Derivation and internal validation of a multi-biomarker-based cardiovascular disease risk prediction score for rheumatoid arthritis patients

Autor: Jeffrey R. Curtis, Fenglong Xie, Cynthia S. Crowson, Eric H. Sasso, Elena Hitraya, Cheryl L. Chin, Richard D. Bamford, Rotem Ben-Shachar, Alexander Gutin, Darl D. Flake, Brent Mabey, Jerry S. Lanchbury

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-16 (2020)

Abstract Background Rheumatoid arthritis (RA) patients have increased risk for cardiovascular disease (CVD). Accurate CVD risk prediction could improve care for RA patients. Our goal is to develop and validate a biomarker-based model for predicting C

Externí odkaz: https://doaj.org/article/820d16f7ed664ae9a9f478596526797d

Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis

Autor: Carol J. Etzel, Elena Hitraya, Michael E. Weinblatt, Eric H. Sasso, Jeffrey R. Curtis, Nancy A. Shadick, Alexander Gutin, Daniel E. Furst, Xingbin Wang, Merete Lund Hetland, Jerry S. Lanchbury, Darl D. Flake, Mikkel Østergaard, Dimitrios A. Pappas, C.C. Hwang, Yong Gil Hwang, Cecilie Heegaard Brahe, Vibeke Strand

Publikováno v: Rheumatology (Oxford, England)
Curtis, J R, Flake, D D, Weinblatt, M E, Shadick, N A, Østergaard, M, Hetland, M L, Brahe, C H, Hwang, Y G, Furst, D E, Strand, V, Etzel, C J, Pappas, D A, Wang, X, Hwang, C C, Sasso, E H, Gutin, A, Hitraya, E & Lanchbury, J S 2019, ' Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis ', Rheumatology, vol. 58, no. 5, pp. 874-883 . https://doi.org/10.1093/rheumatology/key367

Objective To develop and evaluate an adjusted score for the multi-biomarker disease activity (MBDA) test to account for the effects of age, sex and adiposity in patients with RA. Methods Two models were developed to adjust MBDA score for age, sex and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fef7ca3b26e53ff62522abe7b5532e
https://doi.org/10.1093/rheumatology/key367

AB0289 PREDICTION OF CARDIOVASCULAR EVENTS IN RHEUMATOID ARTHRITIS PATIENTS USING PROTEIN BIOMARKERS AND CLINICAL FACTORS

Autor: Fenglong Xie, Elena Hitraya, Jeffrey R. Curtis, Jerry S. Lanchbury, Cynthia S. Crowson, Lang Chen, Darl D. Flake, Alexander Gutin, Cheryl Chin, Eric H. Sasso

Publikováno v: Abstracts Accepted for Publication.

Background The ACC/AHA recommends preventive strategies for patients with a high-predicted risk of atherosclerotic cardiovascular disease (CVD). RA patients are at higher risk for CVD events, yet the role of systemic inflammation and the influence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a8f1f6e4a96b1a841045c84d1e64685
https://doi.org/10.1136/annrheumdis-2019-eular.6323

Relationship Between Baseline and Early Changes in C‐Reactive Protein and Interleukin‐6 Levels and Clinical Response to Tocilizumab in Rheumatoid Arthritis

Autor: Elena Hitraya, Jason M. Low, Dale Yu, Jenny Devenport, Jianmei Wang

Publikováno v: Arthritis Care & Research

OBJECTIVE To clarify the relevance of measuring interleukin-6 (IL-6) and C-reactive protein (CRP) levels in order to predict clinical response to tocilizumab (TCZ) in rheumatoid arthritis patients. METHODS In a pooled, post hoc analysis of 5 pivotal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c318439a72635c37e9fb40d3beb93161
http://europepmc.org/articles/PMC6120137

AB0244 Development of an adjusted multi-biomarker disease activity (MBDA) score for rheumatoid arthritis (RA) that accounts for age, sex and adiposity, with subsequent evaluation of ability to predict risk for radiographic damage

Autor: E. Sasso, Michael E. Weinblatt, C. Heegaard Brahe, Carol J. Etzel, Jerry S. Lanchbury, Nancy A. Shadick, Yong Gil Hwang, M.L. Hetland, Daniel E. Furst, Mikkel Østergaard, Elena Hitraya, Jeffrey R. Curtis, Darl D. Flake, Dimitrios A. Pappas, C.C. Hwang, Alexander Gutin, Vibeke Strand, Xiaoyan Wang

Publikováno v: Rheumatoid arthritis – prognosis, predictors and outcome.

Background The MBDA score, based on 12 serum proteins, is a validated tool for assessing disease activity in RA patients. MBDA biomarkers may be influenced by age, sex and adiposity. Objectives To develop and validate an adjusted MBDA score that acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a11130fb4adb8761d6349072867fbec1
https://doi.org/10.1136/annrheumdis-2018-eular.7133