Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elena K. Stamenova"'
Autor:
Hua-Jun Wu, Alexandro Landshammer, Elena K. Stamenova, Adriano Bolondi, Helene Kretzmer, Alexander Meissner, Franziska Michor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiat
Externí odkaz:
https://doaj.org/article/74703824e0ed457c97e98fe375a89f8b
Autor:
Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Jiang, Rafael C. Schulman, Kyu-Tae Kim, Alicia Alonso, John N. Allan, Richard R. Furman, Andreas Gnirke, Catherine J. Wu, Ari M. Melnick, Alexander Meissner, Bradley E. Bernstein, Omar Abdel-Wahab, Dan A. Landau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL ce
Externí odkaz:
https://doaj.org/article/84f8fc2c23c040aca441459292bfd167
Autor:
Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller, Alexander Meissner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.
Externí odkaz:
https://doaj.org/article/facfcb998fb94a91ab5dd5199cd3a1b4
Autor:
Alexander Meissner, Helene Kretzmer, Hua-Jun Wu, Adriano Bolondi, Elena K. Stamenova, Franziska Michor, Alexandro Landshammer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Precise control of mammalian gene expression is facilitated through epigenetic mechanisms and nuclear organization. In particular, insulated chromosome structures are important for regulatory control, but the phenotypic consequences of their boundary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd1b0447e37d3469e6a1fe94ed8a46
https://refubium.fu-berlin.de/handle/fub188/32537
https://refubium.fu-berlin.de/handle/fub188/32537
Autor:
Kendell Clement, Hans R. Schöler, Alexandra L. Mattei, Elena K. Stamenova, Julie Donaghey, Andreas Gnirke, Hongcang Gu, Alexander Meissner, Bernd Timmermann, Christina Galonska, Arman W. Mohammad, Jocelyn Charlton, Tobias Cantz, Sven Klages, Michael J. Ziller, Davide Cacchiarelli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
In normal mammalian development cytosine methylation is essential and is directed to specific regions of the genome. Despite notable advances through mapping its genome-wide distribution, studying the direct contribution of DNA methylation to gene an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8260fa2b5b9fb260d82664a9b5019a
https://doaj.org/article/facfcb998fb94a91ab5dd5199cd3a1b4
https://doaj.org/article/facfcb998fb94a91ab5dd5199cd3a1b4
Autor:
Julie Donaghey, Kendell Clement, Jennifer S. Chen, Andreas Gnirke, Casey A. Gifford, John L. Rinn, Michael J. Ziller, Ramona Pop, Rahul Karnik, Elena K. Stamenova, Jocelyn Charlton, David R. Kelley, Sudhir Thakurela, Hongcang Gu, Alexander Meissner, Zachary D. Smith, Davide Cacchiarelli
Publikováno v:
Nature Genetics
Transcription factors (TFs) direct developmental transitions by binding to target DNA sequences, influencing gene expression and establishing complex gene-regultory networks. To systematically determine the molecular components that enable or constra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5273312cc7fa87b8990e2f796a431aaf
https://doi.org/10.1038/s41588-017-0034-3
https://doi.org/10.1038/s41588-017-0034-3
Autor:
Ronan Chaligne, Alicia Alonso, Wendy Béguelin, Rafael C. Schulman, Hongcang Gu, Alexander Meissner, Sydney X. Lu, Ari Melnick, Kyu-Tae Kim, Ryan M. Brand, Federico Gaiti, Catherine J. Wu, Bradley E. Bernstein, Yanwen Jiang, Kevin Y. Huang, Elena K. Stamenova, Dan A. Landau, Scott Kulm, Omar Abdel-Wahab, John N. Allan, Alessandro Pastore, Andreas Gnirke, Richard R. Furman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively study the epigenetic dimension of cancer ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a41b6af21c41d9dd8e2e4b21cce2f92
https://doi.org/10.1038/s41467-019-09645-5
https://doi.org/10.1038/s41467-019-09645-5
Autor:
Nina Bailly, Andreas Gnirke, Alexander Meissner, Elena K. Stamenova, Eric J. Martin, Franz-Josef Müller, Jocelyn Charlton, Björn Brändl, Zachary D. Smith, Alexandra L. Mattei, Evangelos Kiskinis, Jing Liao, Pay Giesselmann, Eunmi J. Jung
Publikováno v:
Nature genetics
Nature Genetics
Nature Genetics
Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1–3) regulators. Here, we used wildtype and TET triple knockout human embryonic stem cells (ESCs), generated DNMT3-null as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ce075ae2104b28db36971ead4dd42c
https://pubmed.ncbi.nlm.nih.gov/32514123
https://pubmed.ncbi.nlm.nih.gov/32514123
Autor:
Sharon R. Grossman, Glen Munson, Joseph Nasser, Drew T. Bergman, Elizabeth M. Perez, Michael Kane, Elena K. Stamenova, Benjamin R. Doughty, Thouis R. Jones, Charles P. Fulco, Rockwell Anyoha, Eric S. Lander, Neva C. Durand, Tung T. Nguyen, Tejal A. Patwardhan, Vidya Subramanian, Jesse M. Engreitz, Erez Lieberman Aiden
Mammalian genomes harbor millions of noncoding elements called enhancers that quantitatively regulate gene expression, but it remains unclear which enhancers regulate which genes. Here we describe an experimental approach, based on CRISPR interferenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a9c53caf034ef390045c07f233f26d
https://doi.org/10.1101/529990
https://doi.org/10.1101/529990
Autor:
Sharon R. Grossman, Glen Munson, Charles P. Fulco, Thouis R. Jones, Tejal A. Patwardhan, Caleb A. Lareau, Drew T. Bergman, Jesse M. Engreitz, Vidya Subramanian, Elena K. Stamenova, Rockwell Anyoha, Benjamin R. Doughty, Elizabeth M. Perez, Erez Lieberman Aiden, Michael Kane, Eric S. Lander, Joseph Nasser, Tung T. Nguyen, Neva C. Durand
Publikováno v:
Nature genetics
Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1-4. Yet, we still do not know how enhancers regulate specific genes, and we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6989fecb3145849ffe92cac2428a3c
https://pubmed.ncbi.nlm.nih.gov/31784730
https://pubmed.ncbi.nlm.nih.gov/31784730