Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation

Autor: María Cristina Carbajo-García, Lucia de Miguel-Gómez, Elena Juárez-Barber, Alexandra Trelis, Javier Monleón, Antonio Pellicer, James M. Flanagan, Hortensia Ferrero

Publikováno v: Biomedicines, Vol 10, Iss 6, p 1279 (2022)

Uterine leiomyoma (UL) is a benign tumor arising from myometrium (MM) with a high prevalence and unclear pathology. Histone modifications are altered in tumors, particularly via histone acetylation which is correlated with gene activation. To identif

Externí odkaz: https://doaj.org/article/e782d98648474df29a16cee895a66303

Adjustment of progesterone administration after endometrial transcriptomic analysis does not improve reproductive outcomes in women with adenomyosis

Autor: Elena Juárez-Barber, Mauro Cozzolino, Ana Corachán, Diana Alecsandru, Nuria Pellicer, Antonio Pellicer, Hortensia Ferrero

Publikováno v: REPRODUCTIVE BIOMEDICINE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Do patients with adenomyosis present a dysregulated endometrial receptivity that can be reversed with personalized embryo transfer (PET) by transcriptomic-based progesterone adjustment, improving IVF outcomes?A multicentre, retrospective, cohort stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c49838ad9c6aae36737bbc7f6278f8
https://doi.org/10.1016/j.rbmo.2022.09.007

Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility

Autor: Elena Juárez-Barber, Emilio Francés-Herrero, Ana Corachán, Carmina Vidal, Juan Giles, Pilar Alamá, Amparo Faus, Antonio Pellicer, Irene Cervelló, Hortensia Ferrero

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 2; Pages: 219

Adenomyosis is related to infertility and miscarriages, but so far there are no robust in vitro models that reproduce its pathological features to study the molecular mechanisms involved in this disease. Endometrial organoids are in vitro 3D models t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997754114a8f9d6ce35cfb31d56104a7

EXTRACELLULAR VESICLES SECRETED BY ENDOMETRIAL ORGANOIDS FROM ADENOMYOSIS PATIENTS CONTAIN MIRNAS IMPLICATED IN DISEASE DEVELOPMENT, EMBRYO IMPLANTATION FAILURE AND PREGNANCY DISORDERS

Autor: Elena Juárez-Barber, Marina Segura-Benítez, Maria Cristina Carbajo-Garcia, Alba Bas-Rivas, Amparo Faus, Antonio Pellicer, Hortensia Ferrero

Publikováno v: Fertility and Sterility. 118:e200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d78376c3980f00c82446288359d49fe9
https://doi.org/10.1016/j.fertnstert.2022.08.569

DEVELOPMENT OF SECRETOR AND GESTATIONAL PATIENT-DERIVED ORGANOIDS FROM ADENOMYOSIS DISEASE AS AN IN VITRO MODEL TO STUDY ADENOMYOSIS-RELATED INFERTILITY AND PERSONALIZED DRUG SCREENING

Autor: Emilio Francés-Herrero, Irene Cervelló, Amparo Faus, Elena Juárez-Barber, Antonio Pellicer, Hortensia Ferrero, Ana Corachán

Publikováno v: Fertility and Sterility. 116:e310

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8b08f80cb2f62d35b4661601e78b9b8
https://doi.org/10.1016/j.fertnstert.2021.07.835