Výsledky vyhledávání - "Elena L. Harden"

Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Autor: Stephen M. Thirdborough, Gareth J. Thomas, Christopher H. Woelk, Jeongmin Woo, Oliver Wood, Jason Fleming, Veronika Jenei, Jana Stasakova, Elena L. Harden, Kate L. Perry, Christian H. Ottensmeier

Figure S3. Increased expression of the CD8+ T-cell signature has a prognostic value for overall survival. (A and B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of genes with the strongest membership (kME{

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5952b780779b474c6f12702231a203
https://doi.org/10.1158/0008-5472.22411931

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Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Figure S4. Pathway and survival analysis of genes negatively associated with the leukocyte module (M1) eigengene. (A) Each module whose eigengene inversely correlated with ME1 were represented as a node connected to some of the top-ranked genes (adj.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc7024e63dfdcb4bff31a5d27345a0b
https://doi.org/10.1158/0008-5472.22411928.v1

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Figure S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Figure S1. Overview of workflow.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130b26a8ff873375881a4817d7940519
https://doi.org/10.1158/0008-5472.22411937

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Figure S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Figure S2. Analysis of gene coexpression and eigengene relationships with overall survival. (A) Box-and-whisker plots of the Pearson correlation between a module gene's expression profile and the deviance residual, a measure of observed minus expecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dc43a62a665392468cb0e36af80008
https://doi.org/10.1158/0008-5472.22411934.v1

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Data from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a4224ea36aaf29a073eeb3b575e4788
https://doi.org/10.1158/0008-5472.c.6508331.v1

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Table S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Table S2. Excel spreadsheet of enriched GO terms (Bonferoni adj.P< 0.05) and top 20 negatively enriched MSigDB hallmark gene sets.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f507370295e546d561d44b2588d27c
https://doi.org/10.1158/0008-5472.22411919.v1

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Figure S5 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Figure S5. Magnitude and breadth of T-cell response to HPV-16 E7/E6 DNA vaccine. The E7/E6 DNA vaccine (VB1025) was obtained from Agnete Fredriksen and Ole Brekke (Vaccibody, Oslo, Norway). It encodes a HPV-16 E7/E6 fusion protein, which for safety r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e569a93977f4b3b1ba0739813bf9f41
https://doi.org/10.1158/0008-5472.22411925.v1

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Table S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Table S1. Complete list of identified modules in the HNSC network and their top GO Biological Process category.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a3c70843d8fa75affffc389fbbb24a
https://doi.org/10.1158/0008-5472.22411922.v1

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Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Table S3. Complete list of identified modules in the SCC consensus network and their top GO Biological Process category.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875ec9d32d5e5af38ae2c3289fc96b4e
https://doi.org/10.1158/0008-5472.22411916

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