Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elena Loiko"'
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants. METHODS We examined associ
Externí odkaz:
https://doaj.org/article/f942fc4def444aaf801aad1a51aec5af
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The APOE ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We examined whether these alleles modulated associations of 94 single-nucleotide polymorphisms (SNPs) harbored by 26 genes in 19q13.3 region with 217 plasma
Externí odkaz:
https://doaj.org/article/d9da6cdfd31e4a59a52ac8077b1b005f
Autor:
Liang He, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, Matt Duan, Arseniy Yashkin, Svetlana V. Ukraintseva, Mikhail Kovtun, Anatoliy I. Yashin, Alexander M. Kulminski
Publikováno v:
Frontiers in Genetics, Vol 8 (2018)
Externí odkaz:
https://doaj.org/article/8ffe8792af664030a54c65b7a2d41c50
Autor:
Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu, Anatoliy I Yashin
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006314 (2016)
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene stu
Externí odkaz:
https://doaj.org/article/4119000c967b4da88792985d10b82e1a
Autor:
Liang He, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, Matt Duan, Arseniy Yashkin, Svetlana V. Ukraintseva, Mikhail Kovtun, Anatoliy I. Yashin, Alexander M. Kulminski
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Age-related diseases may result from shared biological mechanisms in intrinsic processes of aging. Genetic effects on age-related diseases are often modulated by environmental factors due to their little contribution to fitness or are mediated throug
Externí odkaz:
https://doaj.org/article/4592b2d26cfd4542aad0a22f5bb1ddb6
Autor:
Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, Alexander M. Kulminski
Publikováno v:
Aging. 15:3249-3272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7da835e1e1a97522038f861a6b5482d
https://doi.org/10.18632/aging.204665
https://doi.org/10.18632/aging.204665
Publikováno v:
GeroScience
Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e9d937f1d3ac41d117807423aa20b
http://europepmc.org/articles/PMC8572080
http://europepmc.org/articles/PMC8572080
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Publikováno v:
Aging Cell. 21
Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0ff7575b94bde4803356c88af5bd2b
https://doi.org/10.1111/acel.13730
https://doi.org/10.1111/acel.13730
Publikováno v:
GeroScience
The APOE ε2/ε3/ε4 polymorphism is associated with multiple non-Mendelian traits, including high- (HDL-C) and low- (LDL-C) density lipoprotein cholesterol, triglycerides, body mass index (BMI), coronary heart disease (CHD), and Alzheimer’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7d6da6da8a4cacba04d8f475ed350c
https://doi.org/10.1007/s11357-021-00458-3
https://doi.org/10.1007/s11357-021-00458-3
Autor:
Alexander M, Kulminski, Ethan, Jain-Washburn, Elena, Loiko, Yury, Loika, Fan, Feng, Irina, Culminskaya
Publikováno v:
Aging. 14
Capturing the genetic architecture of Alzheimer's disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. It has been suggested that AD biomarkers may improve the characterization of AD patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce7efcea82e007e4425aadc8c7c19ce9
https://pubmed.ncbi.nlm.nih.gov/36399096
https://pubmed.ncbi.nlm.nih.gov/36399096