Výsledky vyhledávání - "Elena M Pugacheva"

Akademický článek

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites

Autor: Elena M. Pugacheva, Dharmendra Nath Bhatt, Samuel Rivero-Hinojosa, Md Tajmul, Liron Fedida, Emma Price, Yon Ji, Dmitri Loukinov, Alexander V. Strunnikov, Bing Ren, Victor V. Lobanenkov

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-40 (2024)

Abstract Background Pervasive usage of alternative promoters leads to the deregulation of gene expression in carcinogenesis and may drive the emergence of new genes in spermatogenesis. However, little is known regarding the mechanisms underpinning th

Externí odkaz: https://doaj.org/article/7545d2268ffe4ce8b98c890ee6a96563

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Akademický článek

The structural complexity of the human BORIS gene in gametogenesis and cancer.

Autor: Elena M Pugacheva, Teruhiko Suzuki, Svetlana D Pack, Natsuki Kosaka-Suzuki, Jeongheon Yoon, Alexander A Vostrov, Eugene Barsov, Alexander V Strunnikov, Herbert C Morse, Dmitri Loukinov, Victor Lobanenkov

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13872 (2010)

BORIS/CTCFL is a paralogue of CTCF, the major epigenetic regulator of vertebrate genomes. BORIS is normally expressed only in germ cells but is aberrantly activated in numerous cancers. While recent studies demonstrated that BORIS is a transcriptiona

Externí odkaz: https://doaj.org/article/ea03c98b6d9b4c789955d56d6cf365ec

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Akademický článek

An updated catalog of CTCF variants associated with neurodevelopmental disorder phenotypes

Autor: Emma Price, Liron M. Fedida, Elena M. Pugacheva, Yon J. Ji, Dmitri Loukinov, Victor V. Lobanenkov

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

IntroductionCTCF-related disorder (CRD) is a neurodevelopmental disorder (NDD) caused by monoallelic pathogenic variants in CTCF. The first CTCF variants in CRD cases were documented in 2013. To date, 76 CTCF variants have been further described in t

Externí odkaz: https://doaj.org/article/824711df00be4707b31274bf5f351af9

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Akademický článek

The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

Autor: Samuel Rivero-Hinojosa, Elena M. Pugacheva, Sungyun Kang, Claudia Fabiola Méndez-Catalá, Alexander L. Kovalchuk, Alexander V. Strunnikov, Dmitri Loukinov, Jeannie T. Lee, Victor V. Lobanenkov

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male

Externí odkaz: https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded84

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