Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Elena Lastochkin"'
Autor:
Martín Alcorlo, David A. Dik, Stefania De Benedetti, Kiran V. Mahasenan, Mijoon Lee, Teresa Domínguez-Gil, Dusan Hesek, Elena Lastochkin, Daniel López, Bill Boggess, Shahriar Mobashery, Juan A. Hermoso
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
SPOR domains are present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. Here, Alcorlo et al. show that, indeed, the presence of peptide stems abrogates binding to a SPOR domain, and provide insight
Externí odkaz:
https://doaj.org/article/120e67d6e4b84738995cb033a43e838a
Autor:
Mijoon Lee, Shahriar Mobashery, Dusan Hesek, Focco van den Akker, Jacob Boorman, Elena Lastochkin, Ximin Zeng, Jun Lin, Snigdha A. Mathure, Vijay Kumar
Publikováno v:
Biochemistry. 60:1133-1144
The soluble lytic transglycosylase Cj0843c from Campylobacter jejuni breaks down cell-wall peptidoglycan (PG). Its nonhydrolytic activity sustains cell-wall remodeling and repair. We report herein our structure-function studies probing the substrate
Autor:
Mayland Chang, Enrico Speri, Valerie A. Schroeder, Elena Lastochkin, Cesar Masitas, Jeshina Janardhanan, Shahriar Mobashery, William R. Wolter, Jed F. Fisher
Publikováno v:
ACS Infectious Diseases. 6:2362-2368
A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibioti
Autor:
Kiran V. Mahasenan, Jeshina Janardhanan, Sara Tejera, Elena Lastochkin, Shahriar Mobashery, Yuanyuan Qian, William R. Wolter, Giuseppe Allegretta, Zhihong Peng, Melissa Malia N. Gozun, Mayland Chang, Rhona Feltzer, Valerie A. Schroeder
Publikováno v:
Journal of Medicinal Chemistry. 63:5287-5296
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure-activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. Sub
Autor:
Daniel Lopez, Martín Alcorlo, Elena Lastochkin, Teresa Domínguez-Gil, Kiran V. Mahasenan, David A. Dik, Bill Boggess, Mijoon Lee, Shahriar Mobashery, Dusan Hesek, Stefania De Benedetti, Juan A. Hermoso
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
13 pags., 9 figs. -- Open Access funded by Creative Commons Atribution Licence 4.0
SPOR domains are widely present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. This type of peptidoglycan is
SPOR domains are widely present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. This type of peptidoglycan is
Autor:
Mayland Chang, Enrico Speri, Allen G. Oliver, Elena Lastochkin, Man Wang, Jed F. Fisher, Jeshina Janardhanan, Stefania De Benedetti, Yuanyuan Qian, Shahriar Mobashery, Cesar Masitas, Valerie A. Schroeder, William R. Wolter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55082532619fb3ef047df3b2e1cb42df
https://europepmc.org/articles/PMC8201750/
https://europepmc.org/articles/PMC8201750/
Autor:
Shahriar Mobashery, Choon Kim, Yuanyuan Qian, Enrico Speri, Elena Lastochkin, Jed F. Fisher, Stefania De Benedetti, Jennifer Fishovitz
Publikováno v:
ACS Med Chem Lett
[Image: see text] β-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that resto
Autor:
Shahriar Mobashery, Jed F. Fisher, William C. Boggess, Elena Lastochkin, David A. Dik, Joshua D. Shrout, Shusuke Tomoshige, Choonkeun Kim, Chinedu S. Madukoma
Publikováno v:
ACS Chem Biol
The interplay between the activities of lytic transglycosylases (LTs) and penicillin-binding proteins (PBPs) is critical for the health of bacterial cell wall. Bulgecin A (a natural-product inhibitor of LTs) potentiates the activity of β-lactam anti
Autor:
Vijay, Kumar, Snigdha A, Mathure, Mijoon, Lee, Jacob, Boorman, Ximin, Zeng, Jun, Lin, Dusan, Hesek, Elena, Lastochkin, Shahriar, Mobashery, Focco, van den Akker
Publikováno v:
Biochemistry
The soluble lytic transglycosylase Cj0843c from Campylobacter jejuni breaks down cell-wall peptidoglycan (PG). Its non-hydrolytic activity sustains cell-wall remodeling and repair. We report herein our structure-function studies probing the substrate
Autor:
Enrico, Speri, Jeshina, Janardhanan, Cesar, Masitas, Valerie A, Schroeder, Elena, Lastochkin, William R, Wolter, Jed F, Fisher, Shahriar, Mobashery, Mayland, Chang
Publikováno v:
ACS Infect Dis
A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-positive bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibioti