Výsledky vyhledávání - "Elena Dolejší"

Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling

Autor: Martin Hradilek, Iva Pichová, Pavel Majer, Filip Majer, L. Pavlíčková, Olga Hrušková-Heidingsfeldová, Elena Dolejší

Publikováno v: Biological chemistry. 387(9)

Secreted aspartic proteases (Saps) of pathogenicCandidaspp. represent a specific target for antifungal drug development. We synthesized a series of peptidomimetic inhibitors with different isosteric groups and modifications at individual positions an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ece9aff0eb9b110d5204a2e3a6ead5f
https://pubmed.ncbi.nlm.nih.gov/16972793

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Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors

Autor: Tomáš Ruml, Milan Souček, Jan Weber, Olga Hrušková-Heidingsfeldová, Iva Pichová, L. Pavlíčková, Elena Dolejší, Jiří Dostál

Publikováno v: European journal of biochemistry. 268(9)

The frequency of Candida infections has increased in recent years and it has been accompanied by a significant rise in morbidity and mortality. The secretion of aspartic proteases by Candida spp. was demonstrated to be one of the virulence determinan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d356a96ef5494ee0b989a4758f9b48
https://pubmed.ncbi.nlm.nih.gov/11322888

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