CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

Autor: Dorota Kmiec, Rayhane Nchioua, Scott Sherrill-Mix, Christina M. Stürzel, Elena Heusinger, Elisabeth Braun, Marcos V. P. Gondim, Dominik Hotter, Konstantin M. J. Sparrer, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff

Publikováno v: mBio, Vol 11, Iss 1 (2020)

ABSTRACT CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked differences in CpG frequencies across their genome, ranging

Externí odkaz: https://doaj.org/article/7fb955a32f4b4d7485d84d077ece1b08

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

Autor: Scott Sherrill-Mix, Beatrice H. Hahn, Konstantin M. J. Sparrer, Dorota Kmiec, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Elisabeth Braun, Marcos V. P. Gondim, Elena Heusinger, Rayhane Nchioua, Dominik Hotter

Publikováno v: mBio
mBio, Vol 11, Iss 1, p e02903-19 (2020)
mBio, Vol 11, Iss 1 (2020)

Evasion of the zinc-finger antiviral protein (ZAP) may drive CpG dinucleotide suppression in HIV-1 and many other viral pathogens but the viral determinants of ZAP sensitivity are poorly defined. Here, we examined CpG suppression and ZAP sensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6c83c2ae307b860feb158463ca5cc3
http://europepmc.org/articles/PMC6960287

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Autor: Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter

Publikováno v: Braun, E, Hotter, D, Koepke, L, Zech, F, Groß, R, Sparrer, K M J, Müller, J A, Pfaller, C K, Heusinger, E, Wombacher, R, Sutter, K, Dittmer, U, Winkler, M, Simmons, G, Jakobsen, M R, Conzelmann, K-K, Pöhlmann, S, Münch, J, Fackler, O T, Kirchhoff, F & Sauter, D 2019, ' Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins ', Cell Reports, vol. 27, no. 7, pp. 2092-2104.e10 . https://doi.org/10.1016/j.celrep.2019.04.063
Cell Reports, Vol 27, Iss 7, Pp 2092-2104.e10 (2019)

Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce42d3598f7f2ed441bb62c400826919
https://pubmed.ncbi.nlm.nih.gov/31091448

HIV-1 Nefs are cargo-sensitive AP-1 trimerization switches in tetherin and MHC-I downregulation

Autor: Kyle L. Morris, Christina M. Stürzel, Xuefeng Ren, Frank Kirchhoff, James H. Hurley, Cosmo Z. Buffalo, Elena Heusinger

SummaryThe HIV accessory protein Nef counteracts immune defenses by subverting coated vesicle pathways. The 3.7 Å cryo-EM structure of a closed trimer of the clathrin adaptor AP-1, the small GTPase Arf1, HIV-1 Nef, and the cytosolic tail of the rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0ffe06add2ddba852312cc98ef455f

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

Autor: Elena Heusinger, Frank Kirchhoff

Publikováno v: Frontiers in Microbiology

The transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) plays a complex role during the replication of primate lentiviruses. On the one hand, NF-κB is essential for induction of efficient proviral gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0605c6d8e9422332a6df76934a33bbd1
http://europepmc.org/articles/PMC5306280