Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

Autor: Elena Khazina, Oliver Weichenrieder

Publikováno v: eLife, Vol 7 (2018)

LINE-1 (L1) is an autonomous retrotransposon, which acted throughout mammalian evolution and keeps contributing to human genotypic diversity, genetic disease and cancer. L1 encodes two essential proteins: L1ORF1p, a unique RNA-binding protein, and L1

Externí odkaz: https://doaj.org/article/08ec64a0f0644678af0fabe9bc2ae603

Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex

Autor: Ying Chen, Oliver Weichenrieder, Elena Khazina, Elisa Izaurralde

Publikováno v: Nucleic Acids Research

The CCR4 and CAF1 deadenylases physically interact to form the CCR4-CAF1 complex and function as the catalytic core of the larger CCR4-NOT complex. Together, they are responsible for the eventual removal of the 3′-poly(A) tail from essentially all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43234909dec428bb8a50b1285cb0d7b
https://doi.org/10.1093/nar/gkab414

Author response: Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

Autor: David Read, Carmen Salvador-Palomeque, Paula Peressini, Judith Reichmann, Marie MacLennan, Abigail R Mann, Laura Sánchez, Christopher J Playfoot, Jose L. Garcia-Perez, Ian R. Adams, Chao-Chun Hung, K. Dobie, Oliver Weichenrieder, Marta García-Cañadas, Richard R. Meehan, Ragnhild Eskeland, Gabriele Wagner, Elena Khazina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d830ec6ea6c934995e96a5942056f7d9
https://doi.org/10.7554/elife.26152.031

Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

Autor: Abigail R Mann, David Read, Judith Reichmann, Marie MacLennan, Oliver Weichenrieder, Christopher J Playfoot, Chao-Chun Hung, Richard R. Meehan, Elena Khazina, Gabriele Wagner, Ragnhild Eskeland, K. Dobie, Marta García-Cañadas, Laura Sánchez, Jose L. Garcia-Perez, Ian R. Adams, Carmen Salvador-Palomeque, Paula Peressini

Publikováno v: Maclennan, M, Garcia-Cañadas, M, Reichmann, J, Khazina, E, Wagner, G, Playfoot, C J, Salvador-Palomeque, C, Mann, A R, Peressini, P, Sanchez, L, Dobie, K, Read, D, Hung, C-C, Eskeland, R, Meehan, R R, Weichenrieder, O, García-Pérez, J L & Adams, I R 2017, ' Mobilization of LINE-1 Retrotransposons is Restricted by Tex19.1 in Mouse Embryonic Stem Cells ', eLIFE, vol. 6, e26152 . https://doi.org/10.7554/eLife.26152
eLife, Vol 6 (2017)

Mobilization of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders. In humans, retrotransposon mobilization is mediated primarily by proteins en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc3692ad88e57f979c75c684cb3bc25
http://hdl.handle.net/10852/64844

Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame

Autor: Elena Khazina, Oliver Weichenrieder

Publikováno v: Proceedings of the National Academy of Sciences. 106:731-736

Non-LTR retrotransposons (NLRs) are a unique class of mobile genetic elements that have significant impact on the evolution of eukaryotic genomes. However, the molecular details and functions of their encoded proteins, in particular of the accessory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ef0e8e8d1a75eccfafe0a6c4d41eb7
https://doi.org/10.1073/pnas.0809964106