Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Elena J. Levin"'
Publikováno v:
PLoS Biology, Vol 12, Iss 7, p e1001911 (2014)
Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport, incl
Externí odkaz:
https://doaj.org/article/777d338b0ead40fd9973724674f702bc
Autor:
Jason G. McCoy, Ming Zhou, Wonpil Im, Jumin Lee, Sébastien F. Poget, Zhenning Ren, Sharmistha Mitra, Elena J. Levin, Vitali Stanevich, Matthias Quick
Publikováno v:
Structure. 24:956-964
The phosphoenolpyruvate:carbohydrate phosphotransferase systems are found in bacteria, where they play central roles in sugar uptake and regulation of cellular uptake processes. Little is known about how the membrane-embedded components (EIICs) selec
Autor:
Jason G. McCoy, Pablo Sobrado, Kanagalaghatta R. Rajashankar, Elena J. Levin, Yonghong Bai, Brian G. Fox, Ming Zhou
Publikováno v:
Nature
Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first double bond into saturated fatty acyl-CoAs1–4. Since the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters, and tri
Autor:
Elena J. Levin, Ming Zhou
Publikováno v:
Current Opinion in Structural Biology. 27:95-101
Members of the Superfamily of K(+) Transporters (SKT) are integral membrane proteins that mediate the uptake of ions into non-animal cells. Although these proteins are homologous to the well-characterized K(+) channel family, relatively little was kn
Autor:
Brian Kloss, Renato Bruni, Ming Zhou, Jason G. McCoy, Yaping Pan, Ruchika Sharma, Xiaoming Zhou, Matthias Quick, Elena J. Levin
Publikováno v:
Nature
Bile acids are synthesized from cholesterol in hepatocytes and secreted through the biliary tract into the small intestine, where they aid in absorption of lipids and fat-soluble vitamins. Through a process known as enterohepatic recirculation, more
Publikováno v:
Nature
TrkH belongs to a superfamily of K(+) transport proteins required for growth of bacteria in low external K(+) concentrations. The crystal structure of TrkH from Vibrio parahaemolyticus showed that TrkH resembles a K(+) channel and may have a gating m
Publikováno v:
ACS Chemical Biology. 7:1641-1646
The Kv1 family voltage-dependent K(+) channels are essential for termination of action potentials in neurons and myocytes. These channels form a stable complex with their beta subunits (Kvβ), some of which inhibit channel activity. Cortisone potenti
Autor:
Ming Zhou, Giray Enkavi, Elena J. Levin, Matthias Quick, Emad Tajkhorshid, Yaping Pan, Yu Cao
Publikováno v:
Proceedings of the National Academy of Sciences. 109:11194-11199
As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative ure
Autor:
Hua Huang, Ming Zhou, Wayne A. Hendrickson, Yaping Pan, Marco Punta, J. Love, Jun Weng, Elena J. Levin, Yu Cao, Kanagalaghatta R. Rajashankar, Burkhard Rost, Jonathan A. Javitch, Yinong Zong, Matthias Quick, Xiangshu Jin
Publikováno v:
Nature. 473:50-54
Saccharides have a central role in the nutrition of all living organisms. Whereas several saccharide uptake systems are shared between the different phylogenetic kingdoms, the phosphoenolpyruvate-dependent phosphotransferase system exists almost excl
Autor:
Yaping Pan, Ming Zhou, Wayne A. Hendrickson, Venkataraman Kabaleeswaran, Yu Cao, Brian Kloss, Hua Huang, Youxing Jiang, Kanagalaghatta R. Rajashankar, Jun Weng, Mehabaw G. Derebe, Renato Bruni, Elena J. Levin, Xiangshu Jin, Burkhard Rost, Matthias Quick, Sheng Ye, Marco Punta, J. Love, Jonathan A. Javitch, Erik Martinez-Hackert
Publikováno v:
Nature
The TrkH/TrkG/KtrB proteins mediate K+ uptake in bacteria and probably evolved from simple K+ channels by multiple gene duplications or fusions. Here we present the crystal structure of a TrkH from Vibrio parahaemolyticus. TrkH is a homodimer, and ea