Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Elena F. Shevtsova"'
Autor:
Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil’eva, Andrey V. Maltsev, Pavel N. Shevtsov, Alexander V. Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract All forms of dementia including Alzheimer’s disease are currently incurable. Mitochondrial dysfunction and calcium alterations are shown to be involved in the mechanism of neurodegeneration in Alzheimer’s disease. Previously we have desc
Externí odkaz:
https://doaj.org/article/65ffb49b09fd4bf48fa46b6b76b2a84c
Autor:
Maria A. Lapshina, Elena F. Shevtsova, Vladimir V. Grigoriev, Aleksey Yu. Aksinenko, Aleksey A. Ustyugov, Daniil A. Steinberg, Grigoriy V. Maleev, Elena S. Dubrovskaya, Tatiana V. Goreva, Tatiana A. Epishina, Vladimir L. Zamoyski, Galina F. Makhaeva, Vladimir P. Fisenko, Ivan M. Veselov, Daria V. Vinogradova, Sergey O. Bachurin
Publikováno v:
Molecules, Vol 28, Iss 22, p 7567 (2023)
Currently, there are no effective drugs for the treatment of amyotrophic lateral sclerosis (ALS). Only two drugs—edaravone and riluzole—have been approved, but they have very limited efficacy. The aim of this work was to modify the structural cor
Externí odkaz:
https://doaj.org/article/c01932bd2b0347959d1155a33c3b5f8d
Autor:
Kseniya N. Sedenkova, Denis N. Leschukov, Yuri K. Grishin, Nikolay A. Zefirov, Yulia A. Gracheva, Dmitry A. Skvortsov, Yanislav S. Hrytseniuk, Lilja A. Vasilyeva, Elena A. Spirkova, Pavel N. Shevtsov, Elena F. Shevtsova, Alina R. Lukmanova, Vasily V. Spiridonov, Alina A. Markova, Minh T. Nguyen, Alexander A. Shtil, Olga N. Zefirova, Alexander A. Yaroslavov, Elena R. Milaeva, Elena B. Averina
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1499 (2023)
Tubulin-targeting agents attract undiminished attention as promising compounds for the design of anti-cancer drugs. Verubulin is a potent tubulin polymerization inhibitor, binding to colchicine-binding sites. In the present work, a series of verubuli
Externí odkaz:
https://doaj.org/article/d15585dc1f164f22bf292e2c887d7428
Autor:
Ivan M. Veselov, Daria V. Vinogradova, Andrey V. Maltsev, Pavel N. Shevtsov, Elena A. Spirkova, Sergey O. Bachurin, Elena F. Shevtsova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14450 (2023)
This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 di
Externí odkaz:
https://doaj.org/article/27b53a80b455498bb999354c3fafc63d
Autor:
Alexander M. Efremov, Olga V. Beznos, Roman O. Eremeev, Natalia B. Chesnokova, Elena R. Milaeva, Elena F. Shevtsova, Natalia A. Lozinskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5101 (2023)
Glaucoma is a widespread neurodegenerative disease for which increased intraocular pressure (IOP) is a primary modifiable risk factor. Recently, we have observed that compounds with oxindole scaffolds are involved in the regulation of intraocular pre
Externí odkaz:
https://doaj.org/article/f64c0950566d407e91abe1a380d3bdf3
Autor:
Taisiya A. Antonenko, Yulia A. Gracheva, Dmitry B. Shpakovsky, Mstislav A. Vorobyev, Dmitrii M. Mazur, Victor A. Tafeenko, Yury F. Oprunenko, Elena F. Shevtsova, Pavel N. Shevtsov, Alexey A. Nazarov, Elena R. Milaeva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2024 (2023)
A series of novel organotin(IV) complexes on the base of 2-(N-3′,5′-di-tert-butyl-4′-hydroxyphenyl)-iminomethylphenol (L) of formulae Me2SnBr2(L)2 (1), Bu2SnCl2(L)2(2), Ph2SnCl2(L) (3), Ph2SnCl2(L)2 (4) Ph3SnBr(L)2 (5) were synthesized and char
Externí odkaz:
https://doaj.org/article/1f5fd3af99954f3484a1bb71178a74c5
Autor:
Sergey O. Bachurin, Elena F. Shevtsova, Galina F. Makhaeva, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Elena V. Rudakova, Darya V. Vinogradova, Pavel N. Shevtsov, Elena A. Pushkareva, Ludmila G. Dubova, Tatiana P. Serkova, Ivan M. Veselov, Vladimir P. Fisenko, Rudy J. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13925 (2022)
The development of multi-target-directed ligands (MTDLs) would provide effective therapy of neurodegenerative diseases (ND) with complex and nonclear pathogenesis. A promising method to create such potential drugs is combining neuroactive pharmacopho
Externí odkaz:
https://doaj.org/article/bed9b9696c514d1caf241d2b10e8865d
Autor:
Maria S. Volkova, Alexander M. Efremov, Elena N. Bezsonova, Michael D. Tsymliakov, Anita I. Maksutova, Maria A. Salykina, Sergey E. Sosonyuk, Elena F. Shevtsova, Natalia A. Lozinskaya
Publikováno v:
Molecules, Vol 27, Iss 21, p 7462 (2022)
2,3-Dihydroindoles are promising agents for the synthesis of new compounds with neuroprotective and antioxidant properties. Usually, these compounds are obtained by direct reduction of the corresponding indoles containing acceptor groups in the indol
Externí odkaz:
https://doaj.org/article/8dbcec8864c348d69da9895ec2b97a5d
Autor:
Ilya A. Shutkov, Yulia N. Okulova, Vladimir Yu. Tyurin, Elena V. Sokolova, Denis A. Babkov, Alexander A. Spasov, Yulia A. Gracheva, Claudia Schmidt, Kirill I. Kirsanov, Alexander A. Shtil, Olga M. Redkozubova, Elena F. Shevtsova, Elena R. Milaeva, Ingo Ott, Alexey A. Nazarov
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13468 (2021)
A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An
Externí odkaz:
https://doaj.org/article/66d5edea20494582a053ff3482bda224
Autor:
Sergey O. Bachurin, Galina F. Makhaeva, Elena F. Shevtsova, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Pavel N. Shevtsov, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Elena A. Pushkareva, Natalia P. Boltneva, Sofya V. Lushchekina, Alexey V. Gabrelyan, Vladimir L. Zamoyski, Lyudmila G. Dubova, Elena V. Rudakova, Vladimir P. Fisenko, Elena V. Bovina, Rudy J. Richardson
Publikováno v:
Molecules, Vol 26, Iss 18, p 5527 (2021)
A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized. Conjugates act simultaneously on several biological str
Externí odkaz:
https://doaj.org/article/b4963a08afd643abb60d9c73f498c6f7