Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elena Dzhambazova"'
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2783 (2023)
Valorphin (V1) is a naturally occurring peptide derived from hemoglobin that has been found to have an affinity for opioid receptors and exhibits antinociceptive and anticonvulsant activity. Some of its synthetic analogs containing an aminophosphonat
Externí odkaz:
https://doaj.org/article/02fcc4ca64ff441492a007c6e99c28bf
Publikováno v:
Folia Medica, Vol 63, Iss 2, Pp 189-196 (2021)
Introduction: The endogenous dipeptide L-tyrosine-L-arginine (kyotorphin, KTP) is found in brain structures related to the processing of information for nociception, the control of emotions, and memory formation. Besides the antinociceptive effect of
Externí odkaz:
https://doaj.org/article/88302919358647558825dd5cde9c3044
Publikováno v:
Science & Research (2019)
Introduction: It is well known that exposure to different stressors caused a sequence of biochemical, physiological and behavioural changes including analgesia which is realised by activating multiple endogenous pain inhibitory systems. Although the
Externí odkaz:
https://doaj.org/article/2b18b814d0e24cb0b7d4feefc25a2c2e
Autor:
Stela Georgieva, Petar Todorov, Spas Nikolov, Elena Dzhambazova, Petia Peneva, Borislav Assenov, Daniela Pechlivanova
Publikováno v:
Molecular Diversity. 27:263-280
This manuscript presented the synthesis and characterization of two new N- and C-modified analogues of VV-hemorphin-7 containing RGD (Arg-Gly-Asp) residues as potential nociceptive agents and bioactive materials. It has been shown that the addition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2a6d0e48a5b76108f3f9643bff0950
https://doi.org/10.1007/s11030-022-10428-2
https://doi.org/10.1007/s11030-022-10428-2
Publikováno v:
Protein & Peptide Letters. 28:442-449
Background: Hemorphins are endogenous hemoglobin-derived peptides that belong to the family of “atypical” opioid peptides with both affinities to opioid receptors and ability to release other endogenous opioid peptides. Objective: In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad3f56f8e3e8510d60435aa034e97d0
https://doi.org/10.2174/0929866527666200813200714
https://doi.org/10.2174/0929866527666200813200714
Publikováno v:
Folia Medica, Vol 63, Iss 2, Pp 189-196 (2021)
Introduction: The endogenous dipeptide L-tyrosine-L-arginine (kyotorphin, KTP) is found in brain structures related to the processing of information for nociception, the control of emotions, and memory formation. Besides the antinociceptive effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4215cd1c4a95056beeea566a2e9658db
https://foliamedica.bg/article/53912/
https://foliamedica.bg/article/53912/
The Neuropeptide Kyotorphin as a Possible Biomarker and Neuroprotective Agent in Alzheimer’s Disease
Publikováno v:
Journal of Biomedical and Clinical Research. 13:8-18
Summary Alzheimer’s disease (AD) is an age-related neurodegenerative disorder clinically characterized by memory impairment, disorientation, cognitive deficits, and behavioral disturbances. The neuropathological features are amyloid plaques contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40cd716ec23d9dd68e3181192ee7538
https://doi.org/10.2478/jbcr-2020-0002
https://doi.org/10.2478/jbcr-2020-0002
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3073-3079
In the present study, some new analogues of VV-hemorphin-5, modified at position 1 and 7 by the non-proteinogenic and/or natural amino acids followed the structures Xxx-Val-Val-Tyr-Pro-Trp-Thr-Gln-NH2 and Val-Val-Tyr-Pro-Trp-Thr-Yyy-NH2, where Xxx is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5e3554f46a1edba4d90c09ec93bb1d
https://doi.org/10.1016/j.bmcl.2018.07.040
https://doi.org/10.1016/j.bmcl.2018.07.040
Autor:
Hristina Angelova, Ekaterina Krumova, Elena Dzhambazova, Daniela Pechlivanova, Jeny Miteva-Staleva, Nedelina Kostadinova, Boycho Landzhov
Publikováno v:
Amino acids. 51(10-12)
The established decrease in the level of endogenous kyotorphin (KTP) into the cerebrospinal fluid of patients with an advanced stage of Alzheimer’s disease (AD) and the found neuroprotective activity of KTP suggested its participation in the pathop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1db5c776e387739ca117a7c26370f1d
https://pubmed.ncbi.nlm.nih.gov/31520285
https://pubmed.ncbi.nlm.nih.gov/31520285
