Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Elena E. Grintsevich"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16651 (2023)
Mical family enzymes are unusual actin regulators that prime filaments (F-actin) for disassembly via the site-specific oxidation of M44/M47. Filamentous actin acts as a substrate of Mical enzymes, as well as an activator of their NADPH oxidase activi
Externí odkaz:
https://doaj.org/article/10d31d93a5204f2bb5e89350b0aaef1d
Autor:
Elena E. Grintsevich, Giasuddin Ahmed, Anush A. Ginosyan, Heng Wu, Shannon K. Rich, Emil Reisler, Jonathan R. Terman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Actin-based structures in cells and tissues are built and maintained through a poorly understood balance between assembly and disassembly. Here, our findings provide insights into how factors known to promote these opposing effects dynamically integr
Externí odkaz:
https://doaj.org/article/d16f206bcaf8453d98be0d77c264773a
Autor:
Elena E. Grintsevich, Peng Ge, Michael R. Sawaya, Hunkar Gizem Yesilyurt, Jonathan R. Terman, Z. Hong Zhou, Emil Reisler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibili
Externí odkaz:
https://doaj.org/article/7ae7d1bd50ae4f3380c5ffcce5f2ab7d
Autor:
Rachel Baum, Joseph A. Palatinus, Miriam Waghalter, Daisuke Shimura, Qianru Jin, Lucas Kuzmanovich, Shaohua Xiao, André G. Kléber, Elena E. Grintsevich, TingTing Hong, Robin M. Shaw
Previously, we identified that GJA1-20k, an internally translated isoform of Connexin 43, mediates an actin-dependent protective form of mitochondrial fission (Shimura, Nuebel et al. 2021). We found that when GJA1-20k is present, bands of actin surro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b539d59a6ab492025a670d059fd8ea
https://doi.org/10.1101/2022.01.05.475034
https://doi.org/10.1101/2022.01.05.475034
Autor:
Cinzia Ambrosi, Cynthia Ren, Gaelle Spagnol, Gabriel Cavin, Angela Cone, Elena E Grintsevich, Gina E Sosinsky, Paul L Sorgen
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157073 (2016)
Gap junctions are membrane specialization domains identified in most tissue types where cells abut each other. The connexin channels found in these membrane domains are conduits for direct cell-to-cell transfer of ions and molecules. Connexin43 (Cx43
Externí odkaz:
https://doaj.org/article/c9314dfee01342acaed97132d1f09872
Autor:
Elena E. Grintsevich
Publikováno v:
Biochemical Society transactions. 49(2)
Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of dreb
Autor:
Anush A. Ginosyan, Heng Wu, Shannon K. Rich, Elena E. Grintsevich, Giasuddin Ahmed, Emil Reisler, Jonathan R. Terman
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cellular events require the spatiotemporal interplay between actin assembly and actin disassembly. Yet, how different factors promote the integration of these two opposing processes is unclear. In particular, cellular monomeric (G)-actin is complexed
Publikováno v:
Molecular biology of the cell, vol 30, iss 5
Molecular Biology of the Cell
Molecular Biology of the Cell
Dendritic spines (DS) are actin-rich postsynaptic terminals of neurons that are critical for higher-order brain functions. Maturation of DS is accompanied by a change in actin architecture from linear to branched filamentous structures. Presumably, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74d22989abc1a8325afadcc7ac97661
https://escholarship.org/uc/item/4cm3r0j7
https://escholarship.org/uc/item/4cm3r0j7
Autor:
Sanchaita Das, Zeynep A. Oztug Durer, Emil Reisler, Z. Hong Zhou, Peng Ge, Elena E. Grintsevich
Publikováno v:
Structure (London, England : 1993), vol 28, iss 5
Structure
Structure
Detailed molecular information on G-actin assembly into filaments (F-actin), and their structure, dynamics, and interactions, is essential for understanding their cellular functions. Previous studies indicate that a flexible DNase I binding loop (D-l
Autor:
Elena E, Grintsevich
Publikováno v:
Advances in experimental medicine and biology. 1006
Dendritic spines are small protrusions of dendrites that are critical for synaptic transmission. The plasticity and stability of dendritic spines is tightly linked to actin cytoskeleton. However, our understanding of specific properties and the fine-