Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elena Gorovits"'
Autor:
Jin Wang, Andrea Hall, Geoffrey W. Henson, Brenda Ames, Mohamed Aljarah, Andrea Brancale, Elena Gorovits, Arnaud Gilles, John Vernachio, Karolina Madela, Babita Ganguly, Stanley D. Chamberlain, Jerry Muhammad, Nicola Zonta, Joseph M. Patti, Jeff T. Hutchins, Christopher McGuigan, Alexander A. Kolykhalov
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4850-4854
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of th
Autor:
Andrea Hall, Christopher McGuigan, K. Dawn Bryant, Babita Ganguly, Arnaud Gilles, Robin Walters, Jerry Muhammad, John Vernachio, Mohamed Aljarah, Nicholas Raja, Elena Gorovits, Geoffrey W. Henson, Jin Wang, Sabrina Holl, Damound Hunley, Brenda Ames, Alexander A. Kolykhalov, Stanley D. Chamberlain, Karolina Madela, Yule Liu, Sarah Jones, Jeff T. Hutchins
Publikováno v:
Journal of Medicinal Chemistry. 53:4949-4957
Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy, and selectivity are recognized as likely key components of future HCV therapy. 2'-C-Methylgua
Autor:
John Vernachio, Jeff T. Hutchins, Andrea Hall, Paul Domanski, Elena Gorovits, Brenda Ames, Cathy Y. Chang, Joseph M. Patti, Peter J. Syribeys
Publikováno v:
Microbial Pathogenesis. 43:55-66
Enterococci are opportunistic pathogens known to cause numerous clinical infections and complications in humans. Adhesin-mediated binding to extracellular matrix (ECM) proteins of the host is thought to be a crucial step in the pathogenesis of these
Autor:
Joseph M. Patti, Bradley D. Prater, Brenda Ames, Yule Liu, John Vernachio, Elena Gorovits, Peter J. Syribeys
Publikováno v:
Infection and Immunity. 72:6237-6244
Staphylococcus capitis ( S. capitis ) has been implicated in a large proportion of coagulase-negative staphylococcal infections in very-low-birth-weight infants. To identify potential therapeutic targets, the S. capitis genome was probed for the pres
Autor:
Andrea Hall, Patel Pratisksha, Jeff T. Hutchins, Michael A. Johnson, Julia M. Ross, John Vernachio, Elena Gorovits, Paul Domanski, Peter J. Syribeys, Joseph M. Patti
Publikováno v:
Infection and Immunity. 71:6864-6870
The Staphylococcus aureus MSCRAMM (microbial surface components recognizing adhesive matrix molecules) protein clumping factor A (ClfA) has been shown to be a critical virulence factor in several experimental models of infection. This report describe
Autor:
Jerry Muhammad, Babita Ganguly, Claire Bourdin, Stanley D. Chamberlain, Jeff T. Hutchins, Joseph M. Patti, C. Robin Walters, Andrea Brancale, Alexander A. Kolykhalov, Changalvala V. S. Ramamurty, Christopher McGuigan, Jin Wang, Aleksandr Obikhod, K. Dawn Bryant, Srinivas K. Battina, Elena Gorovits, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Damound Hunley, C.Srivinas Rao
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV) replication. We previou
Autor:
Maria A. Arrica, Jeff T. Hutchins, Jerry Muhammad, C. Robin Walters, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Karolina Madela, Claire Bourdin, K. Dawn Bryant, Damound Hunley, Aleksandr Obikhod, Alexander A. Kolykhalov, Elena Gorovits, Joseph M. Patti, Jin Wang, Emma Barrett, Srinivas K. Battina, Christopher McGuigan, Mohamed Aljarah, Stanley D. Chamberlain, Sarah Jones, Changalvala V. S. Ramamurty, Babita Ganguly
Publikováno v:
Journal of medicinal chemistry. 54(24)
We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and asy
Autor:
Geoffrey W. Henson, Jin Wang, K. Dawn Bryant, Christopher McGuigan, Brenda Ames, Joseph M. Patti, Karen Williams, Alexander A. Kolykhalov, Yule Liu, Mohamed Aljarah, Elena Gorovits, Jeff T. Hutchins, Jerry Muhammad, Blair Bleiman, John Vernachio, Damound Hunley, Nicholas Raja, Andrea Hall, Karolina Madela, Arnaud Gilles, Babita Ganguly, C. Robin Walters, Stanley D. Chamberlain
Publikováno v:
Antimicrobial agents and chemotherapy. 55(5)
INX-08189 is an aryl-phosphoramidate of 6- O -methyl-2′- C -methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10 ± 6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral r
Autor:
Andrea Hall, Jeff T. Hutchins, Christopher Mcguigan, John Vernachio, Nicholas Raja, Stanley D. Chamberlain, Mohamed Aljarah, Karolina Madela, Elena Gorovits, Sarah Jones, Joseph M. Patti, Jerry Muhammad, Geoffrey W. Henson, Jianfeng Wang
Publikováno v:
Hepatology. 52
Autor:
Peter J. Syribeys, Paul Domanski, Andrea Hall, Elena Gorovits, Jeff T. Hutchins, Patel Pratisksha, John Vernachio, Bradley D. Prater, Joseph M. Patti
Publikováno v:
Hybridoma (2005). 26(1)
Staphylococcus epidermidis is an important opportunistic human pathogen that has recently emerged as a major cause of foreign-body infections. The most important stage contributing to the pathogenesis of this bacteria is the initial adherence to host