Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elena Enzo"'
Autor:
Maria Pia Polito, Alessio Romaldini, Lorenzo Tagliazucchi, Grazia Marini, Federica Radice, Gaia Andrea Gozza, Giulia Bergamini, Maria Paola Costi, Elena Enzo
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this network, but the upstream signals regulating its activity remain to be elucidated. In this study,
Externí odkaz:
https://doaj.org/article/665845e23c074f57b29992a9da55e292
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Epidermal stem cells (EPSCs) are essential for maintaining skin homeostasis and ensuring a proper wound healing. During in vitro cultivations, EPSCs give rise to transient amplifying progenitors and differentiated cells, finally forming a st
Externí odkaz:
https://doaj.org/article/7be09cfcace941baa12b3bf3a0216e02
Autor:
Maria Pia Polito, Grazia Marini, Alessandra Fabrizi, Laura Sercia, Elena Enzo, Michele De Luca
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-10 (2024)
Abstract Epidermal stem cells orchestrate epidermal renewal and timely wound repair through a tight regulation of self-renewal, proliferation, and differentiation. In culture, human epidermal stem cells generate a clonal type referred to as holoclone
Externí odkaz:
https://doaj.org/article/c421b30b8308404a98973d249cce780e
Autor:
Laura Sercia, Oriana Romano, Grazia Marini, Elena Enzo, Mattia Forcato, Laura De Rosa, Michele De Luca
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101311- (2024)
Lamellar ichthyosis (LI) is a chronic disease, mostly caused by mutations in the TGM1 gene, marked by impaired skin barrier formation. No definitive therapies are available, and current treatments aim at symptomatic relief. LI mouse models often fail
Externí odkaz:
https://doaj.org/article/5964d676582b409c971425f07d256aa7
Autor:
Elena Enzo, Alessia Secone Seconetti, Mattia Forcato, Elena Tenedini, Maria Pia Polito, Irene Sala, Sonia Carulli, Roberta Contin, Clelia Peano, Enrico Tagliafico, Silvio Bicciato, Sergio Bondanza, Michele De Luca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the
Externí odkaz:
https://doaj.org/article/24ade267e8ad41b39a4b9790df32c377
Autor:
Laura De Rosa, Elena Enzo, Giulia Zardi, Christine Bodemer, Cristina Magnoni, Holm Schneider, Michele De Luca
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Epidermolysis bullosa (EB) is a group of devastating genetic diseases characterized by skin and mucosal fragility and formation of blisters, which develop either spontaneously or in response to minor mechanical trauma. There is no definitive therapy
Externí odkaz:
https://doaj.org/article/08476399f26d4f3597ce596b93c7edb9
Autor:
Laura De Rosa, Sonia Carulli, Fabienne Cocchiarella, Daniela Quaglino, Elena Enzo, Eleonora Franchini, Alberto Giannetti, Giorgio De Santis, Alessandra Recchia, Graziella Pellegrini, Michele De Luca
Publikováno v:
Stem Cell Reports, Vol 2, Iss 1, Pp 1-8 (2014)
We report a long-term follow-up (6.5 years) of a phase I/II clinical trial envisaging the use of autologous genetically modified cultured epidermal stem cells for gene therapy of junctional epidermolysis bullosa, a devastating genetic skin disease. T
Externí odkaz:
https://doaj.org/article/9282413288404e7497651bc7a7059445
Publikováno v:
International Journal of Molecular Sciences. 24:8544
The epidermis is one of the largest tissues in the human body, serving as a protective barrier. The basal layer of the epidermis, which consists of epithelial stem cells and transient amplifying progenitors, represents its proliferative compartment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c39a48f8ac0e5db8f92572698526734
https://doi.org/10.3390/ijms24108544
https://doi.org/10.3390/ijms24108544
Autor:
Shukti Chakravarti, Elena Enzo, Maithê Rocha Monteiro de Barros, Maria Benedetta Rizzarda Maffezzoni, Graziella Pellegrini
Publikováno v:
Annual review of genomics and human genetics. 23
Metazoans have evolved to produce various types of extracellular matrix (ECM) that provide structural support, cell adhesion, cell–cell communication, and regulated exposure to external cues. Epithelial cells produce and adhere to a specialized she
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78eccc29cab4d5c4e5fffefe0385cc6
https://pubmed.ncbi.nlm.nih.gov/35537467
https://pubmed.ncbi.nlm.nih.gov/35537467
Epidermolysis bullosa (EB) is a devastating genetic skin disease typified by a plethora of different phenotypes and ranking from severe, early lethal, to mild localized forms. Although there is no cure for EB, recent progress in pharmacology and mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffc2af7f9bc0d2c07cd19a37d9af8a8
https://hdl.handle.net/11380/1290764
https://hdl.handle.net/11380/1290764
