Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elena L. Pobezinskaya"'
Autor:
Alexandria C. Wells, Kaito A. Hioki, Constance C. Angelou, Adam C. Lynch, Xueting Liang, Daniel J. Ryan, Iris Thesmar, Saule Zhanybekova, Saulius Zuklys, Jacob Ullom, Agnes Cheong, Jesse Mager, Georg A. Hollander, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of the CD8 T cell-mediated immune response against infections and tumors depends on the formation of a long-lived memory pool, and the protection of effector cells from exhaustion. The advent of checkpoint blockade therapy has si
Externí odkaz:
https://doaj.org/article/91894239e4cb479a9f76d823674243ce
Autor:
Kaito A. Hioki, Daniel J. Ryan, Iris Thesmar, Adam C. Lynch, Leonid A. Pobezinsky, Elena L. Pobezinskaya
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The phenomenon of intercellular transfer of cellular material, including membranes, cytoplasm, and even organelles, has been observed for decades. The functional impact and molecular mechanisms of such transfer in the immune system remain largely elu
Externí odkaz:
https://doaj.org/article/a8da7881315c4b56b8e0abab54cb6f54
Autor:
Constance C. Angelou, Alexandria C. Wells, Jyothi Vijayaraghavan, Carey E. Dougan, Rebecca Lawlor, Elizabeth Iverson, Vanja Lazarevic, Motoko Y. Kimura, Shelly R. Peyton, Lisa M. Minter, Barbara A. Osborne, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 path
Externí odkaz:
https://doaj.org/article/a7dd3d5c2ffa4be3b33d686e3be2cc19
Autor:
Elena L. Pobezinskaya, Alexandria C. Wells, Constance C. Angelou, Eric Fagerberg, Esengul Aral, Elizabeth Iverson, Motoko Y. Kimura, Leonid A. Pobezinsky
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Maintaining the diversity and constant numbers of naïve T cells throughout the organism's lifetime is necessary for efficient immune responses. Naïve T cell homeostasis, which consists of prolonged survival, occasional proliferation and enforcement
Externí odkaz:
https://doaj.org/article/aa61e98640f946c59d31e46222931eff
Autor:
Deeksha Mohan, Heather L. Sherman, Ankita Mitra, Rebecca Lawlor, Sudarvili Shanthalingam, Jacob Ullom, Elena L. Pobezinskaya, Guodong Zhang, Barbara A. Osborne, Leonid A. Pobezinsky, Gregory N. Tew, Lisa M. Minter
Publikováno v:
Molecular Immunology. 157:129-141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8dc9e1154bbba7bc33e1907f9d6798
https://doi.org/10.1016/j.molimm.2023.03.020
https://doi.org/10.1016/j.molimm.2023.03.020
Publikováno v:
Mol Immunol
CD8 T cells are among the most vigorous soldiers of the immune system that fight viral infections and cancer. CD8 T cell development, maintenance, activation and differentiation are under the tight control of multiple transcriptional and post-transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89417195fe8c689d20c224c4ee667c8
https://doi.org/10.1016/j.molimm.2020.01.023
https://doi.org/10.1016/j.molimm.2020.01.023
Autor:
Shelly R. Peyton, Constance C Angelou, Rebecca G. Lawlor, Elizabeth Iverson, Lisa M. Minter, Leonid A. Pobezinsky, Jyothi Vijayaraghavan, Carey E. Dougan, Barbara A. Osborne, Vanja Lazarevic, Motoko Y. Kimura, Alexandria C Wells, Elena L Pobezinskaya
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Frontiers in Immunology
Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57195c5dff171925719f7baa9d31e133
https://doi.org/10.3389/fimmu.2019.03125
https://doi.org/10.3389/fimmu.2019.03125
Autor:
Constance C Angelou, Alexandria C Wells, Jyothi Vijayarhagavan, Carey E Dougan, Rebecca Lawlor, Elizabeth Iverson, Vanja Lazarevic, Motoko Y Kimura, Shelly R Peyton, Lisa M Minter, Barbara A Osborne, Elena L Pobezinskaya, Leonid A Pobezinsky
Publikováno v:
The Journal of Immunology. 204:76.11-76.11
Autoimmune disorders such as multiple sclerosis (MS) are caused by proinflammatory events mediated by pathogenic Th17 cells. In MS, these cells arise in response to autoantigen recognition and exposure to the cytokines IL-1β and IL-23, migrate to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172d6978f4f9b0334c7270ff7385b07a
https://doi.org/10.4049/jimmunol.204.supp.76.11
https://doi.org/10.4049/jimmunol.204.supp.76.11
Autor:
Alexandria C Wells, Michele Markstein, Eric Fagerberg, Raymond M. Welsh, Amy S. Burnside, Keith A. Daniels, Leonid A. Pobezinsky, Constance C Angelou, Elena L Pobezinskaya, Dominique Alfandari
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses. Here, using a mouse model, we describe a dual role for the let-7 microRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab46f7ac028b563f18316c0afb0d9497
https://doi.org/10.7554/elife.26398
https://doi.org/10.7554/elife.26398
Autor:
Raymond M. Welsh, Elena L Pobezinskaya, Amy S. Burnside, Michele Markstein, Keith A. Daniels, Alexandria C Wells, Eric Fagerberg, Dominique Alfandari, Constance C Angelou, Leonid A. Pobezinsky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbe7250444f8506f92f84df54dd92d3
https://doi.org/10.7554/elife.26398.028
https://doi.org/10.7554/elife.26398.028
