Searching for New NO-Donor Aspirin-like Molecules: A New Class of Nitrooxy-acyl Derivatives of Salicylic Acid

Autor: Giuseppina Morini, Ennio Ongini, Roberta Fruttero, Loretta Lazzarato, Gabriella Coruzzi, Elena Guaita, Monica Donnola, Stefano Biondi, Alberto Gasco, Barbara Rolando, Elisabetta Marini, Clara Cena

Publikováno v: Journal of Medicinal Chemistry. 51:1894-1903

A new class of products in which the phenol group of salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The products were stable in acid and neutral media, while the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092d64c5edf26535b786ca1574c4ea03
https://doi.org/10.1021/jm701104f

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

Autor: Roberta Fruttero, Stefano Guglielmo, Barbara Rolando, Giuseppina Morini, Elena Guaita, Alberto Gasco, Elisabetta Marini, Loretta Lazzarato, Gabriella Coruzzi, Marco Lucio Lolli, Clara Cena

Publikováno v: Bioorganicmedicinal chemistry. 19(19)

A new group of derivatives of salicylic acid containing NO-donor furoxans, and the related des-NO-furazans, were synthesized and evaluated as new aspirin-like molecules. Their stability was assessed in acid (pH 1) and physiological solutions (pH 7.4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c68fd5c02de3d1543604cedd26c384a
https://pubmed.ncbi.nlm.nih.gov/21906954

Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities

Autor: Donatella Boschi, Elena Guaita, Alberto Gasco, Marta Giorgis, Antonella Di Stilo, Giuseppina Morini, Clara Cena, Roberta Fruttero, Naveen Chandra Talniya, Gabriella Coruzzi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ea4ec807e1035b033bef8643af7ec5
http://hdl.handle.net/2318/76276

Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach

Autor: Obbe P. Zuiderveld, Eric E. J. Haaksma, Kamonchanok Sansuk, Adami M, Joachim Broeker, Gabriella Coruzzi, Rob Leurs, Rogier A. Smits, Elena Guaita, Iwan J. P. de Esch

Publikováno v: Journal of medicinal chemistry. 51(24)

From a series of small fragments that was designed to probe the histamine H(4) receptor (H(4)R), we previously described quinoxaline-containing fragments that were grown into high affinity H(4)R ligands in a process that was guided by pharmacophore m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c6e89c5c9a0eb9d819e19f66e22569
https://pubmed.ncbi.nlm.nih.gov/19053770

Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation

Autor: Iwan J. P. de Esch, Gabriella Coruzzi, Elena Guaita, Rob Leurs, Maristella Adami

Publikováno v: Coruzzi, G, Adami, M, Guaita, E, de Esch, I J P & Leurs, R 2007, ' Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation ', European Journal of Pharmacology, vol. 563, no. 1-3, pp. 240-4 . https://doi.org/10.1016/j.ejphar.2007.02.026
European Journal of Pharmacology, 563(1-3), 240-4. Elsevier

The effects of the highly selective histamine H4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85e8a49434efc5f33842051fe87ee9
https://research.vu.nl/en/publications/104d70f0-0028-4cc8-a5b3-cfdd155e8245