 1, Sonia Scarfì 2, Santina Bruzzone 1, Mirko Magnone 1, Giovanna Sociali 1, Valeria Booz 2, Lucrezia Guida 1, Tiziana Vigliarolo 1, Chiara Fresia 1, Laura Emionite 3, Ambra Buschiazzo 4, Cecilia Marini 5,6, Gianmario Sambuceti 4,6, Antonio De Flora 1, Elena Zocchi 2/titolo:Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo./doi:10.1016%2Fj.bbalip.2016.11.005/rivista:Biochimica and biophysica acta. Molecular and cell biology of lipids/anno:2017/pagina_da:131/pagina_a:144/intervallo_pagine:131–144/volume:1862

Abscisic acid (ABA) is a plant hormone also present in animals, where it is involved in the regulation of innate immune cell function and of glucose disposal, through its receptor LANCL2. ABA stimulates glucose uptake by myocytes and pre-adipocytes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f62e02912eb659d08518eae71aefff1

The Diadenosine Homodinucleotide P18 Improves In Vitro Myelination in Experimental Charcot‐Marie‐Tooth Type 1A

Autor: Fulvia Fiorese, Lucilla Nobbio, Antonio De Flora, Angelo Schenone, Matthias U. Kassack, Laura Sturla, Santina Bruzzone, Elena Zocchi, Elena Mannino, Valeria Prada, Davide Visigalli

Publikováno v: Journal of Cellular Biochemistry. 115:161-167

Charcot-Marie-Tooth 1A (CMT1A) is a demyelinating hereditary neuropathy whose pathogenetic mechanisms are still poorly defined and an etiologic treatment is not yet available. An abnormally high intracellular Ca(2+) concentration ([Ca(2+)]i) occurs i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033ec641de435cae3e24b078ee3568a1
https://doi.org/10.1002/jcb.24644

Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats

Autor: Antonio De Flora, Chiara Fresia, Santina Bruzzone, Laura Sturla, Mirko Magnone, Giovanna Sociali, Laura Emionite, Elena Mannino, Elena Zocchi, Valeria Booz

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140588 (2015)
PLoS ONE

In recent years, Abscisic Acid (ABA) has been demonstrated to be involved in the regulation of glucose homeostasis in mammals as an endogenous hormone, by stimulating both insulin release and peripheral glucose uptake. In addition, ABA is released by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af25d41315c49ad79b3e8f9d1205658
http://europepmc.org/articles/PMC4619318?pdf=render