Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elena Gustchina"'
Autor:
Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G Marius Clore, Alexander Wlodawer
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78187 (2013)
A series of mini-antibodies (monovalent and bivalent Fabs) targeting the conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 has been previously constructed and reported. Crystal structures of two closely related monov
Externí odkaz:
https://doaj.org/article/1a35b1013b964c889319795eda95b490
Autor:
Elena Gustchina, Mi Li, John M Louis, D Eric Anderson, John Lloyd, Christian Frisch, Carole A Bewley, Alla Gustchina, Alexander Wlodawer, G Marius Clore
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001182 (2010)
The conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 is transiently exposed during the fusion process by forming a pre-hairpin intermediate, thus representing an attractive target for the design of fusion inhibitors
Externí odkaz:
https://doaj.org/article/7a8b072d58944f4494d167672c79b7b2
Autor:
Elena Gustchina, Kevin L. Williams
Publikováno v:
Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems ISBN: 9783030171476
This Chapter provides an overview of ancient metazoan proteins that are made to interface (detect and control) microbes and microbial artifacts (PAMPs), especially endotoxin. The intention is to prepare readers for the more complex chapters in the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbf0bfa1f49a819913061d673ed4ecc
https://doi.org/10.1007/978-3-030-17148-3_18
https://doi.org/10.1007/978-3-030-17148-3_18
Autor:
John M. Louis, Francisco Ylera, Christian Frisch, Annette Lechner, G. Marius Clore, Carole A. Bewley, Elena Gustchina
Publikováno v:
Virology. 393:112-119
Previously we reported a broadly HIV-1 neutralizing mini-antibody (Fab 3674) of modest potency that was derived from a human non-immune phage library by panning against the chimeric gp41-derived construct N(CCG)-gp41. This construct presents the N-he
Publikováno v:
Journal of Virology. 82:10032-10041
Human immunodeficiency virus type 1 (HIV-1) infection is initiated by fusion of the virus with the target cell membrane (1, 11, 19, 40, 43, 51). The initial event involves the binding of the envelope (Env) protein gp120 first to CD4 and subsequently
Publikováno v:
Journal of Molecular Biology. 364:283-289
The human immunodeficiency virus type-1 (HIV-1) envelope (Env) proteins that mediate membrane fusion represent a major target for the development of new AIDS therapies. Three classes of Env-mediated membrane fusion inhibitors have been described that
Publikováno v:
Journal of Medicinal Chemistry. 48:3036-3044
The spectrum of inhibition of human (HIV) and simian (SIV) immunodeficiency virus envelope (Env)-mediated cell fusion by C34, a 34 residue peptide corresponding to the C-heptad repeat of gp41 (residues 628-661 of HIV-1 Env), has been examined using a
Autor:
Elena Afonina, Betty Yu, Elena Gustchina, Young Ho Kim, Abelardo M. Silva, John W. Erickson, Sergei V. Gulnik
Publikováno v:
Protein Expression and Purification. 24:412-419
Plasmepsin-2 is a malarial aspartic proteinase that has been implicated in the initial steps of hemoglobin degradation in parasites and thus represents an attractive antimalarial target. Escherichia coli expressed proplasmepsin-2 is capable of activa
Autor:
Dorien de Jong, Pauline J. Schipper, Sergei V. Gulnik, John W. Erickson, Rob Schuurman, Monique Nijhuis, Jan Albert, Charles A. Boucher, Elena Gustchina
Publikováno v:
AIDS. 13:2349-2359
Objective It is thought as a consequence of continuous replication, HIV-1 has acquired an optimal fitness state and that suboptimal antiretroviral therapy selects for drug resistant variants which show impaired fitness in the absence of the drug. In
Autor:
Sergei V. Gulnik, Leonid I. Suvorov, Elena Gustchina, Laura Collins, Dong Xie, John W. Erickson
Publikováno v:
Biochemistry. 36:16166-16172
The catalytic activity and inhibitor binding energetics of enzymes are often pH-dependent properties. Aspartic proteases comprise an important class of enzyme targets for structure-based drug design. We have performed a complete thermodynamic study o