Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Elena Domínguez-Vega"'
Autor:
Isabella Senini, Sara Tengattini, Francesca Rinaldi, Gabriella Massolini, Christoph Gstöttner, Dietmar Reusch, Marcello Donini, Carla Marusic, Peter A. van Veelen, Elena Domínguez-Vega, Manfred Wuhrer, Caterina Temporini, Simone Nicolardi
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Monoclonal antibody (mAb) glycoengineering has the potential to improve the efficacy of biopharmaceuticals by fine-tuning specific biological properties. Glycosylation analysis is key to monitoring the glycoengineering process. Various mass
Externí odkaz:
https://doaj.org/article/1b14d36527f6452a9d61a7e221f66757
Autor:
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, u
Externí odkaz:
https://doaj.org/article/66693f5931e04cbdb02cb3b635c4eb80
Autor:
Christoph Gstöttner, Steffen Lippold, Michaela Hook, Feng Yang, Markus Haberger, Manfred Wuhrer, David Falck, Tilman Schlothauer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The antibody- FcγRIIIa interaction triggers key immunological responses such as antibody dependent cellular cytotoxicity (ADCC), making it highly important for therapeutic mAbs. Due to the direct glycan-glycan interaction with FcγRIIIa receptor, di
Externí odkaz:
https://doaj.org/article/17823215efd24dc59d0603caae56befe
Autor:
Christoph Gstöttner, Alexander Knaupp, Gestur Vidarsson, Dietmar Reusch, Tilman Schlothauer, Manfred Wuhrer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The impact of antibody glycoforms on FcγRIIa activation and immune responses is poorly understood. Yet, glycoform binding assessment remains one of the major analytical challenges requiring long enrichment or glycoengineering steps. Here, we develop
Externí odkaz:
https://doaj.org/article/9fdd4b98cb2049af8d3785c42cceb466
Autor:
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, David Falck
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1191-1196 (2019)
Determination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC) previously required high purity glycoengineering. We hyphenated FcɣRIIIa affinity chromatograp
Externí odkaz:
https://doaj.org/article/29cf8fc232b146ef88ded0217ad4cb13
Autor:
Thomas Sénard, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Current approaches to study glycosylation of polyclonal human immunoglobulins G (IgG) usually imply protein digestion or glycan release. While these approaches allow in-depth characterization, they also result in a loss of valuable information regard
Externí odkaz:
https://doaj.org/article/0351159d2b654d0eae826055873c3847
Autor:
Guusje van Schaick, Nadi el Hajjouti, Simone Nicolardi, Joost den Hartog, Romana Jansen, Rob van der Hoeven, Wim Bijleveld, Nicolas Abello, Manfred Wuhrer, Maurien M. A. Olsthoorn, Elena Domínguez-Vega
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1307 (2022)
Xylanases are of great value in various industries, including paper, food, and biorefinery. Due to their biotechnological production, these enzymes can contain a variety of post-translational modifications, which may have a profound effect on protein
Externí odkaz:
https://doaj.org/article/908be9aeeaa64974a1d34ec1b16749ed
Publikováno v:
Journal of Proteome Research. 22:1367-1376
Autor:
Christoph Gstöttner, Andrei Hutanu, Sacha Boon, Aurelia Raducanu, Klaus Richter, Markus Haindl, Raphael Ruppert, Elena Domínguez-Vega
Publikováno v:
Analytical Chemistry.
Autor:
Guusje van Schaick, Elena Domínguez-Vega, Jérôme Castel, Manfred Wuhrer, Oscar Hernandez-Alba, Sarah Cianférani
Publikováno v:
Analytical Chemistry, 95(8), 3932-3939. AMER CHEMICAL SOC
Post-translational modifications (PTMs) not only substantially increase structural heterogeneity of proteins but can also alter the conformation or even biological functions. Monitoring of these PTMs is particularly important for therapeutic products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cc99c0e3a33cccb97c75bf74c54b05
https://hdl.handle.net/1887/3590832
https://hdl.handle.net/1887/3590832