Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Elena I Frolova"'
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0251834 (2021)
Structural characterization of the SARS-CoV-2 full length nsp1 protein will be an essential tool for developing new target-directed antiviral drugs against SARS-CoV-2 and for further understanding of intra- and intermolecular interactions of this pro
Externí odkaz:
https://doaj.org/article/3141d3b1f66d4717bc43efadb9c5ce94
Autor:
Dal Young Kim, Josephine M Reynaud, Aliaksandra Rasalouskaya, Ivan Akhrymuk, James A Mobley, Ilya Frolov, Elena I Frolova
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005810 (2016)
The positive-strand RNA viruses initiate their amplification in the cell from a single genome delivered by virion. This single RNA molecule needs to become involved in replication process before it is recognized and degraded by cellular machinery. In
Externí odkaz:
https://doaj.org/article/789ea1f2e72547d9a4c2d2f5edb3e7ba
Autor:
Josephine M Reynaud, Dal Young Kim, Svetlana Atasheva, Aliaksandra Rasalouskaya, James P White, Michael S Diamond, Scott C Weaver, Elena I Frolova, Ilya Frolov
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004863 (2015)
Alphaviruses are a group of widely distributed human and animal pathogens. It is well established that their replication is sensitive to type I IFN treatment, but the mechanism of IFN inhibitory function remains poorly understood. Using a new experim
Externí odkaz:
https://doaj.org/article/d5f44adea06b407abcdaf1bf803be5a5
Autor:
Ilya Frolov, Tatiana Agback, Oksana Palchevska, Francisco Dominguez, Alexander Lomzov, Peter Agback, Elena I. Frolova
Publikováno v:
Journal of Virology. 97
The nsp1 of SARS-CoV-2 is a multifunctional protein that modifies the intracellular environment for the needs of viral replication. It is responsible for the development of translational shutoff, and its expression alone is sufficient to cause a cyto
Autor:
Peter Agback, Tatiana Agback, Francisco Dominguez, Elena I. Frolova, Gulaim A. Seisenbaeva, Vadim G. Kessler
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The ongoing world-wide Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic shows the need for new potential sensing and therapeutic means against the CoV viruses. The SARS-CoV-2 nsp1 protein is important, both for replication and pa
Autor:
Elena I. Frolova, Oksana Palchevska, Tetyana Lukash, Francisco Dominguez, William Britt, Ilya Frolov
Publikováno v:
Journal of Virology. 96
Circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population leads to further viral evolution. The new variants that arise during this evolution are more infectious. Our data suggest that newer variants have shi
Autor:
A. S. Semkina, Stepan P. Chumakov, Dmitry Sergeevich Kravchenko, Elena I. Frolova, Elizaveta Sergeevna Podshivalova
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 110-118 (2021)
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 110-118 (2021)
Many members of the enterovirus family are considered as promising oncolytic agents; however, their systemic administration is largely inefficient due to the rapid neutralization of the virus in the circulation and the barrier functions of the endoth
Autor:
Awadalkareem Adam, Samantha R. Osman, Scott C. Weaver, Kenneth S. Plante, Bi Hung Peng, Elena I. Frolova, Huanle Luo, Ilya Frolov, Albert J. Auguste, Binbin Wang, Tian Wang, Christopher M. Roundy, Saravanan Thangamani
Publikováno v:
Emerging Microbes & Infections
article-version (VoR) Version of Record
article-version (VoR) Version of Record
A chimeric Eilat/ Chikungunya virus (EILV/CHIKV) was previously reported to replicate only in mosquito cells but capable of inducing robust adaptive immunity in animals. Here, we initially selected C7/10 cells to optimize the production of the chimer
Autor:
Vladislav Yu. Orekhov, Tetyana Lukash, Yulia Pustovalova, Francisco Dominguez, Peter Agback, Nikita Shiliaev, Tatiana Agback, Elena I. Frolova, Ilya Frolov
Publikováno v:
Virology
Alphavirus nsP3 proteins contains long, intrinsically disordered, hypervariable domains, HVD, which serve as hubs for interaction with many cellular proteins. Here, we have deciphered the mechanism and function of HVD interaction with host factors in
Autor:
David K. Crossman, Tetyana Lukash, Ilya Frolov, Elena I. Frolova, Michael R. Crowley, Nikita Shiliaev, Todd Green, Oksana Palchevska
Publikováno v:
Journal of Virology. 95
One of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virulence factors is the ability to interact with high affinity to the ACE2 receptor, which mediates viral entry into cells. The results of our study demonstrate that within a fe