Výsledky vyhledávání - "Elena Kurenova"

Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs

Autor: Leslie Curtin, Elena Kurenova, Laura Pitzonka, Sandra Sexton, William G. Cance, Gerald J. Fetterly, Allison Gaudy, John Wilton

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 41:55-67

Inhibition of focal adhesion kinase–vascular endothelial growth factor receptor 3 complex by C4 was previously shown to reduce tumor growth alone and synergistically with other chemotherapeutic agents in animal tumor models. Single and multiple dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3539ea6aec53e2b4b966ea216cc9b519
https://doi.org/10.1007/s13318-014-0233-6

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A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells

Autor: Ulas Sunar, Elena Kurenova, Wiam Bshara, Michael Yemma, Deniz A. Ucar, Mukund Seshadri, William G. Cance, Jianqun Liao, Steven N. Hochwald, Priyanka N. Gogate

Publikováno v: Cell Cycle. 13:2542-2553

Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e04ba911aa1b01ea4ead6b9543ca5b
https://doi.org/10.4161/15384101.2015.941760

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Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

Autor: Elena Kurenova, Manivannan Ethirajan, Ravindra K. Pandey, William G. Cance, Priyanka N. Gogate, Andrew T. Magis

Publikováno v: European Journal of Medicinal Chemistry. 80:154-166

Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor 3 (VEGFR3) are tyrosine kinases, which function as key modulators of survival and metastasis signals in cancer cells. Previously, we reported that small molecule chlorpyramin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9befe50a971e81f420f201344e6b4add
https://doi.org/10.1016/j.ejmech.2014.04.041

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The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth

Autor: Elena Kurenova, Darrell Hunt, Di-Hua He, William G. Cance, Mukund Seshadri, Wiam Bshara, Michael Yemma, Jianqun Liao

Publikováno v: Oncotarget

// Elena Kurenova 1,5 , Jianqun Liao 1 , Di-Hua He 4 , Darrell Hunt 4 , Michael Yemma 1 , Wiam Bshara 2 , Mukund Seshadri 3 , and William G. Cance 1,5 1 Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 2 Department of Patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a366499c11da796f587db852ad8472
http://europepmc.org/articles/PMC3858551

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Inhibition of FAK and VEGFR‐3 binding decreases tumorigenicity in neuroblastoma

Autor: Elena Kurenova, William G. Cance, Elizabeth A. Beierle, Hugh C. Nabers, Michael L. Megison, Xiaojie Ma, Jerry E. Stewart

Publikováno v: Molecular Carcinogenesis. 54:9-23

Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many facets of tumor development and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255bb3355b15956bba57ac91e5436a99
https://doi.org/10.1002/mc.22070

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Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines

Autor: Jerry E. Stewart, Elena Kurenova, Michael L. Megison, Xiaojie Ma, Elizabeth A. Beierle, William G. Cance

Publikováno v: Molecular Carcinogenesis. 53:230-242

Neuroblastoma continues to be a devastating childhood solid tumor and is responsible for over 15% of all childhood cancer-related deaths. Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) are protein tyrosine kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64ca75af43012269c59d158b0eeae7cc
https://doi.org/10.1002/mc.21969

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A Novel Small Molecule Inhibitor of FAK and IGF-1R Protein Interactions Decreases Growth of Human Esophageal Carcinoma

Autor: Di-Hua He, Steven N. Hochwald, Elena Kurenova, Deniz A. Ucar, David A. Ostrov, Audrey Cox

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 11:629-637

Introduction: Esophageal cancer remains an aggressive disease with poor survival rates. FAK and IGF-1R are two important tyrosine kinases important for cell survival signaling and found to be upregulated in esophageal cancer. Our hypothesis is that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0edf03189207131d62013c611e070d
https://doi.org/10.2174/187152011796817718

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Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor 3 and Suppresses Breast Cancer Growth in Vivo

Autor: Andrew T. Magis, William G. Cance, Darell L. Hunt, Di-Hua He, David A. Ostrov, Elena Kurenova

Publikováno v: Journal of Medicinal Chemistry. 52:4716-4724

FAK is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. Since FAK interacts directly with a number of critical proteins involved in survival signaling in tumor cells, we hypothesized that targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5596016bfc09815c57f5820cd6f1d699
https://doi.org/10.1021/jm900159g

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Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase

Autor: Vita M. Golubovskaya, Frederick Kweh, Margaret R. Wallace, William G. Cance, Elena Kurenova, Min Zheng

Publikováno v: Molecular Carcinogenesis. 48:1005-1017

The NF1 gene that is altered in patients with type 1 neurofibromatosis (NF1) encodes a neurofibromin protein that functions as a tumor suppressor. In this report, we show for the first time physical interaction between neurofibromin and focal adhesio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db782ef5f5a0824bacf271138b1a16ca
https://doi.org/10.1002/mc.20552

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