Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elena M. Drummond"'
Autor:
Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman
Publikováno v:
Journal of Medicinal Chemistry. 55:9240-9254
The cognitive impairments observed in Alzheimer’s disease (AD) are in part a consequence of reduced acetylcholine (ACh) levels resulting from a loss of cholinergic neurons. Preclinically, serotonin 4 receptor (5-HT4) agonists are reported to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d51b0b91e9707931c753f01d83b2c9f
https://doi.org/10.1021/jm300953p
https://doi.org/10.1021/jm300953p
Autor:
Gregory W Cadelina, Catherine D Pilsmaker, Sharon Carmel, Robin J. Kleiman, Jo Ann Dumin, Abigail Mariga, Wendy O. Adamowicz, Elena M. Drummond, Thomas A. Lanz, Brentt J Swetter, Susan E. Bove
Publikováno v:
Biomarkers. 17:524-531
Adult rats were treated acutely with peripheral kainic acid (KA), and changes in brain-derived neurotrophic factor (BDNF) mRNA and protein were tracked over time across multiple brain regions. Despite robust elevation in both mRNA and protein in mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a8776a0782dde56fce76b4b674adeb
https://doi.org/10.3109/1354750x.2012.694476
https://doi.org/10.3109/1354750x.2012.694476
Autor:
Karen Elaine Sexton, Venkataraman Thanabal, Ann McCarthy, Leroy Lu, Erli Zhang, Maria N. Nguyen, Downs Victoria Leigh, Paul R. Keller, Mark L. Boys, Richard Gowan, Patrick I. McConnell, Edmund L. Ellsworth, Neil Raheja, Richard B. Gilbertsen, Hena Mostafa, Filzen Gary Frederick, N. A. Payne, Feng Bian, Huifen Chen, John D. Knafels, Samarendra N. Maiti, Elena M. Drummond, Stephen Douglas Barrett, Zhi Wang, Larry D. Bratton, Diane Alessi, Deepak S. Lala, Stephen Fakhoury, Sneha Patel, Barry C. Finzel, Susan Ciotti, Iula Donna Michele, Fang Sun, Paul Angell, Xiao Dan Ren, David Pocalyko, Rone Eisma, Kramer James Bernard, Catherine R. Kostlan, Christopher L. Chio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3392-3397
A series of 2-(1H-pyrazol-1-yl)pyridines are described as inhibitors of ALK5 (TGFβ receptor I kinase). Modeling compounds in the ALK5 kinase domain enabled some optimization of potency via substitutions on the pyrazole core. One of these compounds P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632fe42ba8bb00febbc77151eb92bc8f
https://doi.org/10.1016/j.bmcl.2012.04.013
https://doi.org/10.1016/j.bmcl.2012.04.013
Autor:
Jie Jack Li, Lain-Yen Hu, Mark Lovdahl, Daniel Y. Du, Brian Samas, Iula Donna Michele, Mark L. Boys, Garrett S. Hoge, Elena M. Drummond, Matthew Carroll, Danielle Dettling, William Glen Harter, Veerabahu Shanmugasundaram, Jeffrey Asbill, Maria N. Nguyen, Theresa Krieger-Burke, Wen-Song Yue, Bruce Allen Lefker, Susan Ciotti, Kimberly Jane Wade, Zhi Wang, Theodore R. Johnson, Jennifer A. Van Camp, Mary Ann Meade
Publikováno v:
Journal of Medicinal Chemistry. 51:7010-7014
4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd56ef08bd905300c38ac78afc3cbfd
https://doi.org/10.1021/jm8009316
https://doi.org/10.1021/jm8009316
Autor:
Anabella Villalobos, Sarah Grimwood, Lei Zhang, Michelle Vanase-Frawley, Michael Aaron Brodney, Elena M. Drummond, Julie Cianfrogna, Susan E. Drozda
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(22)
Herein we report the identification of (+)- N -(2-((1 H -pyrazol-1-yl)methyl)-3-((1 R ,3 r ,5 S )-6′-fluoro-8-azaspiro[bicyclo[3.2.1]octane-3,1′-isochroman]-8-yl)propyl)- N -[ 3 H ]-methylacetamide {[ 3 H]PF-7191 [(+)- 11 ]} as a promising radiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c03cd4714188952e65a923d181263
https://pubmed.ncbi.nlm.nih.gov/25442316
https://pubmed.ncbi.nlm.nih.gov/25442316
Autor:
Michael A, Brodney, David E, Johnson, Aarti, Sawant-Basak, Karen J, Coffman, Elena M, Drummond, Emily L, Hudson, Katherine E, Fisher, Hirohide, Noguchi, Nobuaki, Waizumi, Laura L, McDowell, Alexandros, Papanikolaou, Betty A, Pettersen, Anne W, Schmidt, Elaine, Tseng, Kim, Stutzman-Engwall, David M, Rubitski, Michelle A, Vanase-Frawley, Sarah, Grimwood
Publikováno v:
Journal of medicinal chemistry. 55(21)
The cognitive impairments observed in Alzheimer's disease (AD) are in part a consequence of reduced acetylcholine (ACh) levels resulting from a loss of cholinergic neurons. Preclinically, serotonin 4 receptor (5-HT(4)) agonists are reported to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::992b76c5d59721c47b0dcac97b51e486
https://pubmed.ncbi.nlm.nih.gov/22974325
https://pubmed.ncbi.nlm.nih.gov/22974325
Autor:
Aarti Sawant-Basak, Emily Miller, Michelle Vanase-Frawley, Mihály Hajós, Laura McDowell, David M. Rubitski, Kim Jonelle Stutzman-Engwall, Roxanne R Gorczyca, Weldon Horner, Katherine Fisher, Elaine E. Tseng, David E. Johnson, Sarah Grimwood, Elena M. Drummond, Chester J. Siok, Robin T. Nelson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 341(3)
5-Hydroxytryptamine (5-HT)(4) receptor agonists reportedly stimulate brain acetylcholine (ACh) release, a property that might provide a new pharmacological approach for treating cognitive deficits associated with Alzheimer's disease. The purpose of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004fc131fe86d44da7998100426a1d2
https://pubmed.ncbi.nlm.nih.gov/22408061
https://pubmed.ncbi.nlm.nih.gov/22408061
Autor:
Ken Zasadny, Claire Leurent, Emily Miller, Carolyn Rowinski, Michael Aaron Brodney, Evan D. Morris, Karen J. Coffman, Adam Ogden, Beata Planeta-Wilson, Richard E. Carson, David Raunig, Marc B. Skaddan, Yi Wang, Tracey L. Rapp, Sarah Grimwood, Timothy Nicholas, Jim Ropchan, Yo-sub Park, Yu-Shin Ding, Elyse Katz, Sridhar Duvvuri, Elena M. Drummond, Aarti Sawant
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d0acfea9b6776cccd7e03713ed0bfc
https://doi.org/10.1016/j.jalz.2011.05.1875
https://doi.org/10.1016/j.jalz.2011.05.1875
Autor:
Longfei Xie, Elena M. Drummond, Brian M. Campbell, Gary Bora, Christopher J. O’Donnell, Tammy Whisman, Nancy C. Stratman, Al Probert, Amy B. Dounay, Martin Pettersson, Kim Zoski, David Gray
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(2)
Compounds with combined norepinephrine reuptake inhibitor (NRI) and serotonin 1A (5-HT(1A)) partial agonist pharmacology may offer a new therapeutic approach for treating symptoms of neuropsychiatric disorders including ADHD, depression, and anxiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d341c6ea5766d52e25cc6defc3fd251
https://pubmed.ncbi.nlm.nih.gov/21185183
https://pubmed.ncbi.nlm.nih.gov/21185183