Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Elena G Govorunova"'
Autor:
Hai Li, Chia-Ying Huang, Elena G Govorunova, Oleg A Sineshchekov, Adrian Yi, Kenneth J Rothschild, Meitian Wang, Lei Zheng, John L Spudich
Publikováno v:
eLife, Vol 10 (2021)
The crystal structure of the light-gated anion channel GtACR1 reported in our previous Research Article (Li et al., 2019) revealed a continuous tunnel traversing the protein from extracellular to intracellular pores. We proposed the tunnel as the con
Externí odkaz:
https://doaj.org/article/208c79efe15242c0b4dc9b15775668c3
Autor:
Hai Li, Chia-Ying Huang, Elena G Govorunova, Christopher T Schafer, Oleg A Sineshchekov, Meitian Wang, Lei Zheng, John L Spudich
Publikováno v:
eLife, Vol 8 (2019)
The anion channelrhodopsin GtACR1 from the alga Guillardia theta is a potent neuron-inhibiting optogenetics tool. Presented here, its X-ray structure at 2.9 Å reveals a tunnel traversing the protein from its extracellular surface to a large cytoplas
Externí odkaz:
https://doaj.org/article/dc5f01ec33e24dd39c42f7fc3d5655d0
Autor:
Elena G Govorunova, Mustapha Moussaif, Andrey Kullyev, Ken C Q Nguyen, Thomas V McDonald, David H Hall, Ji Y Sze
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10368 (2010)
The C. elegans eat-6 gene encodes a Na(+), K(+)-ATPase alpha subunit and is a homolog of the familial hemiplegic migraine candidate gene FHM2. Migraine is the most common neurological disorder linked to serotonergic dysfunction. We sought to study th
Externí odkaz:
https://doaj.org/article/8c7b9971e28545caaf9c78b9d428aed3
Autor:
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G. Govorunova, Oleg A. Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S. Brown, John L. Spudich, Oliver P. Ernst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found univ
Externí odkaz:
https://doaj.org/article/4df751c792bb444bae38a92d509b0e3d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/91faa785b73c46f4aa6371775e73028f
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
Since their discovery 21 years ago, channelrhodopsins have come of age and have become indispensable tools for optogenetic control of excitable cells such as neurons and myocytes. Potential therapeutic utility of channelrhodopsins has been proven by
Externí odkaz:
https://doaj.org/article/60ae3b0e30ae45f2995e7c4c5d63c21a
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, Ana-Nicoleta Bondar, John L. Spudich
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic si
Externí odkaz:
https://doaj.org/article/6c367106a20741388c92353aaae743a9
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Cation and anion channelrhodopsins (CCRs and ACRs, respectively) from phototactic algae have become widely used as genetically encoded molecular tools to control cell membrane potential with light. Recent advances in polynucleotide sequencing, especi
Externí odkaz:
https://doaj.org/article/4732426eee32484f9f1c17bbb8bc6782
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Hai Li, Yumei Wang, Leonid S. Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K.-S. Wong, John L. Spudich
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Cation and anion channelrhodopsins (CCRs and ACRs, respectively) primarily from two algal species, Chlamydomonas reinhardtii and Guillardia theta, have become widely used as optogenetic tools to control cell membrane potential with light. We
Externí odkaz:
https://doaj.org/article/c53e961158494961a6504a84794cf01b
Autor:
Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li, Yumei Wang, Michael Melkonian, Gane K.-S. Wong, Leonid S. Brown, John L. Spudich
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Channelrhodopsins guide algal phototaxis and are widely used as optogenetic probes for control of membrane potential with light. “Bacteriorhodopsin-like” cation channelrhodopsins (BCCRs) from cryptophytes differ in primary structure from
Externí odkaz:
https://doaj.org/article/9e1672b12d674b958bd9f2860372ea25