Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Elena F Koslover"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010413 (2022)
For many nuclear-encoded mitochondrial genes, mRNA localizes to the mitochondrial surface co-translationally, aided by the association of a mitochondrial targeting sequence (MTS) on the nascent peptide with the mitochondrial import complex. For a sub
Externí odkaz:
https://doaj.org/article/9e486aa56ee3495babbb461830ebe753
Autor:
Anamika Agrawal, Elena F Koslover
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009073 (2021)
Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal
Externí odkaz:
https://doaj.org/article/caff8740e8fa484cb5bbe12f3ad495a6
Autor:
Aidan I Brown, Elena F Koslover
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008654 (2021)
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to distinguish between proteins that have completed native folding, thos
Externí odkaz:
https://doaj.org/article/6a105b7d873945c5a726ace8866d4122
Autor:
Zhijie Chen, Ronen Gabizon, Aidan I Brown, Antony Lee, Aixin Song, César Díaz-Celis, Craig D Kaplan, Elena F Koslover, Tingting Yao, Carlos Bustamante
Publikováno v:
eLife, Vol 8 (2019)
Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol
Externí odkaz:
https://doaj.org/article/572da9e83d4c49dcb15a19912c6b95e2
Publikováno v:
eLife, Vol 8 (2019)
Listeria monocytogenes hijacks host actin to promote its intracellular motility and intercellular spread. While L. monocytogenes virulence hinges on cell-to-cell spread, little is known about the dynamics of bacterial spread in epithelia at a populat
Externí odkaz:
https://doaj.org/article/010c13aa085544b994b83923cc9dc0ff
Publikováno v:
eLife, Vol 7 (2018)
Eukaryotic cells modulate their metabolism by organizing metabolic components in response to varying nutrient availability and energy demands. In rat axons, mitochondria respond to glucose levels by halting active transport in high glucose regions. W
Externí odkaz:
https://doaj.org/article/fc11758b441a4f8e984fd308ec8cda08
Autor:
Fan Ye, David K Breslow, Elena F Koslover, Andrew J Spakowitz, W James Nelson, Maxence V Nachury
Publikováno v:
eLife, Vol 2 (2013)
The dynamic organization of signaling cascades inside primary cilia is key to signal propagation. Yet little is known about the dynamics of ciliary membrane proteins besides a possible role for motor-driven Intraflagellar Transport (IFT). To characte
Externí odkaz:
https://doaj.org/article/b80410ab2f0741ad817a1ee410b6b6e0
Autor:
Yunhao Sun, Zexi Yu, Christopher J. Obara, Keshav Mittal, Jennifer Lippincott-Schwartz, Elena F. Koslover
Publikováno v:
Physical Review Research, Vol 4, Iss 2, p 023182 (2022)
The analysis of single-particle trajectories plays an important role in elucidating dynamics within complex environments such as those found in living cells. However, the characterization of intracellular particle motion is often confounded by confin
Externí odkaz:
https://doaj.org/article/5e5e9f59366e49648098c7c11ae4bb0c
Publikováno v:
Molecular biology of the cell, vol 33, iss 13
Macroautophagy is a homeostatic process required to clear cellular waste. Neuronal autophagosomes form constitutively in the distal tip of the axon and are actively transported toward the soma, with cargo degradation initiated en route. Cargo turnove
Publikováno v:
Autophagy Reports. 2